Find 5 Star Hotels in San Francisco from AED 444

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Check availability on San Francisco 5 Star Hotels

Tonight
7 Dec - 8 Dec
Tomorrow
8 Dec - 9 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Compare San Francisco 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4627)
"Awesome great place to stay "
United States
Herbert
The price is AED 450
AED 495 total
includes taxes & fees
8 Dec - 9 Dec
Hotel Riu Plaza Panama
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1001)
"I loved everything about my stay "
United States
Stephanie
The price is AED 660
AED 726 total
includes taxes & fees
17 Dec - 18 Dec
Waldorf Astoria Panama
2 restaurants, local cuisine
W Panama

W Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1003)
"Clean room, great views, great staff!"
United States
Ashley
The price is AED 761
AED 837 total
includes taxes & fees
16 Dec - 17 Dec
W Panama
4 outdoor pools, free cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1005)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is AED 922
AED 1,014 total
includes taxes & fees
4 Jan - 5 January 2026
JW Marriott Panama
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (553)
"Great hotel and location "
United Kingdom
Russell
The price is AED 1,504
AED 1,654 total
includes taxes & fees
15 Dec - 16 Dec
Sofitel Legend Casco Viejo, Panama City
Outdoor pool
Hilton Panama

Hilton Panama

5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"Great place to stay."
United States
Salvador
The price is AED 684
AED 752 total
includes taxes & fees
2 Jan - 3 January 2026
Hilton Panama
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very Good, (1003)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is AED 643
AED 708 total
includes taxes & fees
17 Dec - 18 Dec
The Westin Playa Bonita Panama
40-inch Smart TV with cable channels, TV
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5.0 star property
Bella Vista
8.8 out of 10, Excellent, (93)
"Great location and amazing staff"
United States
Aziz
The price is AED 426
AED 469 total
includes taxes & fees
13 Dec - 14 Dec
Renaissance Panama City Hotel
Couples treatment rooms, sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is AED 674
AED 742 total
includes taxes & fees
12 Dec - 13 Dec
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is AED 851
AED 936 total
includes taxes & fees
12 Dec - 13 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
View from property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

5.0 star property
San Francisco
8.4 out of 10, Very Good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá
Outdoor pool
Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino

5.0 star property
Bella Vista
6.2 out of 10, (1000)
"It has a nice casino and it's very conveniently located. Breakfast was very good as well. Staff very helpful and attention oriented. Good experience "
United States
Aldo
Waymore Hotel Spa and Casino
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in San Francisco.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
The price is AED 404 per night from Dec 23 to Dec 24
AED 404
AED 444 total
23 Dec - 24 Dec
includes taxes & fees
8.4/10 Very Good! (2,320 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top San Francisco Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Very good breakfast and very nice hotel and close to lots of restaurants "
Michele 4-night trip
Posted 1 day ago
Hotel Riu Plaza Panama

Frequently asked questions

What are the best 5-star hotels in San Francisco?
JW Marriott Panama is among the most popular picks around the Panama City neighborhood of San Francisco based on Expedia customer reviews. The Bahia Grand Hotel and Bristol Panama, a Registry Collection Hotel are other 5-star hotels in this area that rank highest with guests.
How much does it cost to stay in a 5-star hotel in San Francisco?
There are a variety of pricing options for 5-star hotels in San Francisco on Expedia. How much you'll pay will depend on when you travel, length of stay and other factors. Compare all of the available accommodations for your chosen dates and use our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from AED 444

What makes a hotel 5 stars in San Francisco?
Faultless guest service is the foundation of every 5-star hotel in San Francisco. From the minute you step through the door, staff ensure your every need is met, whether recommending activities or providing in-room massage treatments. Additionally, hotels have to feature upscale amenities to be considered for a 5-star rating. These can include luxury toiletries, saunas or spas, pools, gourmet kitchens and knowledgeable concierge.

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