4/5 - Good
Verified traveler
Due to the coronavirus, we didn't really have an opportunity to check out Cape Girardeau, visiting with friends in their home instead. Next time though!
Cape Girardeau, MO
Travel Guide
Visit Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
The price is AED 331 per night from Jun 8 to Jun 9
AED 331
AED 373 total
includes taxes & fees
8 Jun - 9 Jun
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,007 reviews)
"Great place to get off the road and stay! The staff was incredibly friendly! And the breakfast is hand cooked not processed breakfast food."
Reviewed on 30 May 2025
The Riverview
777 Main St, Cape Girardeau, MO
The price is AED 430 per night from Jun 3 to Jun 4
AED 430
AED 485 total
includes taxes & fees
3 Jun - 4 Jun
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (280 reviews)
"Great property"
Reviewed on 31 May 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
The price is AED 215 per night from Jun 8 to Jun 9
AED 215
AED 242 total
includes taxes & fees
8 Jun - 9 Jun
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)
"Clean and comfortable"
Reviewed on 26 May 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
The Twisted Sassafras Treehouse
Cape Girardeau
Stay at this cabin in Cape Girardeau. Enjoy a garden, patios, and an in-room coffeemaker. Popular attractions Cape Girardeau Conservation Nature Center and Cape ...
Great spot for a romantic retreat!
"My wife and I thoroughly enjoyed our stay here! A beautiful place built on a beautiful property; we enjoyed the hot tub under the stars and the morning coffee on the porch (and another hot tub ). Great place for some R&R, and excellent communication with the owner in advance. Wouldn’t hesitate to ..."
Reviewed on 28 March 2025
Quaint, Beautiful Home next to SEMO and Hospital
Cape Girardeau
Stay at this vacation home in Cape Girardeau. Enjoy laundry facilities, an in-room coffeemaker, and in-room fireplaces. Popular attractions Show Me Center and ...
9.8/10 Exceptional! (35 reviews)
Perfect spot
"Quaint, little property with roomy accommodations. So much better than 4 people sharing a hotel room…everyone had their own space. The location was convenient, quiet and the neighborhood felt safe."
Reviewed on 28 May 2025
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Cape Girardeau
Book a stay at this family-friendly vacation home in Cape Girardeau. Enjoy free WiFi, a water park, and a garden. Popular attractions Isle Casino Cape Girardeau ...
10/10 Exceptional! (15 reviews)
So much charm!
"Lovely home perfect for our weekend celebrating our daughter’s graduation. Chip was an excellent host, even found us champagne flutes! Beds were comfortable, house was clean and nicely decorated."
Reviewed on 15 May 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Southeast Missouri State University
4.5/5(76 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Isle Casino Cape Girardeau
4.5/5(48 reviews)
Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Riverfront Bridge Park
4.5/5(43 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Saint Francis Medical Center
Though Saint Francis Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Cape Girardeau while you are here.
Cape Splash Family Aquatic Center
4.5/5(4 reviews)
Bring the family to Cape Splash Family Aquatic Center and enjoy this exciting amusement park in Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Show Me Center
Catch an event at Show Me Center during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Reviews of Cape Girardeau
4.3
Top Destination
5/5 - Excellent
Verified traveler
We appreciated the close proximity of dining options enabling us to walk rather than getting back in the car after a long travel day.
3/5 - Okay
Verified traveler
I live here. Reason for the hotel was so my daughter could swim with her friends. And have a small birthday pool party and get out of the house for a night
5/5 - Excellent
Verified traveler
Just loved it all, the people,place's it was just wonderful..
5/5 - Excellent
Verified traveler
Love this city. Go see the bridge over into IL - beautiful!!! The city is a very pleasant place to visit.
4/5 - Good
Verified traveler
I really enjoyed the Missouri Wall of Fame.
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Cape Splash Family Aquatic Center
- Riverfront Park
- Hunter Valley Winery
- Cape Rock Park
- eDen Spa & Salon
- Cape Girardeau Conservation Nature Center
- Lazy L Safari Park
- Fort D Historic Site
- Shawnee National Forest
- Mississippi River
- Trail of Tears State Park