A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find Adults Only Resorts & Hotels in Florida Keys

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys Adults Only Resorts & Hotels

Our top choices for Florida Keys adults-only hotels

The National Hotel Miami Beach

The National Hotel Miami Beach
4.5 star property
South Beach
9.0 out of 10, Wonderful, (1,797 reviews)
"Great place to stay"
United States
kelsey
The price is AED 493
AED 792 total
includes taxes & fees
3 Aug - 4 Aug
The National Hotel Miami Beach

Hotel Greystone - Adults Only

Hotel Greystone - Adults Only
4.0 star property
South Beach
9.0 out of 10, Wonderful, (1,005 reviews)
"Nice hotel on a good location close to ocean drive."
Mexico
Enrique
The price is AED 480
AED 736 total
includes taxes & fees
2 Aug - 3 Aug
Hotel Greystone - Adults Only

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Old Town Key West
10.0 out of 10, Exceptional, (1,018 reviews)
"Great stay! Great location and friendly, helpful staff. Loved our stay here! Would recommend."
United States
Linda
The price is AED 764
AED 859 total
includes taxes & fees
15 Jul - 16 Jul
Almond Tree Inn Hotel - Adults Only

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Old Town Key West
9.6 out of 10, Exceptional, (447 reviews)
"Great stay"
United States
Matthew
The price is AED 429
AED 530 total
includes taxes & fees
20 Jul - 21 Jul
Douglas House - Adults Only

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West
9.8 out of 10, Exceptional, (1,003 reviews)
"Friendly and helpful staff, and the rooms were exceptionally clean and comfortable. Everything was well-maintained, and the overall experience was wonderful. I will definitely be coming back again!"
United States
Helia
The price is AED 830
AED 1,140 total
includes taxes & fees
2 Aug - 3 Aug
The Marquesa Hotel

Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
2.5 star property
Rock Harbor
9.8 out of 10, Exceptional, (332 reviews)
"Very relaxing and low key spot with lots of fun outdoor amenities, staff got us into our room early and were super helpful and friendly. Would stay here again."
United States
Michelle
The price is AED 764
AED 962 total
includes taxes & fees
3 Aug - 4 Aug
Kona Kai Resort and Gallery - Adults Only

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Old Town Key West
9.8 out of 10, Exceptional, (1,007 reviews)
"Wonderful place and staff!"
United States
William
The price is AED 704
AED 792 total
includes taxes & fees
15 Jul - 16 Jul
Orchid Key Inn - Adults Only

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West
9.6 out of 10, Exceptional, (1,005 reviews)
"We loved our one night stay here! Everything was very clean and the staff was very helpful in letting us do self check-in since we arrived after 5:30. The breakfast was perfect and I enjoyed the views in the courtyard."
United States
Elizabeth
The price is AED 442
AED 589 total
includes taxes & fees
15 Jul - 16 Jul
The Grand Guesthouse

Weatherstation Inn

Weatherstation Inn
2.5 star property
Old Town Key West
9.4 out of 10, Exceptional, (1,009 reviews)
"Quaint place to stay with access to there other more resort style property made for an amazing experience."
United States
Bret
The price is AED 657
AED 740 total
includes taxes & fees
14 Jul - 15 Jul
Weatherstation Inn

Bahia Bay Resort

Bahia Bay Resort
2.5 star property
Rock Harbor
9.0 out of 10, Wonderful, (182 reviews)
"Amazing stay! Im so happy we found this cute romantic little spot"
United States
Laura
The price is AED 493
AED 554 total
includes taxes & fees
21 Jul - 22 Jul
Bahia Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Florida Keys

Discover top Florida Keys attractions

The Florida Keys offer an exceptional blend of adventure and relaxation, perfect for families seeking quality experiences. Start your journey at John Pennekamp Coral Reef State Park in Key Largo, where you can snorkel or dive amidst vibrant coral reefs filled with marine life—perfect for the adventurous family. Next, visit the iconic Seven Mile Bridge, where breathtaking views of the turquoise waters await; it’s a fantastic spot for a family photo op. Don’t miss the opportunity to explore the charming streets of Key West, where you can visit the Ernest Hemingway Home and Museum, offering a glimpse into the life of the legendary author. For a unique experience, try a sunset sail with a local charter, allowing you to soak in the stunning sunset views while sipping on refreshing drinks. When it comes to accommodations, consider staying in the vibrant area of Islamorada, known as the Sport Fishing Capital of the World. Here, you’ll find a range of waterfront resorts with family-friendly amenities, ensuring a comfortable and pampered stay. With attentive service and easy access to both relaxation and adventure, your family will create unforgettable memories in this beautiful region.

Top Florida Keys Hotel Reviews

Explore a world of travel with Expedia