Search Vacation Homes in Defiance

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Compare 307 Vacation Homes in Defiance with updated reviews, rates, and availability.

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (97)
"Our second year in a row and we love this place! It is perfect for a girls trip."
The price is AED 422
AED 893 total
includes taxes & fees
16 Jun - 17 Jun
St. Charles 1860's Gem - Sleeps 6!

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (59)
"There was plenty of room to sit with friends in the living room/kitchen. Everything was clean. It was a nice convenient spot to stay! "
The price is AED 716
AED 1,465 total
includes taxes & fees
16 Jun - 17 Jun
Stunning 1890's Home - Sleeps 8!

AK's STL Pearl Grey House - Game Room

9.4 out of 10, Exceptional, (3)
"Quiet neighborhood, comfortable house, well-stocked kitchen. We would stay here again."
AK's STL Pearl Grey House - Game Room

Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

10.0 out of 10, Exceptional, (28)
"Very clean and had everything we needed. TV had a lot of options and overall was very cozy and comfortable. "
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

Downtown St. Charles • Cozy Historic Home

9.8 out of 10, Exceptional, (7)
"We enjoyed our stay in Frenchtown, walking the historic streets, and spending time in old St. Charles which was a short walk away. Our 1800s house was very confortable and provided plenty of room for the 6 of us plus our dogs. The kitchen was well stocked with dishware and cooking items. Beds were comfortable. It was a great home away from home!"
The price is AED 1,098
AED 2,728 total
includes taxes & fees
10 Jun - 11 Jun
Downtown St. Charles • Cozy Historic Home

Downtown Boho Bungalow

10.0 out of 10, Exceptional, (37)
"Property just as listed-our family enjoyed our stay."
Downtown Boho Bungalow

Private St Peters Home Patio Pool Table

10.0 out of 10, Exceptional, (16)
"Very nice house to stay, Highly recommend "
Private St Peters Home Patio Pool Table

Cozy Unit on Historic Main Street

9.4 out of 10, Exceptional, (3)
"Clean, within walking distance to shops and restaurants. "
Cozy Unit on Historic Main Street

☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome

9.0 out of 10, Wonderful, (48)
"Everything was perfect. Thank you so much for everything. "
The price is AED 804
AED 1,578 total
includes taxes & fees
16 Jun - 17 Jun
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome

Charming 3-bedroom house with AC, WiFi in amazing St. Louis

9.0 out of 10, Wonderful, (2)
"Clean and comfortable property close to everywhere we needed to go while there. "
The price is AED 661
AED 1,726 total
includes taxes & fees
9 Jun - 10 Jun
Charming 3-bedroom house with AC, WiFi in amazing St. Louis

Spectacular Innsbrook House on Alpine Lake

10.0 out of 10, Exceptional, (167)
"Beautiful house, beautiful views, even in winter! It was perfect for the 6 of us. Stayed in all weekend (which was what we wanted). Might have to visit in the warmer weather to take advantage of all the outdoor amenities."
Spectacular Innsbrook House on Alpine Lake

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

9.8 out of 10, Exceptional, (60)
"We enjoyed our stay at this property and would recommend it to others!"
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis

9.6 out of 10, Exceptional, (120)
"We really only used it like a hotel but will certainly come back to enjoy the lake. So peaceful and quiet. "
Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis

Charming Home in Cozy Frenchtown Saint Charles

Charming Home in Cozy Frenchtown Saint Charles

Stunning Lakeside Retreat at Innsbrook w/ Swing, Canoe and 3 Kayaks

9.8 out of 10, Exceptional, (48)
"We had a great time. The home was great for our group of 7.! "
Stunning Lakeside Retreat at Innsbrook w/ Swing, Canoe and 3 Kayaks

St. Charles/St. Peters 3 Bedroom Charmer

10.0 out of 10, Exceptional, (25)
"very safe neighborhood at and a very fair price"
St. Charles/St. Peters 3 Bedroom Charmer

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (40)
"My family and I had a wonderful time. The home was clean and just enough space for us all. Would definitely book again. "
The price is AED 575
AED 1,313 total
includes taxes & fees
16 Jun - 17 Jun
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

9.6 out of 10, Exceptional, (46)
"Cozy and comfortable"
The price is AED 691
AED 1,506 total
includes taxes & fees
8 Jun - 9 Jun
Spacious*Outdoor Space*Modern*Family*Groups*Modern*Artistic

1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

10.0 out of 10, Exceptional, (256)
"It was a wonderful getaway it was close to St Peter's Church and downtown."
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.

Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

10.0 out of 10, Exceptional, (27)
"Donna was very nice and the home was perfect for my group’s stay!"
The price is AED 2,387
AED 3,936 total
includes taxes & fees
8 Jun - 9 Jun
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in