Top Vacation Homes in Des Moines County in 2026

Des Moines County Vacation Homes
Iowa
United States of America
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Our top choices for Des Moines County vacation homes

A spacious room with large windows offering a view of a lake and trees. There are two gray armchairs and a dining table with chairs.

A dining area with a glass table and leather chairs, large windows with a view of a lake, and a brick fireplace.

A patio with two chairs and a table, overlooking a lake with a white fence and a tree.

A spacious living room with a leather sofa, two armchairs, and a coffee table. A large window offers a view of a lake and distant hills.

1. PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

Nauvoo

9.6 out of 10, Exceptional, (14 reviews)

9.6/10

Exceptional

(14 reviews)

"Can’t say enough about the stunning view of the Mississippi River from every part of the home! The home was extremely comfortable for the two of us. We really enjoyed our stay!"

Debbie L.

The price is AED 529

AED 529

AED 1,218 total

includes taxes & fees

25 Oct - 26 Oct

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

A view through a window with a tree displaying autumn foliage.

A wooden interior with a central staircase, two windows, and a ceiling light.

A modern kitchen with wooden cabinets, stainless steel appliances, a dishwasher, a stove, and a microwave.

A white house with a windmill, surrounded by trees and open fields.

2. Nauvoo Windmill Farmhouse 10-12 people

Nauvoo Windmill Farmhouse 10-12 people

Niota

10.0 out of 10, Exceptional, (21 reviews)

10/10

Exceptional

(21 reviews)

"Great stay very peaceful "

larry r.

The price is AED 459

AED 459

AED 825 total

includes taxes & fees

22 Oct - 23 Oct

Nauvoo Windmill Farmhouse 10-12 people

A single-story house with a front porch, a sliding glass door, and a small deck area.

A wooden-built fireplace with a stone wall backdrop, a bookshelf filled with books and figurines, and a framed picture above the fireplace.

A living room with two brown sofas, a wooden coffee table, and a patterned ottoman. There is a piano and a framed picture on the wall.

A staircase with wooden balusters and a handrail, leading to a landing with a framed certificate or document.

3. Historic 1840s Lamoreaux House / Modern Addition

Historic 1840s Lamoreaux House / Modern Addition

Nauvoo

9.6 out of 10, Exceptional, (27 reviews)

9.6/10

Exceptional

(27 reviews)

"Plenty of space for our family. Good location."

Chelsea S.

The price is AED 909

AED 909

AED 1,325 total

includes taxes & fees

15 Oct - 16 Oct

Historic 1840s Lamoreaux House / Modern Addition

A wooden staircase with a white vase of flowers on a small table at the bottom.

A front-loading LG steam cycle washing machine with a control panel, located in a kitchen with a window above it.

A two-story house with a gabled roof, a front porch, and a snow-covered lawn.

A brown leather sofa with two orange cushions, a wooden coffee table, and six framed pictures on the wall.

4. Charming Cottage, close to all the sights.

Charming Cottage, close to all the sights.

Nauvoo

9.6 out of 10, Exceptional, (34 reviews)

9.6/10

Exceptional

(34 reviews)

"Good place for a family"

SANTIAGO

Charming Cottage, close to all the sights.

A wooden dock extending into calm water with trees reflecting on the surface, surrounded by a grassy area.

A two-story house with a front porch, a small deck, and a large tree with white blossoms.

A kitchen with wooden cabinets, a microwave, a sink, and a dining area with a glass table and chairs.

A kitchen with a built-in microwave, a dining area with a glass table and chairs, and large sliding glass doors leading to a deck with a view of trees and a body of water.

5. Riverside Waterfront on the Mississippi River

Riverside Waterfront on the Mississippi River

Pontoosuc

9.8 out of 10, Exceptional, (27 reviews)

9.8/10

Exceptional

(27 reviews)

"Great place good location "

willmer m.

The price is AED 562

AED 562

AED 1,125 total

includes taxes & fees

28 Oct - 29 Oct

Riverside Waterfront on the Mississippi River

A house with a fire pit in the backyard, a porch, and a blue chair.

A bedroom with a wooden bed, a nightstand, a desk, a lamp, and a window with curtains.

A compact kitchen with grey cabinets, a refrigerator, a microwave, and a window with curtains.

A wooden dining table with a chessboard, a framed plant, and a small box on the table.

6. Cozy House

Cozy House

Biggsville

10.0 out of 10, Exceptional, (8 reviews)

10/10

Exceptional

(8 reviews)

"Great place for our needs!"

jdl j.

The price is AED 314

AED 314

AED 644 total

includes taxes & fees

15 Oct - 16 Oct

Cozy House

A kitchen with a granite countertop, three bar stools, a yellow placemat, and a potted plant.

A bedroom with a bed, a ceiling fan, a window with curtains, and a painting on the wall.

A living room with a grey sofa, a blue armchair, a wooden floor, a ceiling fan, and a painting on the wall.

A wooden deck with a yellow Adirondack chair, a small table, and a grill.

7. Home Away From Home

Home Away From Home

Biggsville

10.0 out of 10, Exceptional, (3 reviews)

10/10

Exceptional

(3 reviews)

"Our stay was exceptional, couldn't have asked for a better home for out 4 day stay. Everything was so clean and roomy. Great kitchen area and 2 living rooms with a very nice TV 📺. I will be rebooking again in the future. The host was most helpful and kind."

Kathy

The price is AED 375

AED 375

AED 736 total

includes taxes & fees

18 Oct - 19 Oct

Home Away From Home

A living room with a sectional sofa, a coffee table, a TV mounted on the wall, and a wooden floor.

A bedroom with a wooden bed frame, white pillows, a dark bedspread, a window with a view of trees, and a wall-mounted decorative piece.

A room with a wicker chair, a glass-top table, and a patterned rug.

A modern kitchen with white cabinets, a black refrigerator, a microwave, an oven, and a sink.

8. Farmhouse Fantasy

Farmhouse Fantasy

Nauvoo

10.0 out of 10, Exceptional, (1 review)

10/10

Exceptional

(1 review)

Farmhouse Fantasy

A living room with two dark blue sofas, a white coffee table, and a small white side table. There is a framed map on the wall and a lamp on the side table.

A bathroom with a white sink, a toilet, a shower with frosted glass doors, and a mirror above the sink.

A room with a dark blue door, a white bench, a small table with a remote control, and a window with blinds.

A modern kitchen with a microwave, oven, and coffee maker. There is a window with blinds, a wooden dining table, and a chair.

9. Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Blandinsville

8.8 out of 10, Excellent, (19 reviews)

8.8/10

Excellent

(19 reviews)

"We loved how clean the house was. It was good for staying at for commencement at WIU. Mattresses were comfortable. Shower was nice. Very nice place to stay."

Annie

The price is AED 496

AED 496

AED 705 total

includes taxes & fees

27 Oct - 28 Oct

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

A rustic brick interior with a fireplace, a wooden stool, and a checkered rug.

A staircase leading to a landing with a wooden chair and a decorative pillow.

A dining table with a tray of pinecones.

A rustic room with exposed brick walls, a wooden floor, a fireplace, a window with a curtain, and a wooden chair.

10. Experience Beautiful Pioneer Home In Nauvoo!

Experience Beautiful Pioneer Home In Nauvoo!

Nauvoo

9.8 out of 10, Exceptional, (90 reviews)

9.8/10

Exceptional

(90 reviews)

"We had a great stay!"

Darin B.

The price is AED 698

AED 698

AED 1,394 total

includes taxes & fees

27 Oct - 28 Oct

Experience Beautiful Pioneer Home In Nauvoo!

A room with a wooden floor, a fireplace with a mantel, a door with glass panels, and a framed painting on the wall.

A kitchen with wooden cabinets, a white countertop, a dishwasher, and two rugs.

A living room with a sofa, armchairs, a patterned rug, and a stained glass window.

A grand staircase with ornate railings, a wooden table with a vase, and a patterned rug in a spacious room with wooden flooring and classic decor.

11. Grand Victorian on the Mississippi

Grand Victorian on the Mississippi

Fort Madison

9.8 out of 10, Exceptional, (33 reviews)

9.8/10

Exceptional

(33 reviews)

"Really fun house, with antiques and a lovely ambiance!"

Lauren O.

The price is AED 713

AED 713

AED 1,596 total

includes taxes & fees

19 Oct - 20 Oct

Grand Victorian on the Mississippi

A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a dining area with a TV.

A spacious dining area with a wooden table and chairs, a leather sofa, and a television mounted on the wall.

A wooden cabinet with multiple shelves, some holding plates and bowls, and others with jars and a coffee maker.

A two-car garage with a gravel driveway and a wooden fence.

12. Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

Montrose

10.0 out of 10, Exceptional, (21 reviews)

10/10

Exceptional

(21 reviews)

"Everything was fine."

Hans

Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

A room with a treadmill and an exercise bike, large windows with a view of a lake and houses, and a wall clock.

A balcony with a metal railing, a brick pillar, and a view of a lake and green landscape.

A modern kitchen with dark cabinets, stainless steel appliances, a white marble floor, and a red kettle.

13. Nauvoo River View 6 Bedrooms 5.5 bath Theater Arcade

Nauvoo River View 6 Bedrooms 5.5 bath Theater Arcade

Sonora Township

2.0 out of 10, (1 review)

2.0/10

(1 review)

"This is a beautiful property.But the details of the property are misleading such as the bathrooms.Also the property was very dirty beds not made with clean sheets dust on window sills, carpet not clean you could see where it was vacuumed but only in high traffic areas Also the property had a terrible sewer smell"

LuAnn S.

Nauvoo River View 6 Bedrooms 5.5 bath Theater Arcade

A compact bathroom with a washing machine, a towel rack, a shelf with a plant, and a shower curtain.

A modern kitchen with wooden cabinets, stainless steel appliances, a granite countertop, and a dining area with a wooden table and chairs.

A bunk bed with three levels, a round wall clock, a small table with a picture, and a plaid rug.

A modern living room with a dining area, grey walls, a flat-screen TV, and a grey sofa.

14. If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

Media

10.0 out of 10, Exceptional, (2 reviews)

10/10

Exceptional

(2 reviews)

"Nice little place out in the country. Great place for a getaway!"

Judy W.

The price is AED 367

AED 367

AED 584 total

includes taxes & fees

15 Oct - 16 Oct

If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

A living room with a sofa, coffee table, TV, and a ceiling fan.

A kitchen with white cabinets, a toaster, a kettle, and a sink.

A living room with a yellow armchair, a blue ottoman, and a potted plant near a large window with patterned curtains.

A single-story house with a dark blue front door, a small porch, and a window with a curtain.

15. Charming Modern 1950s Mid-Century Ranch.

Charming Modern 1950s Mid-Century Ranch.

Mount Pleasant

9.8 out of 10, Exceptional, (18 reviews)

9.8/10

Exceptional

(18 reviews)

"We truly enjoyed our stay! We travel to Iowa quite a bit and this place is a gem. It allows us to have space to chill out yet is close to so many of our friends and family."

Holly S.

Charming Modern 1950s Mid-Century Ranch.

A room with a brick fireplace, a television on a stand, and an open book with glasses on it.

A living room with a grey armchair, a sofa with red cushions, a patterned rug, and a clock on the wall.

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a glass dining table with four chairs.

A two-story brick building with a white door and shutters, a number "1690" sign, and a small porch area.

16. Historic Gem 1840's newly furnished brick house.

Historic Gem 1840's newly furnished brick house.

Nauvoo

10.0 out of 10, Exceptional, (88 reviews)

10/10

Exceptional

(88 reviews)

"Fantastic home located very close to everything you want to do in Nabu! The AC worked great and it is conveniently located to grab some quick supplies. Great hosts and easy check-in/check-out!"

Greg N.

Historic Gem 1840's newly furnished brick house.

A wooden deck with a bench, a small shed, and a yellow building in a grassy area with trees and a body of water in the background.

A dining area with a wooden table and chairs, a potted plant, and a view of a living room with a sofa and a lamp.

A room with two yellow chairs in front of a window, a small wooden table, and a white chair.

A kitchen with two sinks, white cabinets, and a countertop.

17. Oquawka Cottage With River View

Oquawka Cottage With River View

Oquawka

9.6 out of 10, Exceptional, (9 reviews)

9.6/10

Exceptional

(9 reviews)

"Cute little cottage, very clean. Wonderful beds. Very peaceful visit. Will come again"

sally

Oquawka Cottage With River View

A spacious living area with a wooden staircase, a large window, and a patterned wall.

A living room with a brown sofa, a coffee table, and a television. There are framed pictures on the wall and a staircase in the background.

A bookshelf with books, a potted plant, and decorative items.

A room with a dark blue sofa, two yellow cushions, a round wooden table with metal legs, and a patterned rug.

18. Charming 4 bedroom home near Downtown.

Charming 4 bedroom home near Downtown.

Burlington

10.0 out of 10, Exceptional, (5 reviews)

10/10

Exceptional

(5 reviews)

"We absolutely loved everything about the house"

Jean W.

Charming 4 bedroom home near Downtown.

A house with a porch and a garden with red roses.

A two-story house with a front porch, two chairs, and a mailbox.

A dining room with a wooden table and four chairs, a potted plant, a white cabinet, and a framed wreath on the wall.

A living room with a grey sofa, a brown ottoman, a television, and a bookshelf with decorative items.

19. Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

Nauvoo

10.0 out of 10, Exceptional, (38 reviews)

10/10

Exceptional

(38 reviews)

"We loved the ping-pong table and the arcade games. The house was super clean, comfortable and accommodating. Highly recommend this darling vintage home."

Joan K.

Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

A compact kitchen with a dining area, a sofa, and a window with blinds.

A narrow hallway with a wooden floor, white walls, and a ceiling light fixture.

A bedroom with a bed, two windows, and a ceiling light fixture.

A two-story brick building with a white facade, a balcony on the second floor, and a covered entrance with a sign that reads "COMMERCE HOUSE."

20. Downtown Columbus 2 bedroom unit with great views!

Downtown Columbus 2 bedroom unit with great views!

Columbus Junction

6.0 out of 10, (3 reviews)

6.0/10

(3 reviews)

"Clean and comfortable. Host communicated well. Nothing to complain about. Would stay here again."

Geoff G.

Downtown Columbus 2 bedroom unit with great views!

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Des Moines County Hotel Reviews

AmericInn by Wyndham Mount Pleasant

10/10 Excellent

"Easy check in, nice clean rooms."

Margaret 1-night trip

Posted 10 hours ago

AmericInn by Wyndham Mount Pleasant

Holiday Inn Express Hotel & Suites Burlington by IHG

10/10 Excellent

"Friendly staff, working hot tub, very clean"

Samantha 1-night trip

Posted 17 hours ago

Holiday Inn Express Hotel & Suites Burlington by IHG

AmericInn by Wyndham West Burlington

10/10 Excellent

"Clean room, nice employees"

Nick 2-night trip

Posted 1 day ago

AmericInn by Wyndham West Burlington

Quality Inn & Suites Mount Pleasant

10/10 Excellent

"It was a surprise to find out after already making meal plates that one cannot take breakfast out of the dining room, even if one's spouse drove into the early AM hours and would have slept right thru breakfast.... Jacuzzi tub was nice. Beds were a bit on the hard side but otherwise the room was good. Clean and kwpt.up for the most part. A door might not shut all the way or the security jasp might not have worked, but the room was well, priced for the value."

Christopher 3-night trip

Posted 2 days ago

Quality Inn & Suites Mount Pleasant

The Inn at Old Nauvoo

10/10 Excellent

"We loved our clean, safe and comfortable stay."

Hollie 2-night trip

Posted 2 days ago

The Inn at Old Nauvoo

Evans Holly Grove Inn B&B

10/10 Excellent

"Right in the middle of a wonderful historic area, makes for a nice walk in the neighborhood. Home is beautiful."

Jim 1-night trip

Posted 2 days ago

Evans Holly Grove Inn B&B

Nauvoo Temple House Hotel

10/10 Excellent

"Just what we needed. Clean and quiet room close to our activities. Friendly and helpful staff."

Dave 1-night trip

Posted 3 days ago

Nauvoo Temple House Hotel

Best Western Mt. Pleasant Inn

8/10 Good

"We enjoyed our stay. Only complaint was that the room smelled musty. Thank you"

Jeffrey 2-night trip

Posted 5 days ago

Best Western Mt. Pleasant Inn

Hampton Inn & Suites Burlington

10/10 Excellent

"No complaints with hotel, casino on the other hand…😂"

Michael 5-night trip

Posted 10 days ago

Hampton Inn & Suites Burlington

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Vacation Homes in Des Moines County

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Des Moines County vacation homes

1. PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

2. Nauvoo Windmill Farmhouse 10-12 people

3. Historic 1840s Lamoreaux House / Modern Addition

4. Charming Cottage, close to all the sights.

5. Riverside Waterfront on the Mississippi River

6. Cozy House

7. Home Away From Home

8. Farmhouse Fantasy

9. Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

10. Experience Beautiful Pioneer Home In Nauvoo!

11. Grand Victorian on the Mississippi

12. Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

13. Nauvoo River View 6 Bedrooms 5.5 bath Theater Arcade

14. If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

15. Charming Modern 1950s Mid-Century Ranch.

16. Historic Gem 1840's newly furnished brick house.

17. Oquawka Cottage With River View

18. Charming 4 bedroom home near Downtown.

19. Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

20. Downtown Columbus 2 bedroom unit with great views!

Find vacation rentals that suit your style

Top Des Moines County Hotel Reviews

AmericInn by Wyndham Mount Pleasant

Explore a world of travel with Expedia