Photo by Michael True

Find hotels in Defiance, MO from AED 257

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
2 Nov - 3 Nov
Tomorrow
3 Nov - 4 Nov
Next weekend
7 Nov - 9 Nov
In two weeks
14 Nov - 16 Nov

Filter by

Guest rating
Guest rating
Star rating

Compare 838 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
8.0 out of 10, Very Good, (1025)
"Good hotel"
United States
Kelly
The price is AED 312
AED 361 total
includes taxes & fees
9 Nov - 10 Nov
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ballroom
The Wildwood Hotel
The Wildwood Hotel
3.5 star property
9.2 out of 10, Wonderful, (1597)
"We enjoyed our stay!"
United States
Michael
The Wildwood Hotel
Front of property
Sonesta ES Suites St. Louis - Chesterfield
Sonesta ES Suites St. Louis - Chesterfield
3.0 star property
8.0 out of 10, Very Good, (1015)
"This was a very nice place to stay. Centrally located, very clean and quiet with a great breakfast!"
United States
Kirsti
The price is AED 341
AED 395 total
includes taxes & fees
12 Nov - 13 Nov
Sonesta ES Suites St. Louis - Chesterfield
Property amenity
Baymont by Wyndham Warrenton
Baymont by Wyndham Warrenton
2.5 star property
7.4 out of 10, Good, (1001)
"Place was fantastic love love love this property"
United States
Adam
The price is AED 314
AED 360 total
includes taxes & fees
9 Nov - 10 Nov
Baymont by Wyndham Warrenton
Front of property
Super 8 by Wyndham Eureka/Six Flags Nearby
Super 8 by Wyndham Eureka/Six Flags Nearby
2.0 star property
7.0 out of 10, Good, (1023)
"Clean rooms fully stocked room with towels "
United States
Paul
The price is AED 220
AED 257 total
includes taxes & fees
1 Dec - 2 Dec
Super 8 by Wyndham Eureka/Six Flags Nearby
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
9.4 out of 10, Exceptional, (817)
"The area around the hotel appeared to be safe and well kept. "
United States
Alice
The price is AED 496
AED 591 total
includes taxes & fees
16 Nov - 17 Nov
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby
Best Western Plus St. Louis West-Westport
Best Western Plus St. Louis West-Westport
2.5 star property
8.0 out of 10, Very Good, (1012)
"It was a very nice place"
United States
Jill
The price is AED 317
AED 368 total
includes taxes & fees
17 Nov - 18 Nov
Best Western Plus St. Louis West-Westport
Lobby
Days Inn by Wyndham St Peters/St Charles
Days Inn by Wyndham St Peters/St Charles
2.0 star property
6.4 out of 10, (1001)
"Decent for the price"
United States
Kathie
The price is AED 231
AED 266 total
includes taxes & fees
17 Nov - 18 Nov
Days Inn by Wyndham St Peters/St Charles
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
8.8 out of 10, Excellent, (1002)
"Friendly/helpful staff!!! Clean and quiet - comfortable beds!!! Great Breakfast options including fresh fruit! Will book again! "
United States
Judy - Walt
The price is AED 321
AED 378 total
includes taxes & fees
5 Nov - 6 Nov
Sleep Inn & Suites O'Fallon MO - Technology Drive
1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds
Best Western Plus Washington Hotel
Best Western Plus Washington Hotel
2.5 star property
9.2 out of 10, Wonderful, (620)
"Great breakfast, comfortable room, and wonderful staff, all for a reasonable price. We stay here every time we are in Washington."
United States
Kimberly
The price is AED 474
AED 539 total
includes taxes & fees
4 Nov - 5 Nov
Best Western Plus Washington Hotel
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
8.6 out of 10, Excellent, (811)
"Clean, well maintained hotel. Friendly staff, great breakfast. Close to shopping and restaurants."
United States
Theresa
The price is AED 349
AED 412 total
includes taxes & fees
9 Nov - 10 Nov
Holiday Inn Express St. Louis West - O'Fallon by IHG
Front of property - evening/night
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 star property
8.4 out of 10, Very Good, (2203)
"Great stay would recommend "
United States
Ross
The price is AED 346
AED 457 total
includes taxes & fees
16 Nov - 17 Nov
Hollywood Casino & Hotel St. Louis
Daily buffet breakfast (USD 12.95 per person)
Hilton Garden Inn Chesterfield
Hilton Garden Inn Chesterfield
3.0 star property
8.2 out of 10, Very Good, (776)
"Staff was courteous. "
United States
John
The price is AED 359
AED 418 total
includes taxes & fees
9 Nov - 10 Nov
Hilton Garden Inn Chesterfield
In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Warrenton
Super 8 by Wyndham Warrenton
2.0 star property
7.4 out of 10, Good, (608)
"Ample free parking for our large RV. Staff was indifferent and acted like they were doing us a favor by letting us stay. Had to wait quite a while to be greeted for check in. Very limited lodging choices in the area, so??"
United States
Gary
The price is AED 225
AED 258 total
includes taxes & fees
9 Nov - 10 Nov
Super 8 by Wyndham Warrenton
Exterior
Hampton Inn St. Charles St. Peters
Hampton Inn St. Charles St. Peters
2.5 star property
8.0 out of 10, Very Good, (1007)
"All around good hotel"
United States
Randy
The price is AED 358
AED 412 total
includes taxes & fees
16 Nov - 17 Nov
Hampton Inn St. Charles St. Peters
Double Room, 2 Double Beds | In-room safe, laptop workspace, blackout drapes, iron/ironing board
Super 8 by Wyndham St. Clair MO
Super 8 by Wyndham St. Clair MO
2.0 star property
7.2 out of 10, Good, (927)
"Very affordable"
United States
Luke
The price is AED 245
AED 268 total
includes taxes & fees
9 Nov - 10 Nov
Super 8 by Wyndham St. Clair MO
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
8.0 out of 10, Very Good, (1083)
"Nice clean rooms."
United States
Chrysta
The price is AED 290
AED 335 total
includes taxes & fees
9 Nov - 10 Nov
Wingate by Wyndham St. Louis/Fenton Route 66
Exterior
Holiday Inn Express & Suites St. Louis West - Fenton by IHG
Holiday Inn Express & Suites St. Louis West - Fenton by IHG
3.0 star property
8.8 out of 10, Excellent, (1013)
"Staff was super friendly "
United States
Melissa
The price is AED 371
AED 428 total
includes taxes & fees
4 Nov - 5 Nov
Holiday Inn Express & Suites St. Louis West - Fenton by IHG
Lobby
AC Hotel by Marriott St. Louis Chesterfield
AC Hotel by Marriott St. Louis Chesterfield
3.5 star property
9.2 out of 10, Wonderful, (216)
"Loved my stay here "
United States
nakia
The price is AED 466
AED 541 total
includes taxes & fees
22 Nov - 23 Nov
AC Hotel by Marriott St. Louis Chesterfield
Lobby
Super 8 by Wyndham Union
Super 8 by Wyndham Union
2.0 star property
8.2 out of 10, Very Good, (626)
"All around great place to stay."
United States
Chris
The price is AED 284
AED 314 total
includes taxes & fees
12 Nov - 13 Nov
Super 8 by Wyndham Union
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Defiance attractions

Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
Bucsh Wildlife lakes are beautiful spots for sunrise or sunset.
Photo by Michael True
Open Photo by Michael True

Top Defiance Hotel Reviews

Courtyard by Marriott St Louis Creve Coeur

Courtyard by Marriott St Louis Creve Coeur

10/10 Excellent
"Very nice, large suite. Clean, comfortable bed. "
Kristopher 1-night trip
Posted 3 days ago
Courtyard by Marriott St Louis Creve Coeur

More cheap stays in Defiance

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive, St. Charles, MO
The price is AED 257 per night from Nov 4 to Nov 5
AED 257
AED 298 total
4 Nov - 5 Nov
includes taxes & fees
5.6/10 (1,025 reviews)

Hotels in Defiance with star-rating

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Sonesta ES Suites St. Louis - Chesterfield and Hollywood Casino & Hotel St. Louis. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
Madison House 2 -Walk to Main St: Visitors like this Defiance vacation home rental. It is equipped with an arcade game room, air-conditioning, and WiFi to help you feel comfortable during your stay. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. Sonesta ES Suites St. Louis - Chesterfield and La Quinta Inn & Suites by Wyndham St. Louis Westport are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

Explore a world of travel with Expedia