East Prairie, MO

Travel Guide

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is AED 331 per night from Dec 29 to Dec 30
AED 331
AED 380 total
29 Dec - 30 Dec
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,004 reviews)
Everything was well done

Reviewed on 18 December 2025

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
The price is AED 358 per night from Jan 4 to Jan 5
AED 358
AED 406 total
4 Jan - 5 January 2026
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (449 reviews)
Everything we just lovely

Reviewed on 20 December 2025

Hampton Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is AED 278 per night from Dec 29 to Dec 30
AED 278
AED 317 total
29 Dec - 30 Dec
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,003 reviews)
Great stay, everything was clean and comfortable.

Reviewed on 20 December 2025

Best Western Plus Sikeston
See all 85 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters

3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters

2 out of 5
Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy laundry facilities. Popular attractions Willow Towhead and Rat Island are located nearby.
The house was exaclty what we needed. It had everything we needed. We will be back. Great set up for a large group.

Reviewed on 7 December 2025

3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters
Log Cabin.

Log Cabin.

Hornbeak TN
Stay at this cabin in Hornbeak. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Lake Isom National Wildlife Refuge and Willow Towhead are ...
9/10 Wonderful! (32 reviews)
The cabin is beautiful! Had no issues at all. Slept all 14 of us easily and could have slept more. The pond was the kids favorite, loved fishing out of it.

Reviewed on 2 September 2025

Log Cabin.
Come and relax at the Refuge at beautiful Reelfoot Lake!

Come and relax at the Refuge at beautiful Reelfoot Lake!

Hornbeak TN
Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located nearby.
9.2/10 Wonderful! (23 reviews)
Great place

Reviewed on 11 December 2025

Come and relax at the Refuge at beautiful Reelfoot Lake!
See all properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Big Oak Tree State Park

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

Big Oak Tree State Park