The Best Resorts & Hotels with Spas in Istron from AED 227 in 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Istron hotels with a spa

A poolside area with lounge chairs and a pergola overlooking a mountainous landscape.

1. Istron Collection Villas

Agios Nikolaos

Seaside serenity awaits at this Mediterranean retreat with rejuvenating spa treatments and waterfront relaxation.

AED 767 total

includes taxes & fees

27 Nov - 28 Nov

A modern interior with a curved seating area, a hanging light fixture, and a view into another room.

2. Minos Palace Resort - Adults Only

Agios Nikolaos

Eco-certified resort offers seaside serenity with rejuvenating Ayurvedic treatments at Ananea Wellness spa.

AED 1,022 total

includes taxes & fees

11 Nov - 12 Nov

A bed with a white duvet, a yellow towel, and a pair of sunglasses on the bed.

3. Naiades Marina Hotel

Agios Nikolaos

Relax at a beachside haven where daily spa treatments, a seasonal outdoor pool, and sun loungers create the perfect wellness retreat.

AED 303 total

includes taxes & fees

11 Nov - 12 Nov

A modern bathroom with a large window, a built-in sink, and a minimalist design.

4. Minos Beach Art Hotel, a Member of Design Hotels

Agios Nikolaos

Mediterranean serenity awaits at eco-certified spa hotel featuring private beach, outdoor pool, and sauna.

AED 1,239 total

includes taxes & fees

11 Nov - 12 Nov

A spa room with two massage tables, towels, and a bouquet of yellow flowers.

5. Astron Hotel

Ierapetra

Rejuvenating spa getaway awaits at this seaside hotel offering facials, aromatherapy, and reflexology treatments in a tranquil setting.

AED 270 total

includes taxes & fees

10 Dec - 11 Dec

A modern pool area with a glass balustrade, lounge chairs, and a view of the ocean at sunset.

6. The Noverian Scenic Crete 5 Star Hilltop Villa Resort & Spa

Hersonissos

Rejuvenating spa retreat with mountain views offers luxurious body treatments and facials in a tranquil hilltop setting with indoor pool.

AED 275 total

includes taxes & fees

15 Nov - 16 Nov

A tented accommodation with a bed, bedside table, lamp, and a view of the sunset over the sea.

7. Eco Dome Crete

Agios Nikolaos

AED 661 total

includes taxes & fees

11 Nov - 12 Nov

View all properties

Choose what matters most at spa hotels in Istron

Pool

Breakfast included

Top Istron Hotel Reviews

Istron Collection Villas

Agios Nikolaos

10/10 Excellent

We stayed at Istron Collection Villas in September 2026, and our experience was absolutely wonderful from start to finish. Our villa was beautiful, clean, comfortable, and having our own private pool made the stay even more special. The staff truly made our visit memorable. Everyone at the hotel and throughout the property was incredibly friendly, welcoming, and helpful. The customer service was outstanding! One of the sweetest surprises was when the staff overheard that we were celebrating a...

John

Minos Palace Resort - Adults Only

Agios Nikolaos

10/10 Excellent

Nothing bad to say about this resort. Upon arrival, we were upgraded from a Ocean View Suite to the Ocean View Suite with Private Swimming Pool at no additional charge. The Greek hospitality was immediately recognizable. They gave us a free massage, bottle of wine and water, fruit basket and another free bottle of wine coupon to be used with dinner at the resort. The room was spacious with new amenities. The dinner restaurant was a buffet that cost 25 euro p/p. I would say that may have been the...

Anonymous traveler

Minos Beach Art Hotel, a Member of Design Hotels

Agios Nikolaos

10/10 Excellent

This is a luxurious, beautiful hotel set in one of the most beautiful surroundings possible. Flowers, gardens, art, good food, amazing access to the sea. A very special place. We were upgraded to a villa with private pool and this was phenomenal. The villa was large and very well designed. Our only complaint was that the shower was very small. There was a separate bathtub in the room with a gorgeous view that made up for it, however.

Anonymous traveler

Naiades Marina Hotel

Agios Nikolaos

10/10 Excellent

This is a very nice hotel near the marina, a bit away from the chaos of the center of A.N. but still close to restaurants, the beach, etc. The perfect location in my opinion. The hotel staff were very welcoming and helpful. The room itself was fairly basic but clean. We booked a room with a large deck - enough room for 2 loungers, a bistro set, and a bit tub (with unheated water perfect for cooling off in). We spent quite a bit of time on that deck. Breakfast was very good as well. Good...

Michelle

The Noverian Scenic Crete 5 Star Hilltop Villa Resort & Spa

Hersonissos

10/10 Excellent

Mohamd Dubayyan

Frequently Asked Questions

Looking to vacation at a spa hotel in Istron?

Treat yourself to some pampering and book a hotel with a spa. Immerse yourself in nature at the beaches and mountain views in Istron. Spa hotels are the perfect way to break out of your routine and add a layer of luxury to your holiday.

What is the best spa hotel in Istron?

Istron Bay Hotel is a top beachfront spa hotel featuring tennis courts, a hair salon, a bar, and an outdoor pool. Enjoy a facial or massage at Aegeos Spa.

How many spa hotels are there in Istron?

Among Expedia's 49 accommodation options in Istron, there is 1 spa hotel.

What's there to see and do in Istron?

Take in the sights and attractions that Istron offers with a visit to Voulisma Beach, Agios Panteleímonas, and Golden Beach. If you have extra time while you're in the area, you might want to stop by Istro Beach and Pachia Ammos Beach.

What is a Istron spa hotel?

Spa hotels in Istron have full on-site spas which offer services like couples massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia

Agios Nikolaos Town Vacations
Standard Link for Agios Nikolaos Town Vacations

Find Resorts & Hotels with Spas in Istron

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Istron hotels with a spa

1. Istron Collection Villas

2. Minos Palace Resort - Adults Only

3. Naiades Marina Hotel

4. Minos Beach Art Hotel, a Member of Design Hotels

5. Astron Hotel

6. The Noverian Scenic Crete 5 Star Hilltop Villa Resort & Spa

7. Eco Dome Crete

Choose what matters most at spa hotels in Istron

Top Istron Hotel Reviews

Istron Collection Villas

10/10 Excellent

Frequently Asked Questions

Looking to vacation at a spa hotel in Istron?

What is the best spa hotel in Istron?

How many spa hotels are there in Istron?

What's there to see and do in Istron?

What is a Istron spa hotel?

Explore a world of travel with Expedia