An aerial view of a historic city center with terracotta-roofed buildings, a prominent red-brick structure, and modern high-rises in the background.

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Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

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Our top choices for San Antonio hotels

An outdoor patio with a glass table and chairs, surrounded by lush greenery and illuminated by green lighting.

1. Alko Hotel Casa Nispero

Alko Hotel Casa Nispero
4.0 star property
San Antonio
9.4 out of 10, Exceptional, (249 reviews)
"Excellent. Location, location, location...the best"
United States
ALVARO
The price is AED 556
AED 556 total
19 Oct - 20 Oct
Alko Hotel Casa Nispero
A lobby with a fountain, indoor plants, a dining area, and a painting of a house on the wall.

2. San Antonio Hotel Boutique

San Antonio Hotel Boutique
3.0 star property
San Antonio
9.2 out of 10, Wonderful, (69 reviews)
"The location was excellent, within close distance to many good restaurants. The breakfast was good, with fruit and made to order eggs. The AC was quite adequate. "
United States
Jung
The price is AED 275
AED 344 total
6 Nov - 7 Nov
San Antonio Hotel Boutique
A modern living room with a sofa, a coffee table, and decorative items.

3. Hotel habitat san antonio

Hotel habitat san antonio
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Personal muy servicial y atenta"
Colombia
Giovanny
The price is AED 184
AED 184 total
12 Oct - 13 Oct
Hotel habitat san antonio
An indoor dining area with tables and chairs, surrounded by hanging plants and greenery.

4. Viajero Cali Hostel & Salsa School

Viajero Cali Hostel & Salsa School
2.0 star property
San Antonio
9.0 out of 10, Wonderful, (69 reviews)
"Excellent stay. I stayed in a private room which was small, basic but comfortable. The staff were friendly. The hostel is in a excellent location close to restaurants, bars and attractions. The extra activities and the salsa school were amazing."
Australia
Jasmine
The price is AED 182
AED 182 total
12 Oct - 13 Oct
Viajero Cali Hostel & Salsa School
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.

5. Hotel Casa Bresse

Hotel Casa Bresse
2.5 star property
San Antonio
9.2 out of 10, Wonderful, (5 reviews)
"I am frequent in this hotel , pure colonial beauty with an inside court. Clean , spacious rooms, hot water . Staff friendly and helpful , hotel is close to everything Cali has to offer. Love it."
Canada
Stanislaw
The price is AED 164
AED 164 total
19 Oct - 20 Oct
Hotel Casa Bresse
A modern kitchen with a central island, two wicker bar stools, a red pendant light, and a large window with a view.

6. Epifania Guest House

Epifania Guest House
1.0 star property
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Me gustó todo, muy bien ambiente, excelente trato, muy limpio....."
Mexico
David Alejandro
The price is AED 81
AED 81 total
13 Oct - 14 Oct
Epifania Guest House
A hallway with a large potted plant, a wooden bench, and a chandelier.

7. Casa feliz

Casa feliz
1.0 star property
San Antonio
The price is AED 56
AED 56 total
1 Nov - 2 Nov
Casa feliz
A stone fountain with a child statue, surrounded by potted plants and a tiled wall with a window and a framed picture.

8. casa hostal ave maria san antonio cali

casa hostal ave maria san antonio cali
2.0 star property
San Antonio
4.0 out of 10, (2 reviews)
"Cheap and convenient location. But mosquitoes in room every night and leaky toilet. There are better options available. "
Australia
Meyer
The price is AED 60
AED 60 total
12 Oct - 13 Oct
casa hostal ave maria san antonio cali
A swimming pool with a tiled deck, a dining area with chairs and a table, and a wall decorated with posters.

9. hotel boutique casa vecchia

hotel boutique casa vecchia
3.0 star property
San Cayetano, 0.4 km from San Antonio
10.0 out of 10, Exceptional, (1 review)
"Todo super bien, buena ubicación"
Colombia
carolina
The price is AED 157
AED 157 total
13 Oct - 14 Oct
hotel boutique casa vecchia
A hotel lobby with a grand chandelier, seating area, and a decorative plant centerpiece.

10. Hotel Dann Carlton Cali

Hotel Dann Carlton Cali
3.5 star property
El Peñon, 0.4 km from San Antonio
8.8 out of 10, Excellent, (485 reviews)
"the best place to stay in Cali"
United States
Sarah
The price is AED 363
AED 363 total
17 Oct - 18 Oct
Hotel Dann Carlton Cali
A hotel with a modern facade, a prominent sign, and a landscaped entrance area.

11. InterContinental Cali by IHG

InterContinental Cali by IHG
4.0 star property
El Peñon, 0.3 km from San Antonio
9.0 out of 10, Wonderful, (1,001 reviews)
"Very good hotel and staff"
United States
Pedro
The price is AED 496
AED 496 total
8 Nov - 9 Nov
InterContinental Cali by IHG
A restaurant with outdoor seating, a brick wall, and hanging lights.

12. Hotel el Peñón By Bithotels

Hotel el Peñón By Bithotels
4.0 star property
El Peñon, 0.4 km from San Antonio
9.0 out of 10, Wonderful, (480 reviews)
"Great hotel, centrally located"
Australia
ross
The price is AED 231
AED 231 total
11 Nov - 12 Nov
Hotel el Peñón By Bithotels
A modern hotel with a flat facade, balconies with plants, and a visible entrance.

13. Hotel Foresto 365

Hotel Foresto 365
4.0 star property
El Peñon, 0.5 km from San Antonio
9.4 out of 10, Exceptional, (70 reviews)
"Staff was super friendly."
United Kingdom
Axel
The price is AED 224
AED 224 total
12 Oct - 13 Oct
Hotel Foresto 365
A rooftop pool with a tiled edge, a sign indicating a Jacuzzi, and a view of a cityscape with buildings and hills in the background.

14. Faranda Collection Cali, a member of Radisson Individuals

Faranda Collection Cali, a member of Radisson Individuals
4.0 star property
0.6 km from San Antonio
9.0 out of 10, Wonderful, (159 reviews)
"Great hotel and staff. Perfect location"
United States
Nicholas
The price is AED 274
AED 274 total
7 Nov - 8 Nov
Faranda Collection Cali, a member of Radisson Individuals
A spacious lobby with a beige sofa, a chandelier, and a reception desk.

15. Hotel Obelisco

Hotel Obelisco
4.0 star property
El Peñon, 0.7 km from San Antonio
8.8 out of 10, Excellent, (553 reviews)
"Amazing place to stay! Staff are super friendly, breakfast is amazing especially the empanadas! Room always clean. We always enjoy our stay here"
Canada
Gabriela
The price is AED 333
AED 333 total
18 Oct - 19 Oct
Hotel Obelisco
A historic building with a central courtyard, stone steps, and a traditional balcony.

16. Hotel Stein Colonial

Hotel Stein Colonial
3.0 star property
Juanambú, 0.6 km from San Antonio
9.4 out of 10, Exceptional, (274 reviews)
"Super friendly staff, beautiful historic hotel, & great location/breakfast!"
United States
kevin
The price is AED 194
AED 194 total
11 Nov - 12 Nov
Hotel Stein Colonial
A modern building with a glass facade, a tree in front, and a sign reading "Cr3A D4-62".

17. Altio hotel

Altio hotel
4.0 star property
El Peñon, 0.7 km from San Antonio
8.8 out of 10, Excellent, (196 reviews)
"It was a really nice stay, and In a very convenient location!"
United States
Manuel
The price is AED 160
AED 160 total
12 Oct - 13 Oct
Altio hotel
A modern indoor space with hanging wicker lamps, large windows, and indoor plants.

18. Now Hotel Cali - Adults Only

Now Hotel Cali - Adults Only
4.0 star property
Juanambú, 1.1 km from San Antonio
8.8 out of 10, Excellent, (502 reviews)
"Very nice hotel in a very nice area, lot of restaurants near by. The staff is very friendly,"
United States
Jean Claude
The price is AED 257
AED 257 total
13 Oct - 14 Oct
Now Hotel Cali - Adults Only
A modern outdoor patio area with a staircase leading to an upper level, a seating area with chairs, and a bar counter.

19. Hampton by Hilton Cali, Colombia

Hampton by Hilton Cali, Colombia
4.0 star property
1.1 km from San Antonio
9.0 out of 10, Wonderful, (672 reviews)
"The Staff was outstanding, especially the Manager Andres. Great checkin, great service."
United States
Michael
The price is AED 289
AED 289 total
17 Oct - 18 Oct
Hampton by Hilton Cali, Colombia
A hotel lobby with a grand chandelier, seating area, and a decorative plant centerpiece.

20. Hotel Dann Cali

Hotel Dann Cali
3.0 star property
El Peñon, 0.4 km from San Antonio
8.6 out of 10, Excellent, (613 reviews)
"Nice hotel, nice buffet, excellent location and friendly staff, definitely I'll come back"
United States
Holmes
The price is AED 276
AED 276 total
17 Oct - 18 Oct
Hotel Dann Cali
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in San Antonio

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
An outdoor patio with a glass table and chairs, surrounded by lush greenery and illuminated by green lighting.
Alko Hotel Casa Nispero
4.0 star property
9.4
Exceptional
249 reviews
View
A lobby with a fountain, indoor plants, a dining area, and a painting of a house on the wall.
San Antonio Hotel Boutique
3.0 star property
9.2
Wonderful
69 reviews
View
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.
Hotel Casa Bresse
2.5 star property
9.2
Wonderful
5 reviews
View
An indoor dining area with tables and chairs, surrounded by hanging plants and greenery.
Viajero Cali Hostel & Salsa School
2.0 star property
9.0
Wonderful
69 reviews
View
A modern kitchen with a central island, two wicker bar stools, a red pendant light, and a large window with a view.
Epifania Guest House
1.0 star property
10.0
Exceptional
1 review
View

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most.
A cityscape with dense urban buildings, a prominent hill, and a distant mountain range under a cloudy sky.

Ciudad Jardín

Unique features of Ciudad Jardín include the restaurants and shopping. Make a stop by Palmas Mall or Las Velas Shopping Center while you're exploring the area.

A yellow monument with a bell, surrounded by trees and a fence.

Granada

Visitors to Granada enjoy its shopping, and if you want to do some exploring, Lugar a Dudas is worth a stop.

An aerial view of a city with dense high-rise buildings, a roundabout, and surrounding greenery.

El Peñon

When in El Peñon, you can plan a visit to Gato de Tejada Monument and Calima Gold Museum of the Bank of the Republic, some noteworthy sights in the nearby area.

Pance

Pance might not have many top sights, but Chorrera del Indio and Los Arrayanes Recreational Center are two attractions nearby that you can check out.

Top San Antonio Hotel Reviews

NH Cali Royal

NH Cali Royal

10/10 Excellent
"Me Encanto todo como siempre bien limpio el staff siempres atentos y todo de lo mejor mi segunda vez y volvere muchas gracias por la atencion 👍👌"
Cesar 7-night trip
Posted 17 hours ago
NH Cali Royal

Frequently asked questions

What's it like in San Antonio?
Travelers to the San Antonio neighborhood in Cali will be sure to enjoy their stay.
What's a favorite place to stay in San Antonio?
Based on our traveler data, Alko Hotel Casa Nispero is one of the top choices for your stay in San Antonio. This hotel offers free breakfast and a restaurant. Another good option for your stay in the area is Viajero Cali Hostel & Salsa School.
How many hotels should I expect to find in the San Antonio area?
If you're searching for places to stay in Cali, Expedia has something to meet your needs with 52 San Antonio hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in San Antonio, will I receive a refund?
Yes, most room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available in San Antonio.
Where can I learn more about changing or cancelling my trip to San Antonio?
For additional details about updating your trip to San Antonio or cancelling it, head over to our customer service page.
What can I see and do in this Cali neighborhood?
Centro Cultural de Cali, Religious Art Museum, and Enrique Buenaventura Municipal Theater are just a few of the places to visit in and around San Antonio. While you're out sightseeing, La Merced Archaeological Museum and Calima Gold Museum of the Bank of the Republic are a couple of additional sights to visit in Cali.