Are there any 5-star all-inclusive resorts in Panama City?

Our filter tool is the quickest way to narrow down what you're looking for. Check the "All inclusive" and "5-star" boxes to show the most luxurious hotels in Panama City where your room, meals, activities and entertainment are included in the upfront price. At these stays, your vacation is pure indulgence from the moment you put down your suitcase.

What are the top 5-star spa hotels in Panama City?

Recharge your batteries with a decadent massage and other rejuvenating treatments at Waldorf Astoria Panama . It's one of Panama City's most popular 5-star spa escapes. W Panama and Bristol Panama, a Registry Collection Hotel also blend upmarket accommodations with a range of wellness therapies.

Are there any 5-star vacation rentals in Panama City?

There are no 5-star vacation rentals in Panama City on our site, but there are a range of other highly rated properties worth looking into. Scan through our vacation rentals in Panama City to book the perfect place for your getaway.

Are there any 5-star hotels in downtown Panama City?

Base yourself at Bristol Panama, a Registry Collection Hotel and take advantage of being near the sights and sounds of downtown Panama City.

What are the top 5-star hotels near Marcos A. Gelabert Intl. Airport (PAC)?

Take the stress out of early or late flights and book Villa Palma Boutique Hotel for your next visit to Panama City. Conveniently located 6 kilometers southeast of Marcos A. Gelabert Intl. Airport (PAC), you'll look forward to having extra time in your schedule to indulge in the quality perks this 5-star escape has to offer.

The Best 5 Star Hotels in Panama City from AED 513

A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Panama City 5 Star Hotels

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Panama City 5-star hotels

Hotel Riu Plaza Panama

Bella Vista

Yohan

AED 562 total

includes taxes & fees

30 Jun - 1 Jul

Waldorf Astoria Panama

Bella Vista

Fernando

AED 1,149 total

includes taxes & fees

3 Jul - 4 Jul

W Panama

Bella Vista

Ruth P

AED 1,006 total

includes taxes & fees

3 Jul - 4 Jul

Room, 1 King Bed, Balcony, Oceanfront (Magnifique) | Premium bedding, down comforters, pillowtop beds, minibar

Sofitel Legend Casco Viejo, Panama City

Casco Viejo

Vesna

AED 1,218 total

includes taxes & fees

12 Jul - 13 Jul

4 outdoor pools, free cabanas, pool umbrellas

JW Marriott Panama

San Francisco

Robert

AED 1,096 total

includes taxes & fees

26 Jul - 27 Jul

Hyatt Regency Panama City

Bella Vista

Craig

AED 853 total

includes taxes & fees

4 Jul - 5 Jul

40-inch Smart TV with cable channels, TV

Renaissance Panama City Hotel

Bella Vista

AED 513 total

includes taxes & fees

3 Jul - 4 Jul

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

Marina

AED 1,051 total

includes taxes & fees

9 Jul - 10 Jul

3 outdoor pools, pool umbrellas, sun loungers

The Westin Playa Bonita Panama

Veracruz

Shernon

AED 833 total

includes taxes & fees

8 Jul - 9 Jul

Hilton Panama

Bella Vista

Ashley

AED 999 total

includes taxes & fees

26 Jul - 27 Jul

Couples treatment rooms, sauna, steam room, body treatments

Bristol Panama, a Registry Collection Hotel

Bella Vista

Rafael

AED 899 total

includes taxes & fees

17 Jul - 18 Jul

Megapolis Hotel Panamá

San Francisco

MARVIN

Waymore Hotel Spa and Casino

Bella Vista

Aldo

Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

AED 466

AED 537 total

20 Jul - 21 Jul

includes taxes & fees

8.6/10 Excellent! (2,602 reviews)

Still don't see what you're looking for?

See all properties in Panama City.

You can also use these popular filters to refine your search.

Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City

A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.