
Find Resorts & Hotels with Spas in Cape Girardeau, MO
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Our top choices for Cape Girardeau hotels with a spa

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
The price is AED 378
AED 427 total
includes taxes & fees
5 Apr - 6 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Cape Girardeau Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent

Drury Inn & Suites Cape Girardeau
10/10 Excellent
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Explore more hotels
- The Twisted Sassafras Treehouse
- 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
- “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Little Blue Cottage on Spanish
- 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
- Rockwood Inn
- Downtown Cape 2 Bdrm/2 Bath Apt, Cozy & Walkable
- 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
- Historical 'Kage House' Short Term Rental located in "Old Town Cape"
- Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Drury Inn & Suites Jackson MO
- Comfort Suites Jackson-Cape Girardeau
- New cabin in the woods with private hot tub
- Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- Hot Tub - Minutes from Winetrail, SIU, Giant City, Cedar Lake, Shawnee Forest!


