Find 4 Star Hotels in Upstate South Carolina, SC from AED 272

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Check availability on Upstate South Carolina 4 Star Hotels

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Compare Upstate South Carolina 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (602)
"I liked everything about The Shepherd and can’t wait to go back, it’s an amazing place to stay at!!"
The price is AED 657
AED 730 total
includes taxes & fees
3 Jul - 4 Jul
The Shepherd Hotel Downtown Clemson

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
9.6 out of 10, Exceptional, (347)
"Beautiful hotel! Art work is amazing and friendly staff! Great location "
The price is AED 889
AED 978 total
includes taxes & fees
13 Jul - 14 Jul
Grand Bohemian Lodge Greenville, Autograph Collection

The Westin Poinsett Greenville

4.0 star property
9.2 out of 10, Wonderful, (1002)
"Every person from front desk to wait staff were personable and friendly. Wonderful stay. "
The price is AED 559
AED 615 total
includes taxes & fees
29 Jun - 30 Jun
The Westin Poinsett Greenville

Mint House Greenville - Downtown

4.0 star property
9.2 out of 10, Wonderful, (669)
"Great location and walkable. Management was very responsive via text and went above and beyond to help out. "
The price is AED 354
AED 400 total
includes taxes & fees
13 Jul - 14 Jul
Mint House Greenville - Downtown

Hotel Hartness

4.0 star property
9.8 out of 10, Exceptional, (535)
"Hotel is nice and so are the people! "
The price is AED 541
AED 719 total
includes taxes & fees
6 Jul - 7 Jul
Hotel Hartness

Greenville Marriott

4.0 star property
8.6 out of 10, Excellent, (571)
"Good location with restaurant and bar. Easy and comfortable public lounging areas."
The price is AED 448
AED 509 total
includes taxes & fees
5 Jul - 6 Jul
Greenville Marriott

The Abernathy of Clemson

4.0 star property
9.6 out of 10, Exceptional, (519)
"It was a great stay!"
The price is AED 694
AED 770 total
includes taxes & fees
1 Jul - 2 Jul
The Abernathy of Clemson

Barsala At The American Spinning Mill Apartments

4.0 star property
8.0 out of 10, Very Good, (28)
"Great access to bike trail. No working elevator and 3 flights of stairs with luggage is a challenge. "
Barsala At The American Spinning Mill Apartments

Liberty Hall Bed and Breakfast

4.0 star property
10.0 out of 10, Exceptional, (65)
"In town for a recent college visit. Great location in a stunning historic BNB. Breakfast was wonderful and customer service was exceptional. Would absolutely recommend staying here and plan to stay again."
Liberty Hall Bed and Breakfast

The Station by Compo Hotels

4.0 star property
10.0 out of 10, Exceptional, (7)
"Beautiful rooms and surroundings. Less than 5 minutes from Furman university and really close to delightful and quirky travelers rest! Great place to stay!"
The price is AED 637
AED 1,003 total
includes taxes & fees
6 Jul - 7 Jul
The Station by Compo Hotels

Hotel Domestique

4.0 star property
9.6 out of 10, Exceptional, (29)
"This place is a hidden gem. It is beautiful in every way. The staff is wonderful. The restaurant was incredible. Can’t wait to go back for a longer stay."
The price is AED 1,575
AED 1,733 total
includes taxes & fees
24 Jun - 25 Jun
Hotel Domestique

Southern Sunshine Retreat

4.0 star property
Southern Sunshine Retreat

Lake Hartwell Frank Howard Home Clemson

4.0 star property
The price is AED 272
AED 1,465 total
includes taxes & fees
24 Jun - 25 Jun
Lake Hartwell Frank Howard Home Clemson

Belvedere

4.0 star property
8.0 out of 10, Very Good, (1)
"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? "
Belvedere

228 Lakeland

4.0 star property
228 Lakeland

140 Catlin Circle

4.0 star property
140 Catlin Circle

Randall St , 202/204

4.0 star property
Randall St , 202/204

34 Allen St

4.0 star property
34 Allen St
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Greenville Marriott is rated highly by many Expedia guests. Located in Greer, Upstate South Carolina, this 4-star hotel features lots of amenities to help make your stay comfortable and convenient.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from AED 272

What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax --- think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.