A bench, a bicycle, and a lake surrounded by trees.

Find 4 Star Hotels in Upstate South Carolina, SC from AED 481

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Check availability on Upstate South Carolina 4 Star Hotels

This weekend
3 Jul - 5 Jul
Next weekend
10 Jul - 12 Jul

Our top choices for Upstate South Carolina 4-star hotels

Exterior

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (518 reviews)
"Beautiful stay!"
United States
Shaina
The price is AED 1,062
AED 1,199 total
includes taxes & fees
6 Jul - 7 Jul
Grand Bohemian Lodge Greenville, Autograph Collection
Lobby

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (830 reviews)
"Great place to stay"
United States
Amy
The price is AED 478
AED 530 total
includes taxes & fees
6 Jul - 7 Jul
The Shepherd Hotel Downtown Clemson
Restaurant

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (756 reviews)
"The hotel is very well kept and a great place to stay for couples to get away and relax."
United States
Chris
The price is AED 687
AED 881 total
includes taxes & fees
5 Jul - 6 Jul
Hotel Hartness
Exterior

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.4 out of 10, Exceptional, (1,001 reviews)
"Beautiful stay"
United States
Christina
The price is AED 546
AED 612 total
includes taxes & fees
2 Aug - 3 Aug
The Westin Poinsett Greenville
Bar (on property)

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (672 reviews)
"The staff was excellent and the shuttle service was very accommodating. "
United States
Towana
The price is AED 434
AED 493 total
includes taxes & fees
19 Jul - 20 Jul
Greenville Marriott
Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (848 reviews)
"Great deal for the location. Apartment needed a little bit of love/attention."
Canada
Frédéric
The price is AED 437
AED 481 total
includes taxes & fees
5 Jul - 6 Jul
Mint House Greenville Downtown by Kasa
Lobby lounge

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (619 reviews)
"Great location - wonderful hotel!"
United States
Samuel
The price is AED 503
AED 558 total
includes taxes & fees
2 Aug - 3 Aug
The Abernathy of Clemson
Trailside Wedge Cottage | Terrace/patio

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (20 reviews)
"Swamp rabbit trail and restaurants very close "
United States
Martin
The price is AED 833
AED 1,219 total
includes taxes & fees
5 Jul - 6 Jul
The Station by Compo Hotels
Front of property

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (91 reviews)
"Great stay, great place and personal service."
United States
Renae
The price is AED 433
AED 664 total
includes taxes & fees
17 Jul - 18 Jul
Liberty Hall Bed and Breakfast
Lobby

Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
9.0 out of 10, Wonderful, (2 reviews)
"This is a fantastic alternative to a hotel or Air B/B. We travel for sports and ‘renting’ a fully furnished apartment is so much better. The amenities were great and the check-in process/communication was fantastic. We had a slight issue with damages and thorough cleaning, when we got there but the company took care of it ASAP."
United States
Elizabeth
Landing Apartments Greer - Sugar Creek
Studio, 1 Queen Bed (0 Bedroom) | Individually decorated, individually furnished, desk, laptop workspace

Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
4.0 star property
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
Apartment (2 Bedrooms) | Interior

Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
4.0 star property
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
Courtyard

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is AED 1,539
AED 1,693 total
includes taxes & fees
8 Jul - 9 Jul
Hotel Domestique
Apartment (2 Bedrooms) | Interior

Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
4.0 star property
Salem
Private Balcony: Lake Keowee Home w/ Pool Access
Apartment (3 Bedrooms) | Interior

Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
4.0 star property
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
Apartment (4 Bedrooms) | Interior

Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!
Apartment (2 Bedrooms) | Interior

Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
Lake Keowee Condo: Resort Pools & Lake Access!
Apartment (1 Bedroom) | Interior

Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
Apartment (3 Bedrooms) | Interior

5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
4.0 star property
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome
Apartment (2 Bedrooms) | Interior

Lake Keowee Resort Condo: Waterfront Balcony

Lake Keowee Resort Condo: Waterfront Balcony
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Very clean. Amazing amenities. Lake view that takes your breath away."
United States
Tiffany
Lake Keowee Resort Condo: Waterfront Balcony
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"Incredible hotel, probably top 3 I've ever been to. Everything was perfect."
Ashley 2-night trip
Posted 15 hours ago
The Shepherd Hotel Downtown Clemson

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Greenville Marriott is rated highly by many Expedia guests. Located in Greer, Upstate South Carolina, this 4-star hotel features lots of amenities to help make your stay comfortable and convenient.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from AED 481

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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