A calm body of water, a sandy beach, and a forested area in the distance.

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Check prices for these dates

In two weeks
30 Oct - 1 Nov
In two months
11 Dec - 13 Dec
In three months
8 Jan - 10 Jan
In four months
5 Feb - 7 Feb

Our top choices for Cape Girardeau vacation homes

A living room with a TV, a fireplace, a sofa, and wall art.

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is AED 298
AED 397 total
includes taxes & fees
25 Oct - 26 Oct
Little Blue Cottage on Spanish
A bunk bed with a wooden frame, a mattress, pillows, and a blanket.

2. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is AED 377
AED 691 total
includes taxes & fees
17 Nov - 18 Nov
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Exterior

3. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is AED 570
AED 834 total
includes taxes & fees
18 Oct - 19 Oct
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Ground floor of the Euro

4. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is AED 570
AED 816 total
includes taxes & fees
25 Oct - 26 Oct
The Little Château | Woodland Escape
Exterior

5. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is AED 591
AED 842 total
includes taxes & fees
18 Oct - 19 Oct
The Little Cape Lofted Cottage | Creek & Nature
A two-story house with a front porch, a small garden, and a white picket fence.

6. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is AED 658
AED 1,158 total
includes taxes & fees
18 Oct - 19 Oct
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
A modern kitchen with a large island, white cabinetry, and a brick accent wall.

7. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is AED 735
AED 1,150 total
includes taxes & fees
26 Oct - 27 Oct
Beautifully Renovated Farmhouse in Jackson, MO
A house with a backyard swimming pool, outdoor furniture, and a barbecue area.

8. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is AED 1,319
AED 2,133 total
includes taxes & fees
18 Oct - 19 Oct
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
A wooden cabinet with a microwave, coffee maker, and plates.

9. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (27 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is AED 347
AED 601 total
includes taxes & fees
20 Oct - 21 Oct
Cozy and Updated Farmhouse with King Suite
A brick building with a sign reading "1898 Guesthouse".

10. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (15 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
United States
Dylan
The price is AED 505
AED 1,049 total
includes taxes & fees
21 Oct - 22 Oct
Stunning 2 bedroom in town, close to Shawnee National Forest
A kitchen with wooden cabinets, a countertop, and a window with blinds.

11. Crossview Cottage - Direct view of Bald Knob Cross

Crossview Cottage - Direct view of Bald Knob Cross
Alto Pass
10.0 out of 10, Exceptional, (1 review)
"Quiet, private, and perfect for one or two adults!"
United States
Anthony R.
The price is AED 422
AED 547 total
includes taxes & fees
26 Oct - 27 Oct
Crossview Cottage - Direct view of Bald Knob Cross
A large, two-story house with a wrap-around porch, surrounded by a well-maintained garden with various flowering plants.

12. Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
9.8 out of 10, Exceptional, (19 reviews)
"Everything was beautiful, and although we weren’t there for a long time, enjoyed an Incredible sleep in the most comfortable beds!"
United States
Rachel H.
The price is AED 652
AED 1,288 total
includes taxes & fees
19 Oct - 20 Oct
Magical Victorian near hiking / wine trail
A spacious living area with a kitchen, a dining table, and comfortable seating.

13. Peach Tree Inn, downtown Cobden

Peach Tree Inn, downtown Cobden
Cobden
10.0 out of 10, Exceptional, (3 reviews)
"Amazing place to stay. Excellent location, beautiful rooms and accommodation and the host was so responsive. We will definitely be back!"
United States
Rebecca L.
The price is AED 698
AED 850 total
includes taxes & fees
18 Oct - 19 Oct
Peach Tree Inn, downtown Cobden
A spacious living room with a brown leather sofa, a dining area with a wooden table and chairs, a kitchen with white cabinets and a central island, and large windows with blinds.

14. Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
Anna
10.0 out of 10, Exceptional, (12 reviews)
"Clean, attentive host, shops near by, family friendly "
United States
Molly J.
The price is AED 456
AED 997 total
includes taxes & fees
19 Oct - 20 Oct
Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
A wooden deck with two white Adirondack chairs and a small round table.

15. Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Alto Pass
10.0 out of 10, Exceptional, (5 reviews)
"The house was very welcoming and clean. Very inviting for our short stay. "
United States
brian O.
The price is AED 643
AED 964 total
includes taxes & fees
20 Oct - 21 Oct
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
A covered porch with a wooden railing, a table with chairs, and a sofa.

16. Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
9.8 out of 10, Exceptional, (83 reviews)
"This rental was very clean, pet friendly, and definitely secluded. We enjoyed our stay here."
United States
Candi M.
The price is AED 356
AED 654 total
includes taxes & fees
19 Oct - 20 Oct
Beautiful location in the secluded woods
A red barn-style building with a sign reading "Farm Market" and a stage with chairs and a table.

17. Farm Fresh Eggs, Golf Cart, Telescope

Farm Fresh Eggs, Golf Cart, Telescope
Alto Pass
9.8 out of 10, Exceptional, (15 reviews)
"It’s a very cute old farm house nestled in a peach orchard! Rolling hills with a porch swing that overlooks the orchards and a pond. The hosts provide all of the essential's for a comfortable stay! Communication is wonderful from beginning to the end! Would stay here again and again!"
United States
Gary A.
The price is AED 788
AED 981 total
includes taxes & fees
17 Nov - 18 Nov
Farm Fresh Eggs, Golf Cart, Telescope
Interior

18. Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda

Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda
Makanda
10.0 out of 10, Exceptional, (1 review)
"We will definitely book our next stay with this home as it was very very clean and had everything we needed for our stay. The host is very easy to communicate with, even though we didn't need to contact her about anything during our stay because everything was perfect. Having a garage to park in was definitely a plus. The king beds were comfy and the kitchen was stock with everything that we needed. Thanks again."
United States
Rosa R.
The price is AED 461
AED 567 total
includes taxes & fees
18 Oct - 19 Oct
Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda
A spacious living area with a kitchen, a dining table, and comfortable seating.

19. Heart of Wine country in Cobden

Heart of Wine country in Cobden
Cobden
10.0 out of 10, Exceptional, (1 review)
"We throughly enjoyed the accommodations and plan I. Returning! Checking in was easy, and they worked with us on an earlier check in. Checking out process was very smooth and easy. We can’t wait to book our next trip."
United States
CHEA M.
The price is AED 698
AED 850 total
includes taxes & fees
18 Oct - 19 Oct
Heart of Wine country in Cobden
A spacious living area with a kitchen, a dining table, and comfortable seating.

20. King Suite, Hot Tubs, Cobden

King Suite, Hot Tubs, Cobden
Cobden
The price is AED 698
AED 850 total
includes taxes & fees
18 Oct - 19 Oct
King Suite, Hot Tubs, Cobden
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great as usual"
Frank 1-night trip
Posted 11 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center