Find Adults Only Resorts & Hotels in Florida Keys

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys Adults Only Resorts & Hotels

Our top choices for Florida Keys adults-only hotels

Duval House

Duval House
3.0 star property
Old Town Key West
9.4 out of 10, Exceptional, (1,039 reviews)
"Great location and clean rooms. Breakfast staff is so sweet! Will stay here again for sure!!"
United States
Wendy S
The price is AED 393
AED 522 total
includes taxes & fees
14 Jun - 15 Jun
Duval House

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West
9.6 out of 10, Exceptional, (1,005 reviews)
"we had a great stay, rented bikes"
United States
Duncan
The price is AED 465
AED 615 total
includes taxes & fees
15 Jun - 16 Jun
The Grand Guesthouse

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Old Town Key West
9.6 out of 10, Exceptional, (419 reviews)
"Great stay"
United States
Matthew
The price is AED 457
AED 566 total
includes taxes & fees
15 Jun - 16 Jun
Douglas House - Adults Only

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Key West Historic District
9.4 out of 10, Exceptional, (989 reviews)
"Great property! Excellent location and Drew was great."
United States
Amy
The price is AED 493
AED 554 total
includes taxes & fees
15 Jun - 16 Jun
L'Habitation Guest House

Tropical Inn

Tropical Inn
3.5 star property
Old Town Key West
9.6 out of 10, Exceptional, (406 reviews)
"Very friendly staff and a prime location."
United States
Akhenaton
The price is AED 559
AED 721 total
includes taxes & fees
15 Jun - 16 Jun
Tropical Inn

Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
4.0 star property
Old Town Key West
9.4 out of 10, Exceptional, (1,001 reviews)
"Fresh continental breakfast, clean room, close to everything."
United States
BOBBY J.
The price is AED 702
AED 1,255 total
includes taxes & fees
24 Jun - 25 Jun
Southernmost House - Adult Exclusive

Bahia Bay Resort

Bahia Bay Resort
2.5 star property
Rock Harbor
9.0 out of 10, Wonderful, (176 reviews)
"Amazing stay! Im so happy we found this cute romantic little spot"
United States
Laura
The price is AED 538
AED 606 total
includes taxes & fees
14 Jun - 15 Jun
Bahia Bay Resort

The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only
3.0 star property
Old Town Key West
9.0 out of 10, Wonderful, (1,011 reviews)
"My new favorite place to stay in Key West."
United States
Nickolas
The price is AED 488
AED 714 total
includes taxes & fees
14 Jun - 15 Jun
The Cabana Inn Key West - Adults Only

The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only
3.0 star property
Old Town Key West
8.4 out of 10, Very Good, (1,386 reviews)
"Great location, nice breakfast and happy hour pool was great"
United States
Patrick
The price is AED 423
AED 641 total
includes taxes & fees
15 Jun - 16 Jun
The Southernmost Inn - Adults Only

Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
2.5 star property
Rock Harbor
9.8 out of 10, Exceptional, (326 reviews)
"What a wonderful stay we had at Kona Kai Resort. It is a true gem set amidst beautiful beachfront landscape that offers both tranquility and breathtaking scenery."
United States
Christine
The price is AED 625
AED 806 total
includes taxes & fees
14 Jun - 15 Jun
Kona Kai Resort and Gallery - Adults Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Florida Keys

Discover top Florida Keys attractions

The Florida Keys offer an exceptional blend of adventure and relaxation, perfect for families seeking quality experiences. Start your journey at John Pennekamp Coral Reef State Park in Key Largo, where you can snorkel or dive amidst vibrant coral reefs filled with marine life—perfect for the adventurous family. Next, visit the iconic Seven Mile Bridge, where breathtaking views of the turquoise waters await; it’s a fantastic spot for a family photo op. Don’t miss the opportunity to explore the charming streets of Key West, where you can visit the Ernest Hemingway Home and Museum, offering a glimpse into the life of the legendary author. For a unique experience, try a sunset sail with a local charter, allowing you to soak in the stunning sunset views while sipping on refreshing drinks. When it comes to accommodations, consider staying in the vibrant area of Islamorada, known as the Sport Fishing Capital of the World. Here, you’ll find a range of waterfront resorts with family-friendly amenities, ensuring a comfortable and pampered stay. With attentive service and easy access to both relaxation and adventure, your family will create unforgettable memories in this beautiful region.

Top Florida Keys Hotel Reviews

Explore a world of travel with Expedia