Find Adults Only Resorts & Hotels in Florida Keys

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys Adults Only Resorts & Hotels

Our top choices for Florida Keys adults-only hotels

Duval House

Duval House
3.0 star property
Old Town Key West
9.4 out of 10, Exceptional, (1,046 reviews)
"Great location and clean rooms. Breakfast staff is so sweet! Will stay here again for sure!!"
United States
Wendy S
The price is AED 393
AED 522 total
includes taxes & fees
17 Jun - 18 Jun
Duval House

Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
4.0 star property
Old Town Key West
9.4 out of 10, Exceptional, (1,002 reviews)
"Fresh continental breakfast, clean room, close to everything."
United States
BOBBY J.
The price is AED 585
AED 1,123 total
includes taxes & fees
30 Jun - 1 Jul
Southernmost House - Adult Exclusive

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West
9.6 out of 10, Exceptional, (1,007 reviews)
"we had a great stay, rented bikes"
United States
Duncan
The price is AED 474
AED 625 total
includes taxes & fees
17 Jun - 18 Jun
The Grand Guesthouse

Tropical Inn

Tropical Inn
3.5 star property
Old Town Key West
9.6 out of 10, Exceptional, (410 reviews)
"Very friendly staff and a prime location."
United States
Akhenaton
The price is AED 581
AED 745 total
includes taxes & fees
17 Jun - 18 Jun
Tropical Inn

The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only
3.0 star property
Old Town Key West
9.0 out of 10, Wonderful, (1,013 reviews)
"Great place"
United States
Andrea
The price is AED 488
AED 714 total
includes taxes & fees
17 Jun - 18 Jun
The Cabana Inn Key West - Adults Only

The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only
3.0 star property
Old Town Key West
8.4 out of 10, Very Good, (1,396 reviews)
"Lovely hotel very comfortable room. Great pool facilities. Helpful staff. Would recommend this hotel."
Australia
Sharon
The price is AED 449
AED 670 total
includes taxes & fees
17 Jun - 18 Jun
The Southernmost Inn - Adults Only

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Key West Historic District
9.4 out of 10, Exceptional, (994 reviews)
"Loved the location, breakfast and clean room. Staff, Drew, very friendly and helpful. Will definitely stay here again."
United States
Richard
The price is AED 437
AED 492 total
includes taxes & fees
18 Jun - 19 Jun
L'Habitation Guest House

Heron House Court - Adult Only

Heron House Court - Adult Only
3.0 star property
Key West Historic District
9.0 out of 10, Wonderful, (1,012 reviews)
"Everything was wonderful!!"
United States
Iris
The price is AED 526
AED 717 total
includes taxes & fees
17 Jun - 18 Jun
Heron House Court - Adult Only

Coco Plum Inn

Coco Plum Inn
3.0 star property
Old Town Key West
9.4 out of 10, Exceptional, (536 reviews)
"Loved the property and staff was super friendly."
United States
Brinkley
The price is AED 659
AED 742 total
includes taxes & fees
13 Jul - 14 Jul
Coco Plum Inn

NYAH Key West - Adults Only

NYAH Key West - Adults Only
3.0 star property
Key West Historic District
8.2 out of 10, Very Good, (1,027 reviews)
"Nice place to stay!"
United States
michael
The price is AED 295
AED 497 total
includes taxes & fees
17 Jun - 18 Jun
NYAH Key West - Adults Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Florida Keys

Discover top Florida Keys attractions

The Florida Keys offer an exceptional blend of adventure and relaxation, perfect for families seeking quality experiences. Start your journey at John Pennekamp Coral Reef State Park in Key Largo, where you can snorkel or dive amidst vibrant coral reefs filled with marine life—perfect for the adventurous family. Next, visit the iconic Seven Mile Bridge, where breathtaking views of the turquoise waters await; it’s a fantastic spot for a family photo op. Don’t miss the opportunity to explore the charming streets of Key West, where you can visit the Ernest Hemingway Home and Museum, offering a glimpse into the life of the legendary author. For a unique experience, try a sunset sail with a local charter, allowing you to soak in the stunning sunset views while sipping on refreshing drinks. When it comes to accommodations, consider staying in the vibrant area of Islamorada, known as the Sport Fishing Capital of the World. Here, you’ll find a range of waterfront resorts with family-friendly amenities, ensuring a comfortable and pampered stay. With attentive service and easy access to both relaxation and adventure, your family will create unforgettable memories in this beautiful region.

Top Florida Keys Hotel Reviews

Explore a world of travel with Expedia