An aerial view of a historic city center with terracotta-roofed buildings, a prominent red-brick structure, and modern high-rises in the background.

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Next weekend
6 Nov - 8 Nov
In two weeks
13 Nov - 15 Nov

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Our top choices for San Antonio hotels

A spiral staircase in a courtyard surrounded by lush greenery and concrete structures.

1. Alko Hotel Casa Nispero

Alko Hotel Casa Nispero
4.0 star property
San Antonio
9.4 out of 10, Exceptional, (251 reviews)
"Excellent. Location, location, location...the best"
United States
ALVARO
The price is AED 499
AED 499 total
4 Nov - 5 Nov
Alko Hotel Casa Nispero
A spacious lobby with a central fountain, multiple artworks, and a reception desk.

2. San Antonio Hotel Boutique

San Antonio Hotel Boutique
3.0 star property
San Antonio
9.2 out of 10, Wonderful, (70 reviews)
"Great place to explore the city culture."
United States
Yenny
The price is AED 261
AED 330 total
4 Nov - 5 Nov
San Antonio Hotel Boutique
A hotel room with two beds, a nightstand with a lamp, and a mural of a cityscape on the wall.

3. Hotel habitat san antonio

Hotel habitat san antonio
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Personal muy servicial y atenta"
Colombia
Giovanny
The price is AED 184
AED 184 total
9 Nov - 10 Nov
Hotel habitat san antonio
Pool

4. Viajero Cali Hostel & Salsa School

Viajero Cali Hostel & Salsa School
2.0 star property
San Antonio
9.0 out of 10, Wonderful, (70 reviews)
"Excellent stay. I stayed in a private room which was small, basic but comfortable. The staff were friendly. The hostel is in a excellent location close to restaurants, bars and attractions. The extra activities and the salsa school were amazing."
Australia
Jasmine
The price is AED 202
AED 202 total
16 Nov - 17 Nov
Viajero Cali Hostel & Salsa School
A bedroom with a bed, a desk, a chair, and a small table.

5. Our Home San Antonio

Our Home San Antonio
2.5 star property
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Super friendly staff. Good food. Great frozen coffee. Nice location, closed to major city attractions."
United States
gloria
The price is AED 96
AED 154 total
5 Nov - 6 Nov
Our Home San Antonio
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.

6. Hotel Casa Bresse

Hotel Casa Bresse
2.5 star property
San Antonio
9.2 out of 10, Wonderful, (5 reviews)
"I am frequent in this hotel , pure colonial beauty with an inside court. Clean , spacious rooms, hot water . Staff friendly and helpful , hotel is close to everything Cali has to offer. Love it."
Canada
Stanislaw
The price is AED 162
AED 162 total
6 Nov - 7 Nov
Hotel Casa Bresse
A modern kitchen with a central island, two wicker bar stools, a red pendant light, and a large window with a view.

7. Epifania Guest House

Epifania Guest House
1.0 star property
San Antonio
10.0 out of 10, Exceptional, (1 review)
"Me gustó todo, muy bien ambiente, excelente trato, muy limpio....."
Mexico
David Alejandro
The price is AED 90
AED 90 total
14 Nov - 15 Nov
Epifania Guest House
A stone fountain with a child statue, surrounded by potted plants and a tiled wall with a window and a framed picture.

8. casa hostal ave maria san antonio cali

casa hostal ave maria san antonio cali
2.0 star property
San Antonio
4.0 out of 10, (2 reviews)
"Cheap and convenient location. But mosquitoes in room every night and leaky toilet. There are better options available. "
Australia
Meyer
The price is AED 57
AED 57 total
3 Nov - 4 Nov
casa hostal ave maria san antonio cali
A swimming pool with a tiled deck, a dining area with chairs and a table, and a wall decorated with posters.

9. hotel boutique casa vecchia

hotel boutique casa vecchia
3.0 star property
San Cayetano, 0.4 km from San Antonio
10.0 out of 10, Exceptional, (1 review)
"Todo super bien, buena ubicación"
Colombia
carolina
The price is AED 151
AED 151 total
14 Nov - 15 Nov
hotel boutique casa vecchia
A swimming pool with a water feature, surrounded by palm trees and hotel buildings.

10. InterContinental Cali by IHG

InterContinental Cali by IHG
4.0 star property
El Peñon, 0.3 km from San Antonio
9.0 out of 10, Wonderful, (1,002 reviews)
"todo excelente"
Mexico
ALFREDO
The price is AED 514
AED 514 total
21 Nov - 22 Nov
InterContinental Cali by IHG
A hotel lobby with a grand chandelier, seating area, and a decorative plant centerpiece.

11. Hotel Dann Carlton Cali

Hotel Dann Carlton Cali
3.5 star property
El Peñon, 0.4 km from San Antonio
8.8 out of 10, Excellent, (489 reviews)
"the best place to stay in Cali"
United States
Sarah
The price is AED 367
AED 367 total
8 Nov - 9 Nov
Hotel Dann Carlton Cali
A modern living room with a hammock, a large potted plant, a sofa, and a coffee table.

12. Hotel el Peñón By Bithotels

Hotel el Peñón By Bithotels
4.0 star property
El Peñon, 0.4 km from San Antonio
9.0 out of 10, Wonderful, (485 reviews)
"Great hotel, centrally located"
Australia
ross
The price is AED 241
AED 241 total
18 Nov - 19 Nov
Hotel el Peñón By Bithotels
A rooftop pool with a tiled edge, a sign indicating a Jacuzzi, and a view of a cityscape with buildings and hills in the background.

13. Faranda Collection Cali, a member of Radisson Individuals

Faranda Collection Cali, a member of Radisson Individuals
4.0 star property
La Merced, 0.6 km from San Antonio
9.0 out of 10, Wonderful, (160 reviews)
"Great hotel and staff. Perfect location"
United States
Nicholas
The price is AED 397
AED 397 total
20 Nov - 21 Nov
Faranda Collection Cali, a member of Radisson Individuals
A spacious lobby with a beige sofa, a chandelier, and a reception desk.

14. Hotel Obelisco

Hotel Obelisco
4.0 star property
El Peñon, 0.7 km from San Antonio
8.8 out of 10, Excellent, (557 reviews)
"Great customer service, very clean and good food"
United States
James
The price is AED 271
AED 271 total
21 Nov - 22 Nov
Hotel Obelisco
A hotel with a modern facade, outdoor seating area, and vertical gardens.

15. Hotel Foresto 365

Hotel Foresto 365
4.0 star property
El Peñon, 0.5 km from San Antonio
9.6 out of 10, Exceptional, (72 reviews)
"I Definitely recommend it"
United States
Juan
The price is AED 253
AED 253 total
5 Nov - 6 Nov
Hotel Foresto 365
A bedroom with a large bed, two nightstands, and a wall-mounted painting of a cat.

16. Hotel Casa Murano JLS

Hotel Casa Murano JLS
2.0 star property
La Merced, 0.5 km from San Antonio
The price is AED 163
AED 163 total
1 Nov - 2 Nov
Hotel Casa Murano JLS
A historic building with a central courtyard, stone steps, and a traditional balcony.

17. Hotel Stein Colonial

Hotel Stein Colonial
3.0 star property
Juanambú, 0.6 km from San Antonio
9.4 out of 10, Exceptional, (276 reviews)
"The whole place is pretty clean. Staff is always willing to help with any need, they are very kind. Food is delicious. This place feels like home. I will return to this hotel with no doubt, It is a beautiful ancient building that looks like a castle. I highly recommend this hotel."
Canada
CLAUDIA
The price is AED 200
AED 200 total
15 Nov - 16 Nov
Hotel Stein Colonial
A dining area with wooden chairs and tables, a central plant, and wall-mounted lights.

18. NH Boulevard Del Río Cali

NH Boulevard Del Río Cali
3.5 star property
Centenario, 0.7 km from San Antonio
9.0 out of 10, Wonderful, (389 reviews)
"Constable bed, dark and quiet room, the staff was very nice and always willing to help."
United States
Regis
The price is AED 309
AED 309 total
29 Nov - 30 Nov
NH Boulevard Del Río Cali
A modern building with a glass facade, a tree in front, and a sign reading "Cr3A D4-62".

19. Altio hotel

Altio hotel
4.0 star property
El Peñon, 0.7 km from San Antonio
8.8 out of 10, Excellent, (201 reviews)
"It was a really nice stay, and In a very convenient location!"
United States
Manuel
The price is AED 165
AED 165 total
3 Nov - 4 Nov
Altio hotel
A modern outdoor patio area with a staircase leading to an upper level, a seating area with chairs, and a bar counter.

20. Hampton by Hilton Cali, Colombia

Hampton by Hilton Cali, Colombia
4.0 star property
1.1 km from San Antonio
9.0 out of 10, Wonderful, (679 reviews)
"The Staff was outstanding, especially the Manager Andres. Great checkin, great service."
United States
Michael
The price is AED 295
AED 295 total
21 Nov - 22 Nov
Hampton by Hilton Cali, Colombia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in San Antonio

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spiral staircase in a courtyard surrounded by lush greenery and concrete structures.
Alko Hotel Casa Nispero
4.0 star property
9.4
Exceptional
251 reviews
View
A spacious lobby with a central fountain, multiple artworks, and a reception desk.
San Antonio Hotel Boutique
3.0 star property
9.2
Wonderful
70 reviews
View
A courtyard with a wooden table and chairs, surrounded by potted plants and a climbing plant wall.
Hotel Casa Bresse
2.5 star property
9.2
Wonderful
5 reviews
View
Pool
Viajero Cali Hostel & Salsa School
2.0 star property
9.0
Wonderful
70 reviews
View
A bedroom with a bed, a desk, a chair, and a small table.
Our Home San Antonio
2.5 star property
10.0
Exceptional
1 review
View

Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most.
A cityscape with dense urban buildings, a prominent hill, and a distant mountain range under a cloudy sky.

Ciudad Jardín

Unique features of Ciudad Jardín include the restaurants and shopping. Make a stop by Palmas Mall or Las Velas Shopping Center while you're exploring the area.

A yellow monument with a bell, surrounded by trees and a fence.

Granada

Visitors to Granada enjoy its shopping, and if you want to do some exploring, Lugar a Dudas is worth a stop.

An aerial view of a city with dense high-rise buildings, a roundabout, and surrounding greenery.

El Peñon

When in El Peñon, you can plan a visit to Gato de Tejada Monument and Calima Gold Museum of the Bank of the Republic, some noteworthy sights in the nearby area.

Pance

Pance might not have many top sights, but Chorrera del Indio and Los Arrayanes Recreational Center are two attractions nearby that you can check out.

Top San Antonio Hotel Reviews

NH Cali Royal

NH Cali Royal

10/10 Excellent
"We had a wonderful experience at the NH hotel! The staff was exceptionally friendly, knowledgeable, and always willing to go above and beyond to help. Our room was spotless and very well-maintained, with excellent daily housekeeping service. The breakfast was absolutely delicious, with a wonderful variety of food to choose from. The breakfast staff was also very professional, attentive, and welcoming. We truly enjoyed our stay and couldn’t have asked for a better experience. We would definitely recommend this hotel to anyone looking for a comfortable and enjoyable stay. We look forward to returning!"
Maria C Aragon 14-night trip
Posted 5 hours ago
NH Cali Royal

Frequently asked questions

What's it like in San Antonio?
Travelers to the San Antonio neighborhood in Cali will be sure to enjoy their stay.
What's a favorite place to stay in San Antonio?
Based on our traveler data, Alko Hotel Casa Nispero is one of the top choices for your stay in San Antonio. This hotel offers free breakfast and a restaurant. Another good option for your stay in the area is Viajero Cali Hostel & Salsa School.
How many hotels should I expect to find in the San Antonio area?
If you're searching for places to stay in Cali, Expedia has something to meet your needs with 52 San Antonio hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in San Antonio, will I receive a refund?
Yes, most room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available in San Antonio.
Where can I learn more about changing or cancelling my trip to San Antonio?
For additional details about updating your trip to San Antonio or cancelling it, head over to our customer service page.
What can I see and do in this Cali neighborhood?
Centro Cultural de Cali, Religious Art Museum, and Enrique Buenaventura Municipal Theater are just a few of the places to visit in and around San Antonio. While you're out sightseeing, La Merced Archaeological Museum and Calima Gold Museum of the Bank of the Republic are a couple of additional sights to visit in Cali.