Find & Book the Best Hotels in Darlington County for 2026

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Darlington County hotels

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

1. Park Inn by Radisson Florence, SC

Florence

Susan

AED 371 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a reception desk, seating area, and a television screen.

2. Comfort Inn & Suites Florence Center Area

Florence

Steven

AED 416 total

includes taxes & fees

29 Nov - 30 Nov

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

3. Spark by Hilton Florence North I-95, SC

Florence

Alanya

AED 420 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

4. Howard Johnson by Wyndham Florence

Florence

Carl

AED 250 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a wooden headboard, a nightstand, and three sunset paintings on the wall.

5. Days Inn by Wyndham Florence Near Civic Center

Florence

Louis

AED 272 total

includes taxes & fees

2 Dec - 3 Dec

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

6. Hyatt Place Florence Downtown

Florence

Ana Maria

AED 478 total

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a desk, a bed, a sofa, a TV, and a mirror.

7. Quality Inn & Suites Florence Civic Center

Florence

Sharhonda

AED 367 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

8. Hampton Inn & Suites Florence Center

Florence

NOORUDIN

AED 469 total

includes taxes & fees

15 Nov - 16 Nov

A multi-story hotel with a prominent entrance and signage for Springhill Suites by Marriott.

9. SpringHill Suites by Marriott Florence

Florence

Tom

AED 444 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

10. TownePlace Suites by Marriott Florence

Florence

Ralph

AED 451 total

includes taxes & fees

8 Nov - 9 Nov

A hotel entrance with a covered walkway, columns, and a number '340' sign.

11. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Florence

Leigh

AED 469 total

includes taxes & fees

22 Nov - 23 Nov

A hotel entrance with a covered walkway, a brick pathway, and a well-maintained garden.

12. Staybridge Suites Florence - Civic Center by IHG

Florence

Tishia

AED 539 total

includes taxes & fees

6 Dec - 7 Dec

An outdoor seating area with a fire pit, cushioned seating, and a pergola with string lights.

13. Tru by Hilton Florence I-95

Florence

Margarita

AED 473 total

includes taxes & fees

12 Nov - 13 Nov

A restaurant with brick walls, framed awards, and a bar area.

14. Hotel Florence, Tapestry Collection by Hilton

Florence

WILLIE

AED 570 total

includes taxes & fees

15 Nov - 16 Nov

A modern lobby with seating areas, a reception desk, and a large wall with a decorative panel.

15. Comfort Suites Florence I-95

Florence

Michael

AED 488 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a high ceiling, a central seating area, and a staircase leading to an upper level.

16. La Quinta Inn & Suites by Wyndham Florence

Florence

Brenda

AED 374 total

includes taxes & fees

9 Nov - 10 Nov

A spacious room with a large window, a kitchenette, and two chairs.

17. Florence Inn and Suites

Florence

Latonya

AED 206 total

includes taxes & fees

7 Dec - 8 Dec

A spacious hotel lobby with multiple seating areas, including tables and chairs, a reception desk, and a staircase leading to an upper level.

18. Hampton Inn & Suites Florence-North-I-95

Florence

chantal

AED 469 total

includes taxes & fees

12 Nov - 13 Nov

A modern living room with a sectional sofa, a coffee table, and a flat-screen TV mounted on the wall.

19. Super 8 by Wyndham Florence

Florence

Shawn

AED 220 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, bedside table with a phone, a desk with a chair, a TV mounted on the wall, and a window with curtains.

20. Microtel Inn & Suites by Wyndham Florence

Florence

SINDAYIGAYA

AED 251 total

includes taxes & fees

30 Nov - 1 Dec

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Top Darlington County Hotel Reviews

Park Inn by Radisson Florence, SC

10/10 Excellent

"Convenient to I-95"

Spark by Hilton Florence North I-95, SC

8/10 Good

"Checking in was a breeze. Andrea was awesome. Room nicely decorated, spacious and very clean. However the breakfast area was not. Counters were not wiped off. When I approached the staff to let them know they were out of coffee, I witnessed him filling the tray of bagels WITHOUT GLOVES."

TownePlace Suites by Marriott Florence

10/10 Excellent

"My stay was awesome! The entire staff was friendly and extremely helpful on all the small things that can make travel stressful. From the moment I walked in they provided gold star service. Jenine, Kamesha (sp?), Hanna, and the rest of the staff were spectacular. I opening the spellings correct, my apologies if I did not. I would absolutely (and likely) stay again!"

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Darlington County hotels

1. Park Inn by Radisson Florence, SC

2. Comfort Inn & Suites Florence Center Area

3. Spark by Hilton Florence North I-95, SC

4. Howard Johnson by Wyndham Florence

5. Days Inn by Wyndham Florence Near Civic Center

6. Hyatt Place Florence Downtown

7. Quality Inn & Suites Florence Civic Center

8. Hampton Inn & Suites Florence Center

9. SpringHill Suites by Marriott Florence

10. TownePlace Suites by Marriott Florence

11. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

12. Staybridge Suites Florence - Civic Center by IHG

13. Tru by Hilton Florence I-95

14. Hotel Florence, Tapestry Collection by Hilton

15. Comfort Suites Florence I-95

16. La Quinta Inn & Suites by Wyndham Florence

17. Florence Inn and Suites

18. Hampton Inn & Suites Florence-North-I-95

19. Super 8 by Wyndham Florence

20. Microtel Inn & Suites by Wyndham Florence

Top Darlington County Hotel Reviews

Park Inn by Radisson Florence, SC

Spark by Hilton Florence North I-95, SC

Hyatt Place Florence Downtown

SpringHill Suites by Marriott Florence

TownePlace Suites by Marriott Florence

1912 Bed and Breakfast

Explore a world of travel with Expedia

Go further with the Expedia app

Search Hotels in Darlington County

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Darlington County hotels

1. Park Inn by Radisson Florence, SC

2. Comfort Inn & Suites Florence Center Area

3. Spark by Hilton Florence North I-95, SC

4. Howard Johnson by Wyndham Florence

5. Days Inn by Wyndham Florence Near Civic Center

6. Hyatt Place Florence Downtown

7. Quality Inn & Suites Florence Civic Center

8. Hampton Inn & Suites Florence Center

9. SpringHill Suites by Marriott Florence

10. TownePlace Suites by Marriott Florence

11. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

12. Staybridge Suites Florence - Civic Center by IHG

13. Tru by Hilton Florence I-95

14. Hotel Florence, Tapestry Collection by Hilton

15. Comfort Suites Florence I-95

16. La Quinta Inn & Suites by Wyndham Florence

17. Florence Inn and Suites

18. Hampton Inn & Suites Florence-North-I-95

19. Super 8 by Wyndham Florence

20. Microtel Inn & Suites by Wyndham Florence

Top Darlington County Hotel Reviews

Park Inn by Radisson Florence, SC

Explore a world of travel with Expedia

Go further with the Expedia app