A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

Find 5 Star Hotels in Panama City from AED 425

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Check availability on Panama City 5 Star Hotels

Tonight
2 Oct - 3 Oct
Tomorrow
3 Oct - 4 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Panama City 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.
A modern hotel room with a dining area, a TV, and a city view.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Sandrelly
AED 506
AED 556 total
includes taxes & fees
25 Oct - 26 Oct
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A modern building with a rooftop lounge area, large windows, and a balcony overlooking a cityscape.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
AED 931
AED 1,024 total
includes taxes & fees
31 Oct - 1 Nov
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
AED 1,471
AED 1,618 total
includes taxes & fees
5 Oct - 6 Oct
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
AED 466
AED 513 total
includes taxes & fees
9 Oct - 10 Oct
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.
A terrace with seating and a view of the ocean.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Nemanja
AED 937
AED 1,031 total
includes taxes & fees
17 Oct - 18 Oct
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A spacious hotel lobby with modern furniture, large windows, and a city view.
A modern building with a sign reading 'HYATT REGENCY.'
A spacious lobby with a curved ceiling, a central staircase, and a reception desk.

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Mariah
AED 687
AED 756 total
includes taxes & fees
11 Oct - 12 Oct
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.
A pool with a central water feature, surrounded by seating areas and potted plants.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Shelly-Ann
AED 879
AED 967 total
includes taxes & fees
9 Oct - 10 Oct
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A high-rise building with a rooftop pool area, surrounded by other buildings.

8. W Panama

W Panama
Bella Vista
United States
Naomi
AED 849
AED 934 total
includes taxes & fees
1 Nov - 2 Nov
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.
A modern bar area with seating and a view of the city.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Simon
AED 913
AED 1,004 total
includes taxes & fees
10 Oct - 11 Oct
Hilton Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.
A beachfront hotel with a large building, a beach, and a clear sky.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Anna
AED 757
AED 833 total
includes taxes & fees
12 Oct - 13 Oct
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A cozy outdoor seating area with a wooden bench and white tables, surrounded by lush greenery and potted plants.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
AED 777
AED 855 total
includes taxes & fees
3 Oct - 4 Oct
Bristol Panama, a Registry Collection Hotel
Lobby
Outdoor pool
Breakfast area
Bar (on property)

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
AED 385
AED 425 total
includes taxes & fees
4 Oct - 5 Oct
Waymore Hotel Spa and Casino
Terrace/patio
Outdoor pool
Room
Outdoor spa tub

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
AED 785
AED 867 total
includes taxes & fees
24 Oct - 25 Oct
Megapolis Hotel Panamá
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
AED 492
AED 566 total
30 Oct - 31 Oct
includes taxes & fees
8.6/10 Excellent! (2,757 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
AED 699
AED 768 total
5 Oct - 6 Oct
includes taxes & fees
9/10 Wonderful! (1,002 reviews)
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
AED 531
AED 584 total
26 Oct - 27 Oct
includes taxes & fees
8.6/10 Excellent! (1,772 reviews)
Megapolis Hotel Panamá
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.

Top Panama City Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Lovely property, an extensive breakfast buffet. Centrally located. Affordable parking/valet service. Great customer service. We also got a crib at no charge for our baby."
Kavita 4-night trip
Posted 7 hours ago
Hotel Riu Plaza Panama

Frequently asked questions

What are the best 5-star hotels in Panama City?
Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are some of the top 5-star hotels in Panama City, based on reviews by our customers. These swanky hotels rate highly for things like their location, amenities and guest service standards. Pick your favorite and enjoy the best of it all.
How much does it cost to stay in a 5-star hotel in Panama City?
The amount you pay for a 5-star hotel in Panama City depends on factors such as when you plan to travel and the length of your escape. An insider tip for landing an awesome deal? Use our pricing filters to check out all of the available hotels for your preferred dates.
  • Search for the lowest price per night from AED 566
What makes a hotel 5 stars in Panama City?
In Panama City, a hotel needs to provide a specific amount of upscale conveniences to earn a 5-star rating. These can include on-site gyms, saunas and spas, gourmet restaurants, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their guest-focused service. You'll enjoy things like nightly turn-down services, concierge services and in-room massages. Some may even offer thoughtful touches like welcome gifts.