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Check prices for these dates

Next weekend
19 Dec - 21 Dec
In two weeks
26 Dec - 28 Dec
In one month
9 Jan - 11 Jan
In two months
6 Feb - 8 Feb

Our top choices for Defiance bed & breakfast

Front of property
Central Hotel

Central Hotel

3.5 star property
New Haven
9.8 out of 10, Exceptional, (115)
"We loved it "
United States
Kaitlyn
The price is AED 569
AED 622 total
includes taxes & fees
11 Dec - 12 Dec
Central Hotel
Interior
The Cyclist! Katy Trail comfort in Marthasville,MO

The Cyclist! Katy Trail comfort in Marthasville,MO

Marthasville
9.8 out of 10, Exceptional, (10)
"Wonderful place to get away to and relax!"
United States
Timothy J.
The price is AED 562
AED 869 total
includes taxes & fees
10 Jan - 11 January 2026
The Cyclist! Katy Trail comfort in Marthasville,MO
Property grounds
Pinckney Bend Bed & Breakfast

Pinckney Bend Bed & Breakfast

3.0 star property
New Haven
9.6 out of 10, Exceptional, (116)
"Wonderful stay! "
United States
Brynn Elizabeth
The price is AED 507
AED 554 total
includes taxes & fees
15 Dec - 16 Dec
Pinckney Bend Bed & Breakfast
1 bedroom, bed sheets
Wine Haus: charming cottage with breathtaking views of the Missouri River!!

Wine Haus: charming cottage with breathtaking views of the Missouri River!!

2.0 star property
New Haven
10.0 out of 10, Exceptional, (2)
"Lived the scenery and decor. Hosts were lovely!! Vern nice breakfast!!"
United States
Margie P.
The price is AED 606
AED 838 total
includes taxes & fees
17 Dec - 18 Dec
Wine Haus: charming cottage with breathtaking views of the Missouri River!!
Interior
The Wineaux! Wine Country charm in Marthasville,MO

The Wineaux! Wine Country charm in Marthasville,MO

Marthasville
9.2 out of 10, Wonderful, (10)
"This is a really nice place in a nice little community. We stayed here for a ride on the Katy trail and enjoyed it a lot. "
United States
Clint H.
The price is AED 562
AED 869 total
includes taxes & fees
10 Jan - 11 January 2026
The Wineaux! Wine Country charm in Marthasville,MO
Exterior detail
TheOutPostInn Bed&Breakfast - The Blue Victorian

TheOutPostInn Bed&Breakfast - The Blue Victorian

Marthasville
8.6 out of 10, Excellent, (7)
"Stayed in Hermann one night and here one night. Great space, comfy bed, quiet area."
United States
Erin A.
The price is AED 400
AED 672 total
includes taxes & fees
11 Dec - 12 Dec
TheOutPostInn Bed&Breakfast - The Blue Victorian
Interior
The Daniel Boone Room -Marthasville,MO

The Daniel Boone Room -Marthasville,MO

Marthasville
8.6 out of 10, Excellent, (8)
"We enjoyed the property. The decor is great and very clean. Location and hospitality was nice. "
United States
Kim B.
The price is AED 444
AED 580 total
includes taxes & fees
11 Dec - 12 Dec
The Daniel Boone Room -Marthasville,MO
Terrace/patio
Fish Haus: charming cottage with breathtaking views of the Missouri River!!

Fish Haus: charming cottage with breathtaking views of the Missouri River!!

New Haven
10.0 out of 10, Exceptional, (14)
"We truly enjoyed our stay and look forward to retuning! "
United States
Leonard L.
The price is AED 606
AED 830 total
includes taxes & fees
21 Dec - 22 Dec
Fish Haus: charming cottage with breathtaking views of the Missouri River!!
Exterior detail
TheOutPostInn Bed&Breakfast - The Purple Victorian

TheOutPostInn Bed&Breakfast - The Purple Victorian

Marthasville
6.0 out of 10, (1)
"It was a small room and had to squeeze between the bed and wall to get in. Almost had to use the foot stool to get in the bed secondary to being so high up and the mattress was extremely firm. The pillows were super soft which did not go with the firm bed, woke up several times in the night to re fluff the pillows and still woke up with a sore neck. The thing that bothered me the most was the curtain in the bathroom was screwed to the wall and you could not close them for privacy. The building...
United States
Michelle G.
The price is AED 465
AED 750 total
includes taxes & fees
11 Dec - 12 Dec
TheOutPostInn Bed&Breakfast - The Purple Victorian
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Front staff was very friendly and very helpful. Check-in and check out was smooth and very easy. "
James 2-night trip
Posted 19 hours ago
Hollywood Casino & Hotel St. Louis

Frequently asked questions

Searching for B&Bs in Defiance?
If you're looking for something a little more offbeat than your standard hotel experience, a bed and breakfast could be the perfect alternative for your getaway. When you want to venture out to explore Defiance, consider browsing the exhibits at Historic Daniel Boone Home and Heritage Center.
Are you thinking about a B&B for your stay?
With attentive service, opportunities to socialize with other guests, and of course a full breakfast to start the day, B&Bs all have a one-of-a-kind environment.
What are the best B&Bs in Defiance?
Below are some B&Bs in the area: The Daniel Boone Room -Marthasville,MO: 15.3 mi (24.6 km) from the downtown core. The Wineaux! Wine Country charm in Marthasville,MO: 15.3 mi (24.6 km) from the heart of downtown.
What's the best time of year to book my B&B in Defiance?
When you're dreaming of a trip to Defiance, year-round temperatures and rainfall may be important factors to consider. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What is there to do in Defiance?
Spend some time exploring Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area if you're hoping to see some of the area's natural features. You might put Yellow Farmhouse Winery and Chandler Hill Vineyards on your list if you want to see more of the area.
How can I get to and around Defiance?
You can plan your excursions in and around Defiance ahead of time with these transportation options. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) away from the heart of the city. Otherwise, look for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to venture out around the area, you may want to rent a car for your trip.