An aerial view of a historic city center with terracotta-roofed buildings, a prominent red-brick structure, and modern high-rises in the background.

Find hotels in San Antonio, Cali

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for San Antonio hotels

A spiral staircase in a courtyard surrounded by lush greenery and concrete structures.

1. Alko Hotel Casa Nispero

Alko Hotel Casa Nispero
4.0 star property
San Antonio
9.4 out of 10, Exceptional, (250 reviews)
"Excellent. Location, location, location...the best"
United States
ALVARO
The price is AED 558
AED 558 total
28 Oct - 29 Oct
Alko Hotel Casa Nispero
A lobby with a fountain, indoor plants, a dining area, and a painting of a house on the wall.

2. San Antonio Hotel Boutique

San Antonio Hotel Boutique
3.0 star property
San Antonio
9.2 out of 10, Wonderful, (69 reviews)
"The location was excellent, within close distance to many good restaurants. The breakfast was good, with fruit and made to order eggs. The AC was quite adequate. "
United States
Jung
The price is AED 257
AED 327 total
4 Nov - 5 Nov
San Antonio Hotel Boutique
A modern living room with a sofa, a coffee table, and decorative items.

3. Hotel habitat san antonio

Hotel habitat san antonio
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Personal muy servicial y atenta"
Colombia
Giovanny
The price is AED 185
AED 185 total
4 Nov - 5 Nov
Hotel habitat san antonio
Pool

4. Viajero Cali Hostel & Salsa School

Viajero Cali Hostel & Salsa School
2.0 star property
San Antonio
9.0 out of 10, Wonderful, (70 reviews)
"Excellent stay. I stayed in a private room which was small, basic but comfortable. The staff were friendly. The hostel is in a excellent location close to restaurants, bars and attractions. The extra activities and the salsa school were amazing."
Australia
Jasmine
The price is AED 188
AED 188 total
26 Oct - 27 Oct
Viajero Cali Hostel & Salsa School
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.

5. Hotel Casa Bresse

Hotel Casa Bresse
2.5 star property
San Antonio
9.2 out of 10, Wonderful, (5 reviews)
"I am frequent in this hotel , pure colonial beauty with an inside court. Clean , spacious rooms, hot water . Staff friendly and helpful , hotel is close to everything Cali has to offer. Love it."
Canada
Stanislaw
The price is AED 154
AED 154 total
27 Oct - 28 Oct
Hotel Casa Bresse
A bedroom with a bed, a nightstand, a wall clock, and a door leading to a balcony.

6. Our Home San Antonio

Our Home San Antonio
2.5 star property
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Super friendly staff. Good food. Great frozen coffee. Nice location, closed to major city attractions."
United States
gloria
The price is AED 113
AED 170 total
17 Nov - 18 Nov
Our Home San Antonio
A modern kitchen with a central island, two wicker bar stools, a red pendant light, and a large window with a view.

7. Epifania Guest House

Epifania Guest House
1.0 star property
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Me gustó todo, muy bien ambiente, excelente trato, muy limpio....."
Mexico
David Alejandro
The price is AED 77
AED 77 total
14 Nov - 15 Nov
Epifania Guest House
A bathroom with a white sink, a toilet, and a shower stall with shelves for toiletries.

8. casa hostal ave maria san antonio cali

casa hostal ave maria san antonio cali
2.0 star property
San Antonio
4.0 out of 10, (2 reviews)
"Cheap and convenient location. But mosquitoes in room every night and leaky toilet. There are better options available. "
Australia
Meyer
The price is AED 54
AED 54 total
25 Oct - 26 Oct
casa hostal ave maria san antonio cali
A hotel with a modern facade, a prominent sign, and a landscaped entrance area.

9. InterContinental Cali by IHG

InterContinental Cali by IHG
4.0 star property
El Peñon, 0.3 km from San Antonio
9.0 out of 10, Wonderful, (1,000 reviews)
"Very good hotel and staff"
United States
Pedro
The price is AED 496
AED 496 total
22 Nov - 23 Nov
InterContinental Cali by IHG
A hotel lobby with a grand chandelier, seating area, and a decorative plant centerpiece.

10. Hotel Dann Carlton Cali

Hotel Dann Carlton Cali
3.5 star property
El Peñon, 0.4 km from San Antonio
8.8 out of 10, Excellent, (488 reviews)
"the best place to stay in Cali"
United States
Sarah
The price is AED 369
AED 369 total
14 Nov - 15 Nov
Hotel Dann Carlton Cali
A modern living room with a hammock, a large potted plant, a sofa, and a coffee table.

11. Hotel el Peñón By Bithotels

Hotel el Peñón By Bithotels
4.0 star property
El Peñon, 0.4 km from San Antonio
9.0 out of 10, Wonderful, (482 reviews)
"Great hotel, centrally located"
Australia
ross
The price is AED 216
AED 216 total
23 Nov - 24 Nov
Hotel el Peñón By Bithotels
A rooftop pool with a tiled edge, a sign indicating a Jacuzzi, and a view of a cityscape with buildings and hills in the background.

12. Faranda Collection Cali, a member of Radisson Individuals

Faranda Collection Cali, a member of Radisson Individuals
4.0 star property
La Merced, 0.6 km from San Antonio
9.0 out of 10, Wonderful, (160 reviews)
"Great hotel and staff. Perfect location"
United States
Nicholas
The price is AED 301
AED 301 total
29 Oct - 30 Oct
Faranda Collection Cali, a member of Radisson Individuals
A swimming pool with a tiled deck, a dining area with chairs and a table, and a wall decorated with posters.

13. hotel boutique casa vecchia

hotel boutique casa vecchia
3.0 star property
San Cayetano, 0.4 km from San Antonio
10.0 out of 10, Exceptional, (1 review)
"Todo super bien, buena ubicación"
Colombia
carolina
The price is AED 157
AED 157 total
25 Oct - 26 Oct
hotel boutique casa vecchia
A hotel with a modern facade, outdoor seating area, and vertical gardens.

14. Hotel Foresto 365

Hotel Foresto 365
4.0 star property
El Peñon, 0.5 km from San Antonio
9.6 out of 10, Exceptional, (71 reviews)
"Staff was super friendly."
United Kingdom
Axel
The price is AED 221
AED 221 total
24 Oct - 25 Oct
Hotel Foresto 365
A bedroom with a bed, two bedside lamps, a coffee maker, a framed painting, and a potted plant.

15. Hotel Casa Murano JLS

Hotel Casa Murano JLS
2.0 star property
La Merced, 0.5 km from San Antonio
The price is AED 164
AED 164 total
24 Oct - 25 Oct
Hotel Casa Murano JLS
A hotel room with two beds, a TV, a desk, and a bathroom.

16. Hotel Centro

Hotel Centro
2.0 star property
0.8 km from San Antonio
The price is AED 142
AED 142 total
3 Nov - 4 Nov
Hotel Centro
A historic building with a central courtyard, stone steps, and a traditional balcony.

17. Hotel Stein Colonial

Hotel Stein Colonial
3.0 star property
Juanambú, 0.6 km from San Antonio
9.4 out of 10, Exceptional, (275 reviews)
"Super friendly staff, beautiful historic hotel, & great location/breakfast!"
United States
kevin
The price is AED 201
AED 201 total
8 Nov - 9 Nov
Hotel Stein Colonial
A hotel room with a bed, bedside tables, a desk, a trash bin, and a framed picture on the wall.

18. Hotel Obelisco

Hotel Obelisco
4.0 star property
El Peñon, 0.7 km from San Antonio
8.8 out of 10, Excellent, (556 reviews)
"Great customer service, very clean and good food"
United States
James
The price is AED 265
AED 265 total
23 Nov - 24 Nov
Hotel Obelisco
A dining area with wooden chairs and tables, a central plant, and wall-mounted lights.

19. NH Boulevard Del Río Cali

NH Boulevard Del Río Cali
3.5 star property
Centenario, 0.7 km from San Antonio
9.0 out of 10, Wonderful, (388 reviews)
"Constable bed, dark and quiet room, the staff was very nice and always willing to help."
United States
Regis
The price is AED 340
AED 340 total
22 Nov - 23 Nov
NH Boulevard Del Río Cali
A hotel lobby with a grand chandelier, seating area, and a decorative plant centerpiece.

20. Hotel Dann Cali

Hotel Dann Cali
3.0 star property
El Peñon, 0.4 km from San Antonio
8.6 out of 10, Excellent, (618 reviews)
"Nice hotel, nice buffet, excellent location and friendly staff, definitely I'll come back"
United States
Holmes
The price is AED 288
AED 288 total
8 Nov - 9 Nov
Hotel Dann Cali
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most.
A cityscape with dense urban buildings, a prominent hill, and a distant mountain range under a cloudy sky.

Ciudad Jardín

Unique features of Ciudad Jardín include the restaurants and shopping. Make a stop by Palmas Mall or Las Velas Shopping Center while you're exploring the area.

A yellow monument with a bell, surrounded by trees and a fence.

Granada

Visitors to Granada enjoy its shopping, and if you want to do some exploring, Lugar a Dudas is worth a stop.

An aerial view of a city with dense high-rise buildings, a roundabout, and surrounding greenery.

El Peñon

When in El Peñon, you can plan a visit to Gato de Tejada Monument and Calima Gold Museum of the Bank of the Republic, some noteworthy sights in the nearby area.

Pance

Pance might not have many top sights, but Chorrera del Indio and Los Arrayanes Recreational Center are two attractions nearby that you can check out.

Top San Antonio Hotel Reviews

Now Hotel Cali - Adults Only

Now Hotel Cali - Adults Only

10/10 Excellent
"Now Hotel Cali, un lugar con un personal que realmente se preocupa por sus huéspedes! Mi estadía en Now Hotel Cali fue maravillosa de principio a fin. Es un hotel boutique moderno y acogedor, con habitaciones impecables y muy cómodas. La ubicación es excelente: muy cerca de Granada, así que fue facilísimo salir a comer y disfrutar de la ciudad. Todo el personal nos recibió con mucha calidez y nos hizo sentir como en casa desde el primer momento. Pero quiero hacer un agradecimiento muy especial a Félix, quien literalmente nos salvó el día. Ya íbamos camino al aeropuerto cuando nos dimos cuenta de que habíamos dejado mi pasaporte en el hotel. Fue un momento de mucho estrés y pensé que iba a perder mi vuelo. Félix actuó de inmediato, sin dudarlo, y logró llevarme el pasaporte al aeropuerto a tiempo para abordar. Su rapidez, amabilidad y compromiso fueron increíbles. No cualquiera haría algo así, y de verdad no tengo palabras para agradecerle lo suficiente. ¡Félix, gracias de corazón! Eres un ejemplo de lo que significa un servicio excepcional. Sin duda volveré a hospedarme en Now Hotel cuando regrese a Cali, y lo recomiendo totalmente a cualquiera que visite la ciudad. ¡Cinco estrellas y más!"
Ninoshtka 3-night trip
Posted 4 days ago
Now Hotel Cali - Adults Only

Frequently asked questions

What's it like in San Antonio?
Travelers to the San Antonio neighborhood in Cali will be sure to enjoy their stay.
What's a favorite place to stay in San Antonio?
Based on our traveler data, Alko Hotel Casa Nispero is one of the top choices for your stay in San Antonio. This hotel offers free breakfast and a restaurant. Another good option for your stay in the area is Viajero Cali Hostel & Salsa School.
How many hotels should I expect to find in the San Antonio area?
If you're searching for places to stay in Cali, Expedia has something to meet your needs with 52 San Antonio hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in San Antonio, will I receive a refund?
Yes, most room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available in San Antonio.
Where can I learn more about changing or cancelling my trip to San Antonio?
For additional details about updating your trip to San Antonio or cancelling it, head over to our customer service page.
What can I see and do in this Cali neighborhood?
Centro Cultural de Cali, Religious Art Museum, and Enrique Buenaventura Municipal Theater are just a few of the places to visit in and around San Antonio. While you're out sightseeing, La Merced Archaeological Museum and Calima Gold Museum of the Bank of the Republic are a couple of additional sights to visit in Cali.