Isle of Palms Vacations
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Where to stay in Isle of Palms
Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Isle of Palms Hotel Deals
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH Jacksonville FL
The price is AEDĀ 486 per night from Aug 8 to Aug 9
AEDĀ 486
AEDĀ 552 total
8 Aug - 9 Aug
includes taxes & fees
9.4/10 Exceptional! (559 reviews)
"Great clean hotel. The location is perfect for Mayo Clinic guests. Our bed was comfortable and the room is laid out very nicely with a small kitchen, full-size refrigerator, and a walk-in shower. We had dinner in the hotel bar area and it was very good. The staff is very funny."
Reviewed on 17 July 2026
Margaritaville Jacksonville Beach
715 1st St N Jacksonville Beach FL
Fully refundableReserve now, pay when you stay
The price is AEDĀ 618 per night from Aug 2 to Aug 3
AEDĀ 618
AEDĀ 701 total
2 Aug - 3 Aug
includes taxes & fees
8.8/10 Excellent! (4,175 reviews)
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Reviewed on 18 July 2026
Wyndham Garden Jacksonville
4660 Salisbury Road Jacksonville FL
Fully refundableReserve now, pay when you stay
The price is AEDĀ 287 per night from Aug 12 to Aug 13
AEDĀ 287
AEDĀ 326 total
12 Aug - 13 Aug
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.