A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Defiance Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
7 Aug - 9 Aug
In two months
18 Sep - 20 Sep
In three months
16 Oct - 18 Oct
In four months
13 Nov - 15 Nov

Our top choices for Defiance vacation rentals

Bar (on property)

Aspen Heights by Innsbrook Vacations!

Aspen Heights by Innsbrook Vacations!
Innsbrook
9.0 out of 10, Wonderful, (12 reviews)
"Nice, quiet, relaxing place to stay! Great communication with the host. "
United States
Lorna M.
The price is AED 257
AED 812 total
includes taxes & fees
23 Jul - 24 Jul
Aspen Heights by Innsbrook Vacations!
Property grounds

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
St. Louis
9.0 out of 10, Wonderful, (13 reviews)
"This was absolutely perfect and reasonable pricing I surely will be back "
United States
David G.
The price is AED 275
AED 370 total
includes taxes & fees
9 Aug - 10 Aug
Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
1 bedroom, WiFi (free)

1 Queen Bed | Non-Smoking, Kitchen

1 Queen Bed | Non-Smoking, Kitchen
Westport
9.8 out of 10, Exceptional, (41 reviews)
"I really enjoy it here!"
United States
Anonymous traveler
The price is AED 284
AED 330 total
includes taxes & fees
19 Aug - 20 Aug
1 Queen Bed | Non-Smoking, Kitchen
Exterior

TJ’s Country Getaway- Dog Friendly

TJ’s Country Getaway- Dog Friendly
Union
10.0 out of 10, Exceptional, (50 reviews)
"This was such a cozy and comfortable property. The host provided everything we needed and she was so welcoming. We will stay here again!"
United States
Angela S.
The price is AED 275
AED 606 total
includes taxes & fees
18 Aug - 19 Aug
TJ’s Country Getaway- Dog Friendly
Bar (on property)

Aspen Sights by Innsbrook Vacations!

Aspen Sights by Innsbrook Vacations!
Innsbrook
9.6 out of 10, Exceptional, (14 reviews)
"Lovely weekend- enjoyed checking out Innsbrook"
United States
Denise L.
The price is AED 257
AED 815 total
includes taxes & fees
21 Jul - 22 Jul
Aspen Sights by Innsbrook Vacations!
Bar (on property)

The Harris Overlook by Innsbrook Vacations!

The Harris Overlook by Innsbrook Vacations!
Innsbrook
9.4 out of 10, Exceptional, (21 reviews)
"Great location and property within close distance of all Innsbrook has to offer. Would stay again. "
United States
Kristina U.
The price is AED 257
AED 808 total
includes taxes & fees
21 Jul - 22 Jul
The Harris Overlook by Innsbrook Vacations!
Exterior detail

2nd Street Loft - Riverview

2nd Street Loft - Riverview
Washington
10.0 out of 10, Exceptional, (12 reviews)
"This place was perfect for our weekend getaway! Beautifully decorated and clean! It is also right next to everything in historic downtown Washington, so that we could walk everywhere. "
United States
Tammy H.
The price is AED 313
AED 639 total
includes taxes & fees
21 Jul - 22 Jul
2nd Street Loft - Riverview
Exterior

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.2 out of 10, Wonderful, (36 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
The price is AED 397
AED 838 total
includes taxes & fees
17 Aug - 18 Aug
Stay on Main Historic Studio
Smart TV

Cottage on Historic Main Street- Low Cleaning fee

Cottage on Historic Main Street- Low Cleaning fee
St. Charles Historic District
10.0 out of 10, Exceptional, (20 reviews)
"Great location to Main Street. "
United States
Daneen H.
Cottage on Historic Main Street- Low Cleaning fee
1 bedroom, WiFi (free)

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.8 out of 10, Exceptional, (40 reviews)
"Great spot!"
United States
Anonymous traveler
The price is AED 323
AED 375 total
includes taxes & fees
10 Aug - 11 Aug
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Property grounds

Cozy little house blocks from the Park & Fair Grounds.

Cozy little house blocks from the Park & Fair Grounds.
Washington
10.0 out of 10, Exceptional, (72 reviews)
"Everything was great! From easy check-in, great communication to a very clean and beautiful space we really enjoyed our stay. "
United States
Donna B.
The price is AED 496
AED 993 total
includes taxes & fees
10 Aug - 11 Aug
Cozy little house blocks from the Park & Fair Grounds.
Interior

2 Queen Beds | Non-Smoking, Kitchen

2 Queen Beds | Non-Smoking, Kitchen
Westport
9.8 out of 10, Exceptional, (38 reviews)
"Fantastic place!"
United States
Anonymous traveler
The price is AED 342
AED 396 total
includes taxes & fees
23 Jul - 24 Jul
2 Queen Beds | Non-Smoking, Kitchen
Interior

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (180 reviews)
"Great place to stay. Our go to when visiting St.Charles or STL"
United States
jeramy p.
The price is AED 459
AED 967 total
includes taxes & fees
2 Aug - 3 Aug
The Lofts of North Main Street
Interior

Adorable Augusta Cabin

Adorable Augusta Cabin
Augusta
8.4 out of 10, Very Good, (19 reviews)
"Great little Cabin exactly as described. Weekend getaway with the wife clean and cozy. Would stay again if visiting the wineries "
United States
Michael W.
The price is AED 397
AED 863 total
includes taxes & fees
21 Jul - 22 Jul
Adorable Augusta Cabin
Interior

2 Queen Beds | Mobil Access Tub Nsmk Kitchen

2 Queen Beds | Mobil Access Tub Nsmk Kitchen
Westport
10.0 out of 10, Exceptional, (43 reviews)
"Great place to stay!"
United States
Anonymous traveler
The price is AED 342
AED 396 total
includes taxes & fees
10 Aug - 11 Aug
2 Queen Beds | Mobil Access Tub Nsmk Kitchen
Interior

Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (8 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
The price is AED 481
AED 1,144 total
includes taxes & fees
23 Jul - 24 Jul
Cottage on Main st- Low Cleaning Fee
Interior

Spacious 2 Bedroom Townhome

Spacious 2 Bedroom Townhome
Saint Charles
8.0 out of 10, Very Good, (16 reviews)
"Quiet area and clean rooms"
United States
Chelsie H.
The price is AED 436
AED 1,165 total
includes taxes & fees
21 Jul - 22 Jul
Spacious 2 Bedroom Townhome
Exterior

Rustic Augusta Wood Cabin

Rustic Augusta Wood Cabin
Augusta
9.6 out of 10, Exceptional, (8 reviews)
"Nice log cabin home, good location, comfy king size bed. "
United States
Sherri S.
The price is AED 595
AED 1,354 total
includes taxes & fees
21 Jul - 22 Jul
Rustic Augusta Wood Cabin
Interior

Beekeeper's Cottage - Hot Tub, Heated Pool, Dog-friendly, Downtown

Beekeeper's Cottage - Hot Tub, Heated Pool, Dog-friendly, Downtown
Washington
9.8 out of 10, Exceptional, (25 reviews)
"Place is always reliably clean and comfortable. Love staying at this house."
United States
Sean C.
The price is AED 1,999
AED 2,458 total
includes taxes & fees
22 Jul - 23 Jul
Beekeeper's Cottage - Hot Tub, Heated Pool, Dog-friendly, Downtown
Smart TV, stereo

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, Exceptional, (80 reviews)
"Great location and beautiful place. Had a wonderful time. "
United States
Ernest R.
The price is AED 441
AED 923 total
includes taxes & fees
21 Jul - 22 Jul
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Defiance Hotel Reviews

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

10/10 Excellent
"Loved it. Love a place with nostalgia and it’s right off the highway. Big place. We got a bit lost trying to find the room but we will stay again!! We didn’t get to try the restaurant for food or drinks. But we will next time It was super inviting!"
Vicki 1-night trip
Posted 5 hours ago
Hilton St. Louis Frontenac

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals where you'll be just 9.8 mi (15.8 km) from Six Flags St. Louis, providing a secluded option if you'd like a quiet spot to stay. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟: This vacation home rental outside of Defiance offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

How many vacation rentals will I find in Defiance?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.