A panoramic view of a historic city with a river, prominent domed buildings, and a bridge.

Florence Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Florence vacation rentals

Charming 2-bedroom apartment MINUTES from Darlington Raceway with pond views

Charming 2-bedroom apartment MINUTES from Darlington Raceway with pond views
Hartsville
10.0 out of 10, Exceptional, (12 reviews)
"Very clean, stayed here for work. Would definitely book again if in the area. "
United States
Kacey
The price is AED 294
AED 601 total
includes taxes & fees
9 Jul - 10 Jul
Charming 2-bedroom apartment MINUTES from Darlington Raceway with pond views

Charming Cottage with easy access to local attractions-pet and kid friendly

Charming Cottage with easy access to local attractions-pet and kid friendly
Sellers
9.6 out of 10, Exceptional, (28 reviews)
"A great place to stay with our two dogs. We will be back again soon."
United States
Marianne P.
The price is AED 347
AED 723 total
includes taxes & fees
1 Jul - 2 Jul
Charming Cottage with easy access to local attractions-pet and kid friendly

imperial motel

imperial motel
Mullins
The price is AED 253
AED 388 total
includes taxes & fees
6 Jul - 7 Jul
imperial motel

In 1840 Burn Cottage

In 1840 Burn Cottage
Society Hill
9.6 out of 10, Exceptional, (35 reviews)
"Nice historic house provided authentic late-1800s three night stay. Enjoyed our stay."
United States
Ansel C.
The price is AED 397
AED 753 total
includes taxes & fees
1 Jul - 2 Jul
In 1840 Burn Cottage

Peaceful Farm Getaway

Peaceful Farm Getaway
Mullins
10.0 out of 10, Exceptional, (36 reviews)
"Awesome location near family for the holiday. I can’t wait to book again "
United States
sheliars1 ..
The price is AED 496
AED 773 total
includes taxes & fees
30 Jun - 1 Jul
Peaceful Farm Getaway

Lakeside 2-bedroom RV in charming Hartsville with AC, WiFi

Lakeside 2-bedroom RV in charming Hartsville with AC, WiFi
Hartsville
8.0 out of 10, Very Good, (1 review)
"The stay was fine , with no problems."
United States
Mark H.
The price is AED 275
AED 581 total
includes taxes & fees
12 Jul - 13 Jul
Lakeside 2-bedroom RV in charming Hartsville with AC, WiFi

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.
Florence
9.8 out of 10, Exceptional, (53 reviews)
"Our third time staying at this home and always have had a great experience. Such a comfy home and very well stocked. Great hosts!"
United States
Kelly W.
Walking distance from one of South Carolina's top Medical centers.

Beautiful 1-bedroom apartment perfect for traveling professionals.

Beautiful 1-bedroom apartment perfect for traveling professionals.
Bishopville
The price is AED 380
AED 508 total
includes taxes & fees
5 Jul - 6 Jul
Beautiful 1-bedroom apartment perfect for traveling professionals.

The Pinecone Retreat - Only 1 mile from i95

The Pinecone Retreat - Only 1 mile from i95
Latta
10.0 out of 10, Exceptional, (2 reviews)
"So comfy and cozy but plenty of room for our family of four!"
United States
Nita S.
The price is AED 441
AED 561 total
includes taxes & fees
29 Jun - 30 Jun
The Pinecone Retreat - Only 1 mile from i95

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Florence
8.6 out of 10, Excellent, (4 reviews)
"Convenient location"
United States
Bonney W.
The price is AED 621
AED 1,958 total
includes taxes & fees
5 Jul - 6 Jul
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Secret SC Cabin on 100 acres Hot Tub Large Pond

Secret SC Cabin on 100 acres Hot Tub Large Pond
Marion
9.6 out of 10, Exceptional, (184 reviews)
"Very Private Beautiful spiral staircase Great big Hot tub out in the moonlight!"
United States
Elissa M.
The price is AED 744
AED 1,728 total
includes taxes & fees
30 Jun - 1 Jul
Secret SC Cabin on 100 acres Hot Tub Large Pond

Wonderful 2-bedroom house charming ranch style home

Wonderful 2-bedroom house charming ranch style home
Florence
The price is AED 479
AED 619 total
includes taxes & fees
1 Jul - 2 Jul
Wonderful 2-bedroom house charming ranch style home

Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence!

Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence!
Marion
9.0 out of 10, Wonderful, (6 reviews)
"It was a great place. "
United States
Cindy N.
The price is AED 735
AED 2,198 total
includes taxes & fees
30 Jun - 1 Jul
Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence!

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Florence
10.0 out of 10, Exceptional, (56 reviews)
"Great place, always clean and a top notch stay!"
United States
K H.
The price is AED 820
AED 1,050 total
includes taxes & fees
29 Jun - 30 Jun
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Perfect Stop • Near I-95, Downtown & Civic Center and Darlington

Perfect Stop • Near I-95, Downtown & Civic Center and Darlington
Florence
10.0 out of 10, Exceptional, (11 reviews)
"We had a wonderful stay. We plan to take a trip around the same time next year and will definitely see if this home is available! "
United States
Taryn S.
The price is AED 820
AED 1,050 total
includes taxes & fees
29 Jun - 30 Jun
Perfect Stop • Near I-95, Downtown & Civic Center and Darlington

The Perfect Home Base to Explore The Carolinas, See Family, or Find Quiet

The Perfect Home Base to Explore The Carolinas, See Family, or Find Quiet
Bennettsville
9.8 out of 10, Exceptional, (30 reviews)
"Far from the Madding Crowd, this farm property is hidden in a field surrounded by trees. Very quiet."
United States
Anand
The price is AED 179
AED 290 total
includes taxes & fees
29 Jun - 30 Jun
The Perfect Home Base to Explore The Carolinas, See Family, or Find Quiet

Camden Cottage

Camden Cottage
Camden
10.0 out of 10, Exceptional, (64 reviews)
The price is AED 364
AED 654 total
includes taxes & fees
6 Jul - 7 Jul
Camden Cottage

Charming 2-bedroom house with AC, WiFi in the heart of Pembroke

Charming 2-bedroom house with AC, WiFi in the heart of Pembroke
Pembroke
9.8 out of 10, Exceptional, (6 reviews)
"Great location and so much better then staying in a hotel!"
United States
Teresa G.
The price is AED 551
AED 1,415 total
includes taxes & fees
5 Jul - 6 Jul
Charming 2-bedroom house with AC, WiFi in the heart of Pembroke

Queen Bed Non-Smoking

Queen Bed Non-Smoking
Chesterfield, SC
The price is AED 381
AED 450 total
includes taxes & fees
29 Jun - 30 Jun
Queen Bed Non-Smoking

Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.

Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.
Camden
10.0 out of 10, Exceptional, (11 reviews)
"Great location and property!!! Thanks for everything!!!"
United States
Alessandra H.
The price is AED 364
AED 551 total
includes taxes & fees
5 Jul - 6 Jul
Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Florence Hotel Reviews

Frequently asked questions

Can I find vacation rentals in Florence?

Yes, we have vacation rentals in Florence close to Eastern Carolina Agricultural Fairgrounds, or you can choose a secluded option if you'd like a relaxing place to stay. Tourists like the array of shops and top-notch restaurants in Florence. You can also check out the entertainment venues while you're visiting.

What are some of the best vacation rentals in Florence?

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.: Visitors give good reviews to this Florence vacation home rental, which has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Our travelers also rate Walking distance from one of South Carolina's top Medical centers. as a favorite home for rent in Florence.

How many vacation rentals will I find in Florence?

Choose from 37 Expedia vacation rentals in Florence for a memorable vacation.

What can I see and do in Florence?

Palmetto Shores Lake and Florence Veterans Park are a couple of scenic spots to enjoy the outdoors, whereas Florence Museum is one of the cultural attractions. Other places in town to visit include Magnolia Mall and Florence Civic Center.

What are vacation rentals like in Florence?

Vacation rentals are privately owned accommodations you can reserve for a couple days or more in Florence. Vacation rentals offer extras such as hot tubs, fire pits, and patios so you'll have a home away from home. If you're concerned about cleanliness, a vacation rental can provide a sense of privacy away from public hotel elevators and busy concierge desks while still allowing you to travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a popular choice for a family trip or a small group gathering.