Greenville Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to AED 148 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Greenville

Find the best Greenville areas and neighborhoods for the activities you enjoy most. Learn more about Greenville
Aerial of Downtown Greenville SC South Carolina Skyline

Uptown Greenville

While visiting Uptown Greenville, you might make a stop by sights like Town Common and Greenville Museum of Art.

Find hotels in Uptown Greenville

Find the Best Greenville Vacation Packages

Greenville Hotel Deals

Best Western Plus Suites-Greenville

Best Western Plus Suites-Greenville

2.5 out of 5
2310 Greenville Boulevard NE Greenville NC
Fully refundableReserve now, pay when you stay
The price is AED 399 per night from Feb 15 to Feb 16
AED 399
AED 451 total
15 Feb - 16 Feb
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
All the staff were friendly and helpful. The entire hotel was clean, our room immaculate.

Reviewed on 31 January 2026

Best Western Plus Suites-Greenville
Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG

3 out of 5
930 Crosswind Street Greenville NC
Fully refundable
The price is AED 433 per night from Feb 12 to Feb 13
AED 433
AED 490 total
12 Feb - 13 Feb
includes taxes & fees
9.2/10 Wonderful! (279 reviews)
The room was great and the staff was very friendly. The towels were a little scratchy but other than that no complaints.

Reviewed on 3 February 2026

Staybridge Suites Greenville Medical Center by IHG
Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic

2 out of 5
450 Moye Blvd Greenville NC
Fully refundableReserve now, pay when you stay
The price is AED 228 per night from Feb 15 to Feb 16
AED 228
AED 258 total
15 Feb - 16 Feb
includes taxes & fees
7/10 Good! (1,004 reviews)
Yeah very helpful

Reviewed on 6 February 2026

Microtel Inn & Suites by Wyndham Greenville/University Medic
See all 272 properties in Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Greenville

ECU Health Medical Center

Though ECU Health Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Greenville while you are here.

ECU Health Medical Center

Greenville North Carolina Convention Center

Learn about the events happening at Greenville North Carolina Convention Center during your trip to Greenville.

Greenville North Carolina Convention Center

Greenville VA Medical Center

Though Greenville VA Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Greenville while you are here.

Greenville VA Medical Center

Frequently asked questions

How do I find cheap flights to Greenville that have flexible change policies?
At Expedia, we've been channeling our inner gymnast to give you the most flexible fares around. Just click on "No change fee" under the "Flexible change policies" subheading to find your perfect flight to Greenville.
Which airlines fly to Greenville?
You can fly into or near Greenville with American Airlines on any of its 268 monthly services. This includes 182 flights every month to Albert J. Ellis Airport (OAJ), and 86 to Pitt-Greenville Airport (PGV).
How can I find cheap tickets to Greenville?
In the last seven days, was the lowest price for a flight to Greenville. For even bigger savings, book ahead of time and be flexible with your dates. Search for your airfare to Greenville, then check out prices for nearby days by clicking on the "flexible dates" link above.
How much is a flight to Greenville?
There were loads of cheap fares up for grabs in the last seven days, with the cost of a return ticket to Greenville ranging between and . Many lucky vacationers nabbed one-way tickets from () for as little as .
What are the most popular airports to fly into in Greenville?
When it comes to working out which airport in Greenville to fly into, these are your choices:

  • Albert J. Ellis Airport (OAJ) - 182 flights per month.
  • Pitt-Greenville Airport (PGV) - 86 flights per month.

When is the cheapest time to fly to Greenville?
If you can be flexible with what day you jet off to Greenville, fly out early on in the week. The most affordable day to take off is usually Tuesday, followed closely by Monday. Saturday is typically the costliest day, with many people choosing to take off on the weekend.
How much is a plane ticket to Greenville?
In the last seven days, fares cost between and . Scroll through our terrific deals to Greenville, make a booking and then start packing your suitcase.
What months are the cheapest to book a flight to Greenville?
A good month to purchase affordable fares to Greenville is February. It's worth remembering that in the USA, an expensive time to secure a ticket is during the busy month of December.