An aerial view of a historic city center with terracotta-roofed buildings, a prominent red-brick structure, and modern high-rises in the background.

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This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for San Antonio hotels

An outdoor patio with a glass table and chairs, surrounded by lush greenery and illuminated by green lighting.

1. Alko Hotel Casa Nispero

Alko Hotel Casa Nispero
4.0 star property
San Antonio
9.4 out of 10, Exceptional, (249 reviews)
"Excellent. Location, location, location...the best"
United States
ALVARO
The price is AED 386
AED 386 total
19 Oct - 20 Oct
Alko Hotel Casa Nispero
A lobby with a fountain, indoor plants, a dining area, and a painting of a house on the wall.

2. San Antonio Hotel Boutique

San Antonio Hotel Boutique
3.0 star property
San Antonio
9.2 out of 10, Wonderful, (69 reviews)
"The location was excellent, within close distance to many good restaurants. The breakfast was good, with fruit and made to order eggs. The AC was quite adequate. "
United States
Jung
The price is AED 246
AED 315 total
4 Nov - 5 Nov
San Antonio Hotel Boutique
A modern living room with a sofa, a coffee table, and decorative items.

3. Hotel habitat san antonio

Hotel habitat san antonio
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Personal muy servicial y atenta"
Colombia
Giovanny
The price is AED 184
AED 184 total
16 Oct - 17 Oct
Hotel habitat san antonio
An indoor dining area with tables and chairs, surrounded by hanging plants and greenery.

4. Viajero Cali Hostel & Salsa School

Viajero Cali Hostel & Salsa School
2.0 star property
San Antonio
9.0 out of 10, Wonderful, (69 reviews)
"Excellent stay. I stayed in a private room which was small, basic but comfortable. The staff were friendly. The hostel is in a excellent location close to restaurants, bars and attractions. The extra activities and the salsa school were amazing."
Australia
Jasmine
The price is AED 223
AED 223 total
26 Oct - 27 Oct
Viajero Cali Hostel & Salsa School
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.

5. Hotel Casa Bresse

Hotel Casa Bresse
2.5 star property
San Antonio
9.2 out of 10, Wonderful, (5 reviews)
"I am frequent in this hotel , pure colonial beauty with an inside court. Clean , spacious rooms, hot water . Staff friendly and helpful , hotel is close to everything Cali has to offer. Love it."
Canada
Stanislaw
The price is AED 168
AED 168 total
15 Nov - 16 Nov
Hotel Casa Bresse
A modern kitchen with a central island, two wicker bar stools, a red pendant light, and a large window with a view.

6. Epifania Guest House

Epifania Guest House
1.0 star property
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Me gustó todo, muy bien ambiente, excelente trato, muy limpio....."
Mexico
David Alejandro
The price is AED 77
AED 77 total
22 Oct - 23 Oct
Epifania Guest House
A hallway with a large potted plant, a wooden bench, and a chandelier.

7. Casa feliz

Casa feliz
1.0 star property
San Antonio
The price is AED 56
AED 56 total
1 Nov - 2 Nov
Casa feliz
A stone fountain with a child statue, surrounded by potted plants and a tiled wall with a window and a framed picture.

8. casa hostal ave maria san antonio cali

casa hostal ave maria san antonio cali
2.0 star property
San Antonio
4.0 out of 10, (2 reviews)
"Cheap and convenient location. But mosquitoes in room every night and leaky toilet. There are better options available. "
Australia
Meyer
The price is AED 54
AED 54 total
16 Oct - 17 Oct
casa hostal ave maria san antonio cali
A hotel with a modern facade, a prominent sign, and a landscaped entrance area.

9. InterContinental Cali by IHG

InterContinental Cali by IHG
4.0 star property
El Peñon, 0.3 km from San Antonio
9.0 out of 10, Wonderful, (1,000 reviews)
"Very good hotel and staff"
United States
Pedro
The price is AED 496
AED 496 total
14 Nov - 15 Nov
InterContinental Cali by IHG
A swimming pool with a tiled deck, a dining area with chairs and a table, and a wall decorated with posters.

10. hotel boutique casa vecchia

hotel boutique casa vecchia
3.0 star property
0.4 km from San Antonio
10.0 out of 10, Exceptional, (1 review)
"Todo super bien, buena ubicación"
Colombia
carolina
The price is AED 155
AED 155 total
15 Nov - 16 Nov
hotel boutique casa vecchia
A hotel lobby with a grand chandelier, seating area, and a decorative plant centerpiece.

11. Hotel Dann Carlton Cali

Hotel Dann Carlton Cali
3.5 star property
El Peñon, 0.4 km from San Antonio
8.8 out of 10, Excellent, (485 reviews)
"the best place to stay in Cali"
United States
Sarah
The price is AED 346
AED 346 total
8 Nov - 9 Nov
Hotel Dann Carlton Cali
A restaurant with outdoor seating, a brick wall, and hanging lights.

12. Hotel el Peñón By Bithotels

Hotel el Peñón By Bithotels
4.0 star property
El Peñon, 0.4 km from San Antonio
9.0 out of 10, Wonderful, (480 reviews)
"Great hotel, centrally located"
Australia
ross
The price is AED 221
AED 221 total
14 Nov - 15 Nov
Hotel el Peñón By Bithotels
A modern hotel with a flat facade, balconies with plants, and a visible entrance.

13. Hotel Foresto 365

Hotel Foresto 365
4.0 star property
El Peñon, 0.5 km from San Antonio
9.6 out of 10, Exceptional, (71 reviews)
"Staff was super friendly."
United Kingdom
Axel
The price is AED 206
AED 206 total
17 Oct - 18 Oct
Hotel Foresto 365
A bedroom with a bed, two bedside lamps, a coffee maker, a framed painting, and a potted plant.

14. Hotel Casa Murano JLS

Hotel Casa Murano JLS
2.0 star property
0.5 km from San Antonio
The price is AED 129
AED 129 total
17 Oct - 18 Oct
Hotel Casa Murano JLS
A dining area with wooden chairs and tables, a central plant, and wall-mounted lights.

15. NH Boulevard Del Río Cali

NH Boulevard Del Río Cali
3.5 star property
Centenario, 0.7 km from San Antonio
9.0 out of 10, Wonderful, (385 reviews)
"Constable bed, dark and quiet room, the staff was very nice and always willing to help."
United States
Regis
The price is AED 264
AED 264 total
18 Oct - 19 Oct
NH Boulevard Del Río Cali
A rooftop pool with a tiled edge, a sign indicating a Jacuzzi, and a view of a cityscape with buildings and hills in the background.

16. Faranda Collection Cali, a member of Radisson Individuals

Faranda Collection Cali, a member of Radisson Individuals
4.0 star property
0.6 km from San Antonio
9.0 out of 10, Wonderful, (160 reviews)
"Great hotel and staff. Perfect location"
United States
Nicholas
The price is AED 274
AED 274 total
7 Nov - 8 Nov
Faranda Collection Cali, a member of Radisson Individuals
A historic building with a central courtyard, stone steps, and a traditional balcony.

17. Hotel Stein Colonial

Hotel Stein Colonial
3.0 star property
Juanambú, 0.6 km from San Antonio
9.4 out of 10, Exceptional, (274 reviews)
"Super friendly staff, beautiful historic hotel, & great location/breakfast!"
United States
kevin
The price is AED 201
AED 201 total
8 Nov - 9 Nov
Hotel Stein Colonial
A spacious lobby with a beige sofa, a chandelier, and a reception desk.

18. Hotel Obelisco

Hotel Obelisco
4.0 star property
El Peñon, 0.7 km from San Antonio
8.8 out of 10, Excellent, (554 reviews)
"Amazing place to stay! Staff are super friendly, breakfast is amazing especially the empanadas! Room always clean. We always enjoy our stay here"
Canada
Gabriela
The price is AED 302
AED 302 total
3 Nov - 4 Nov
Hotel Obelisco
A hotel room with two beds, a TV, a desk, and a bathroom.

19. Hotel Centro

Hotel Centro
2.0 star property
0.8 km from San Antonio
The price is AED 143
AED 143 total
16 Oct - 17 Oct
Hotel Centro
A modern indoor space with hanging wicker lamps, large windows, and indoor plants.

20. Now Hotel Cali - Adults Only

Now Hotel Cali - Adults Only
4.0 star property
Juanambú, 1.1 km from San Antonio
8.8 out of 10, Excellent, (503 reviews)
"Very nice boutique hotel. Staff extremely friendly."
United States
Osvaldo
The price is AED 265
AED 265 total
15 Nov - 16 Nov
Now Hotel Cali - Adults Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in San Antonio

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
An outdoor patio with a glass table and chairs, surrounded by lush greenery and illuminated by green lighting.
Alko Hotel Casa Nispero
4.0 star property
9.4
Exceptional
249 reviews
View
A lobby with a fountain, indoor plants, a dining area, and a painting of a house on the wall.
San Antonio Hotel Boutique
3.0 star property
9.2
Wonderful
69 reviews
View
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.
Hotel Casa Bresse
2.5 star property
9.2
Wonderful
5 reviews
View
An indoor dining area with tables and chairs, surrounded by hanging plants and greenery.
Viajero Cali Hostel & Salsa School
2.0 star property
9.0
Wonderful
69 reviews
View
A modern kitchen with a central island, two wicker bar stools, a red pendant light, and a large window with a view.
Epifania Guest House
1.0 star property
10.0
Exceptional
1 review
View

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most.
A cityscape with dense urban buildings, a prominent hill, and a distant mountain range under a cloudy sky.

Ciudad Jardín

Unique features of Ciudad Jardín include the restaurants and shopping. Make a stop by Palmas Mall or Las Velas Shopping Center while you're exploring the area.

A yellow monument with a bell, surrounded by trees and a fence.

Granada

Visitors to Granada enjoy its shopping, and if you want to do some exploring, Lugar a Dudas is worth a stop.

An aerial view of a city with dense high-rise buildings, a roundabout, and surrounding greenery.

El Peñon

When in El Peñon, you can plan a visit to Gato de Tejada Monument and Calima Gold Museum of the Bank of the Republic, some noteworthy sights in the nearby area.

Pance

Pance might not have many top sights, but Chorrera del Indio and Los Arrayanes Recreational Center are two attractions nearby that you can check out.

Top San Antonio Hotel Reviews

MS Pacífico Chipichape Plus

MS Pacífico Chipichape Plus

10/10 Excellent
"We had a great stay at this hotel while traveling with our family. We booked two rooms, and everything was clean and comfortable. The staff was very friendly and always willing to help. Breakfast was included and was good, although a little more variety would have been nice. The location was excellent! We were within walking distance of chipichape, exito, restaurants, pharmacies, small grocery stores., which made everything more convenient. Overall we really enjoyed our stay and would definitely recommend this hotel to other families visiting the area. We would happily stay here again!"
Luis Gabriel Valderrama 8-night trip
Posted 2 days ago
MS Pacífico Chipichape Plus

Frequently asked questions

What's it like in San Antonio?
Travelers to the San Antonio neighborhood in Cali will be sure to enjoy their stay.
What's a favorite place to stay in San Antonio?
Based on our traveler data, Alko Hotel Casa Nispero is one of the top choices for your stay in San Antonio. This hotel offers free breakfast and a restaurant. Another good option for your stay in the area is Viajero Cali Hostel & Salsa School.
How many hotels should I expect to find in the San Antonio area?
If you're searching for places to stay in Cali, Expedia has something to meet your needs with 52 San Antonio hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in San Antonio, will I receive a refund?
Yes, most room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available in San Antonio.
Where can I learn more about changing or cancelling my trip to San Antonio?
For additional details about updating your trip to San Antonio or cancelling it, head over to our customer service page.
What can I see and do in this Cali neighborhood?
Centro Cultural de Cali, Religious Art Museum, and Enrique Buenaventura Municipal Theater are just a few of the places to visit in and around San Antonio. While you're out sightseeing, La Merced Archaeological Museum and Calima Gold Museum of the Bank of the Republic are a couple of additional sights to visit in Cali.