A long bridge spanning a river, surrounded by lush greenery and fields.

Find Resorts & Hotels with Spas in Greenville, MS

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Resorts & Hotels with Spas

Tonight
16 Oct - 17 Oct
Tomorrow
17 Oct - 18 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Greenville hotels with a spa

A salon setting with two people seated, a table with various skincare products, a vase with flowers, and neatly rolled towels in the background.
A restaurant with multiple dining areas, including booths and tables, with overhead lighting and a bar in the background.
A person sitting by a pool with clear blue water, wearing a white bikini and a large straw hat.
A table set for a formal dinner with white tablecloths, candles, and floral centerpieces.

1. Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa
Greenville
  • Relax in riverside luxury with spa treatments featuring hot stone massages, aromatherapy, and deep-tissue therapies in spacious suites.
AED 384
AED 422 total
includes taxes & fees
25 Oct - 26 Oct
Harlow's Casino Resort & Spa
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub
Breakfast included
4 stars
5 stars

Top Greenville Hotel Reviews

Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa

10/10 Excellent
"The staff and the room was excellent."
Sheri 1-night trip
Posted 18 hours ago
Harlow's Casino Resort & Spa

Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Forget the stress of everyday life and book yourself a lush spa hotel. Check out the live music scene and restaurants in Greenville—your day trip starts here. Enjoy the entertainment choices and riverfront during your vacation. Spa hotels are the perfect way to break away from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Harlow's Casino Resort & Spa is a top spa hotel featuring 3 restaurants, 3 bars, a casino, and a 24-hour fitness center. Enjoy a facial, body scrub, or detox wrap at the onsite spa.
How many spa hotels are there in Greenville?
Among Expedia's 18 accommodation options in Greenville, there is 1 spa hotel.
What's there to see and do in Greenville?
Take in some sights and attractions while you're in Greenville by visiting Trop Casino Greenville, Greenville Country Club, and Harlow's Casino Resort & Spa. If you have a bit of extra time while you're in the area, you might want to check out Mississippi River and 1927 Flood Museum.
What is a Greenville spa hotel?
Spa hotels in Greenville have on-site spas and offer services such as facials and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.