Find hotels in South Main, Houston from AED 266

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Our top choices for South Main hotels

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,004 reviews)
"Good parking"
United States
joseph
The price is AED 290
AED 339 total
includes taxes & fees
6 Jun - 7 Jun
Wingate Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,004 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
United States
Cleota
The price is AED 422
AED 494 total
includes taxes & fees
7 Jun - 8 Jun
Comfort Suites Houston near Medical Center- NRG Stadium

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,290 reviews)
"Would stay again!"
United States
Austin
The price is AED 503
AED 589 total
includes taxes & fees
11 Jun - 12 Jun
Wyndham Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (867 reviews)
"My stay was perfect "
United States
Fredrick
The price is AED 353
AED 413 total
includes taxes & fees
8 Jun - 9 Jun
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is AED 277
AED 324 total
includes taxes & fees
9 Jun - 10 Jun
Quality Inn & Suites NRG Park - Medical Center

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,221 reviews)
"Wonderful place to stay!"
United States
Lisa
The price is AED 511
AED 597 total
includes taxes & fees
6 Jun - 7 Jun
Courtyard by Marriott Houston Intercontinental Airport

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (270 reviews)
"Clean room, and very helpful staff actually enjoyed our stay"
United States
Jessica
The price is AED 364
AED 425 total
includes taxes & fees
7 Jun - 8 Jun
Best Western Plus Pearland/Houston Medical Center Hotel

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (94 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
United States
Cruz
The price is AED 228
AED 266 total
includes taxes & fees
8 Jun - 9 Jun
Studio 6 Houston, TX – Pearland/Medical Center

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (41 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is AED 281
AED 329 total
includes taxes & fees
8 Jun - 9 Jun
Hotel Royale

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
19.4 km from South Main
9.0 out of 10, Wonderful, (71 reviews)
"We loved it, very nice employees and very clean."
United States
Jorge
The price is AED 322
AED 377 total
includes taxes & fees
8 Jun - 9 Jun
Palace Inn Blue 290 W 43rd & Bingle Rd

Crystal Inn Northeast Houston Downtown I-610

Crystal Inn Northeast Houston Downtown I-610
2.5 star property
Northside, 18.9 km from South Main
8.4 out of 10, Very Good, (209 reviews)
"Great price and nice rooms"
United States
Armando
The price is AED 248
AED 290 total
includes taxes & fees
7 Jun - 8 Jun
Crystal Inn Northeast Houston Downtown I-610

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,014 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
United States
Albert
The price is AED 323
AED 378 total
includes taxes & fees
6 Jul - 7 Jul
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,009 reviews)
"This was a great stay. We liked the suite, would have liked a microwave in there."
United States
Sara
The price is AED 373
AED 441 total
includes taxes & fees
5 Jul - 6 Jul
Doubletree by Hilton Houston Hobby Airport

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,201 reviews)
"The room was clean, staff was friendly, breakfast was great, and the area and location was nice and quiet."
United States
Dr. Cherie
The price is AED 309
AED 355 total
includes taxes & fees
7 Jun - 8 Jun
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,910 reviews)
"I would stay here again. Nice?"
United States
Alan
The price is AED 412
AED 485 total
includes taxes & fees
27 Jun - 28 Jun
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (176 reviews)
"It was very clean"
United States
Jesus
Palace Inn Blue Edgebrook

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
Midtown, 9.1 km from South Main
9.2 out of 10, Wonderful, (159 reviews)
"Great place. The staff is very friendly and the place is clean."
United States
Fernando
The price is AED 321
AED 375 total
includes taxes & fees
8 Jun - 9 Jun
Downtowner Inns - Houston Downtown

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,007 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
United States
Deanndra
The price is AED 308
AED 361 total
includes taxes & fees
28 Jun - 29 Jun
Tru by Hilton Houston Webster NASA

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,803 reviews)
"The staff were super helpful when needed something and the breakfast was a different buffet everyday made the stay even better"
Canada
Fawzia
The price is AED 512
AED 599 total
includes taxes & fees
6 Jul - 7 Jul
SpringHill Suites by Marriott Houston Intercontinental Arprt

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.0 out of 10, Very Good, (2,073 reviews)
"Clean convenient close to airport and food"
United States
Brian
The price is AED 341
AED 398 total
includes taxes & fees
8 Jun - 9 Jun
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,004 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
867 reviews
View
Premium bedding, pillowtop beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2
Good
1,290 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,004 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,003 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

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Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers a restaurant and an outdoor pool.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 66 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.