A calm body of water, a sandy beach, and a forested area in the distance.

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Our top choices for Cape Girardeau hotels with a spa

Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,003 reviews)
  • cleanliness
    Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
The price is AED 363
AED 410 total
includes taxes & fees
16 Jul - 17 Jul
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Cape Girardeau

Pool
Breakfast included

Top Cape Girardeau Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great location excellent staff very clean room, great breakfast from 7–10 am, 5:30-7 Happy Hr w/ snack food.."
John 1-night trip
Posted 22 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Clean room. Helpful staff."
Marie 3-night trip
Posted 4 days ago
Drury Inn & Suites Cape Girardeau

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Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 66 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit eDen Spa & Salon, Century Casino & Hotel Cape Girardeau, and Cape Splash Family Aquatic Center. If you have a bit of extra time while you're in the area, you might want to check out Hunter Valley Winery and Trail of Tears State Park.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.