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Discover 5,985 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.0 out of 10, Very Good, (1431)
"I was charged $250 instead of Expedia rate of $156 !!!! Not happy about such discrepancies "
The price is AED 505
AED 585 total
includes taxes & fees
24 Oct - 25 Oct
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Downtown, Houston
Exterior
Club Quarters Hotel Downtown, Houston
4.0 star property
8.2 out of 10, Very Good, (4455)
"The easy check in , great location . Room was clean and organized daily "
The price is AED 356
AED 403 total
includes taxes & fees
26 Sep - 27 Sep
Club Quarters Hotel Downtown, Houston
The Whitehall Houston
Exterior
The Whitehall Houston
4.0 star property
8.4 out of 10, Very Good, (1067)
"Great location and beautiful rooms. "
The price is AED 525
AED 598 total
includes taxes & fees
20 Oct - 21 Oct
The Whitehall Houston
Blossom Hotel Houston
Room
Blossom Hotel Houston
4.0 star property
9.2 out of 10, Wonderful, (2623)
"Great property, staff is very welcoming and helpful."
The price is AED 526
AED 615 total
includes taxes & fees
29 Sep - 30 Sep
Blossom Hotel Houston
Marriott Marquis Houston
Exterior
Marriott Marquis Houston
4.0 star property
8.8 out of 10, Excellent, (1014)
"It was nice and I love the pool and staff wa every professional and nice "
The price is AED 988
AED 1,258 total
includes taxes & fees
11 Oct - 12 Oct
Marriott Marquis Houston
Hilton Americas-Houston
Exterior
Hilton Americas-Houston
4.0 star property
9.2 out of 10, Wonderful, (1131)
"We Came to Houston for Da Bears vs Texas game. The property was very clean, updated and comfortable. Our room was clean, cool, and the bed was very comfortable. The property is close to discovery green and there are bars and restaurants nearby. The rooftop pool and outdoor area were really nice. Overall, it was an excellent stay "
The price is AED 809
AED 936 total
includes taxes & fees
4 Oct - 5 Oct
Hilton Americas-Houston
Hyatt Regency Houston Downtown
Room
Hyatt Regency Houston Downtown
4.0 star property
9.0 out of 10, Wonderful, (1776)
"An excellent choice for business trips in the heart of downtown Houston. The Einstein Bros shop is a huge plus."
The price is AED 731
AED 878 total
includes taxes & fees
5 Oct - 6 Oct
Hyatt Regency Houston Downtown
Hyatt Place Houston Downtown
Exterior
Hyatt Place Houston Downtown
3.0 star property
9.0 out of 10, Wonderful, (1412)
"This hotel is somewhere I would love to stay again. Loved how my room was set up and the staff were great. They made checking in very easy. There are also tons of great restaurants in walking distance of the hotel. Although they do not offer room service, they do have a 24 hour grab and go and Starbucks. Definitely recommend. "
The price is AED 579
AED 671 total
includes taxes & fees
13 Oct - 14 Oct
Hyatt Place Houston Downtown
Holiday Inn Houston Downtown, an IHG Hotel
Exterior
Holiday Inn Houston Downtown, an IHG Hotel
3.0 star property
8.6 out of 10, Excellent, (1009)
"The restaurant that was downstairs and the pleasantness of the staff. I will be back!"
The price is AED 328
AED 448 total
includes taxes & fees
26 Sep - 27 Sep
Holiday Inn Houston Downtown, an IHG Hotel
C. Baldwin, Curio Collection by Hilton
Exterior
C. Baldwin, Curio Collection by Hilton
4.0 star property
8.4 out of 10, Very Good, (854)
"Maintenance needed in the bathroom."
The price is AED 621
AED 810 total
includes taxes & fees
12 Oct - 13 Oct
C. Baldwin, Curio Collection by Hilton
Le Meridien Houston Downtown
Exterior
Le Meridien Houston Downtown
4.0 star property
8.6 out of 10, Excellent, (818)
"I recently stayed at tge Le Meridien in Houston and had an overall fantastic experience. One of the highlights was the rooftop, which had great vibes, especially at night with music setting the perfect atmosphere. The view from my room was incredible, offering a clear sight of the stadium, which was a pleasant surprise. While the restaurant menu didn't have an extensive range of options, it offered exactly what I needed. The staff was friendly and added a lot of energy and excitement to my stay....
The price is AED 585
AED 672 total
includes taxes & fees
26 Sep - 27 Sep
Le Meridien Houston Downtown
Rusk House Serviced Apartments
Property amenity
Rusk House Serviced Apartments
4.5 star property
9.0 out of 10, Wonderful, (59)
"Easy check-in. Great art. Funky. Spacious. Convenient to convention center."
The price is AED 606
AED 709 total
includes taxes & fees
21 Oct - 22 Oct
Rusk House Serviced Apartments
The Royal Sonesta Houston Galleria
Exterior
The Royal Sonesta Houston Galleria
4.0 star property
8.2 out of 10, Very Good, (1008)
"Very nice, professionally run hotel in a nice area with great amenities. Elevator in parking lot was broken, which was an inconvenience."
The price is AED 613
AED 795 total
includes taxes & fees
11 Oct - 12 Oct
The Royal Sonesta Houston Galleria
Cambria Hotel Houston Downtown Convention Center
Bar (on property)
Cambria Hotel Houston Downtown Convention Center
3.0 star property
8.8 out of 10, Excellent, (1398)
"Water pressure was horrible at the lavatory. The room we booked was not available but we couldn’t get a price reduction because we booked from outside the hotel. Overall it was a nice place to stay easy access to Minute Maid Park where we were going."
The price is AED 459
AED 527 total
includes taxes & fees
26 Sep - 27 Sep
Cambria Hotel Houston Downtown Convention Center
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Lobby
Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
9.0 out of 10, Wonderful, (1005)
"The property was beautiful and clean. I loved the rooftop pool and soaking tub. My only disappointment was the $20 cost for the breakfast buffet.. "
The price is AED 591
AED 688 total
includes taxes & fees
29 Sep - 30 Sep
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Moxy Houston Downtown
Front of property
Moxy Houston Downtown
3.0 star property
9.0 out of 10, Wonderful, (216)
"Great place with amazing staff!"
The price is AED 459
AED 533 total
includes taxes & fees
29 Sep - 30 Sep
Moxy Houston Downtown
The Laura Hotel, Houston Downtown, Autograph Collection
Exterior
The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
8.8 out of 10, Excellent, (1005)
"perfect stay"
The price is AED 731
AED 845 total
includes taxes & fees
11 Oct - 12 Oct
The Laura Hotel, Houston Downtown, Autograph Collection
InterContinental Houston, an IHG Hotel
Exterior
InterContinental Houston, an IHG Hotel
4.0 star property
9.4 out of 10, Exceptional, (1006)
"I tried using the pool and I was with a guest with a disability. The pool’s ada access arm was not working and didn’t seem the hotel kept up with the arm. Technician was nice and tried to get it working but was unsuccessful. "
The price is AED 595
AED 734 total
includes taxes & fees
19 Oct - 20 Oct
InterContinental Houston, an IHG Hotel
Thompson Houston, by Hyatt
Exterior
Thompson Houston, by Hyatt
4.0 star property
9.2 out of 10, Wonderful, (74)
"Friendly staff, shout out to Victor he was brilliant "
The price is AED 1,021
AED 1,282 total
includes taxes & fees
28 Sep - 29 Sep
Thompson Houston, by Hyatt
Hyatt Place Houston Medical Center
Exterior
Hyatt Place Houston Medical Center
3.0 star property
9.0 out of 10, Wonderful, (1008)
"All good"
The price is AED 493
AED 566 total
includes taxes & fees
24 Sep - 25 Sep
Hyatt Place Houston Medical Center
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Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center, an IHG Hotel and Wyndham Houston near NRG Park/Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 79 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.