Find 5 Star Hotels in Santee, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee 5 Star Hotels

Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santee.
Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion

401 Bass Drive Santee SC
Get rates
9.2/10 Wonderful! (21 reviews)
Still don't see what you're looking for?
See all properties in Santee.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Santee?
How much you pay for a 5-star hotel in Santee can vary depending on what time of year you travel and how long you plan to stay, among a range of factors. Take advantage of our price per night filter and other search tools to find the best rate on a high-end stay.

  • Search for the lowest price per night

What makes a hotel 5 stars in Santee?
From fine dining restaurants and 24-hour gyms to swimming pools and luxury bedding, the 5-star experience in Santee is all about indulgence and comfort. But it requires more than just top-notch perks to earn a 5-star rating. Accommodations also have to offer remarkable guest-focused services like in-room beauty treatments, on-site laundry and dry cleaning and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Santee?
Find an indulgent getaway that includes your room, meals, activities and entertainment in Santee with our filters. Search for properties with a 5-star rating and select the "All inclusive" filter. Be sure to check what's included in the purchase price. That way, you're ready to take advantage of the premium perks on offer as soon as you arrive.

Explore a world of travel with Expedia