A river, a large white building, and a cityscape.

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Check availability on Jackson Business Hotels

Tonight
20 Oct - 21 Oct
Tomorrow
21 Oct - 22 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Jackson business-friendly hotels

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A hotel room with two beds, a brick wall, and a wooden headboard.

1. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Lyn
AED 294
AED 311 total
includes taxes & fees
25 Oct - 26 Oct
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A hotel room with two beds, a nightstand, a lamp, and a chair.

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
AED 293
AED 318 total
includes taxes & fees
1 Nov - 2 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

3. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
United States
VICTORIA
AED 278
AED 301 total
includes taxes & fees
9 Nov - 10 Nov
Comfort Suites Jackson-Cape Girardeau
A modern retail area with a display of local items and snacks.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

4. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
United States
Shannon
AED 328
AED 374 total
includes taxes & fees
26 Oct - 27 Oct
Tru By Hilton Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

5. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
United States
Rebecca
AED 364
AED 414 total
includes taxes & fees
19 Nov - 20 Nov
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Chris
AED 367
AED 414 total
includes taxes & fees
25 Oct - 26 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

7. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
United States
DENNIS
AED 331
AED 373 total
includes taxes & fees
25 Oct - 26 Oct
Drury Inn & Suites Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

8. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
United States
Troy
AED 264
AED 298 total
includes taxes & fees
25 Oct - 26 Oct
Pear Tree Inn Cape Girardeau West
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

9. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
United States
Dayanita
AED 219
AED 247 total
includes taxes & fees
1 Nov - 2 Nov
Quality Inn Cape Girardeau North
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
AED 372
AED 419 total
includes taxes & fees
25 Oct - 26 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
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Top Jackson Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Lots of parking , clean room ,beautiful atmosphere breakfast was good."
Geraldine 1-night trip
Posted 18 hours ago
Drury Inn & Suites Jackson MO
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

10/10 Excellent
"I chose this motel due to it being close to the car rental agency I used and the bus stop for Greyhound. Sidewalks on Kingshighway would have helped but that is on the city of Cape Girardeau! :-}"
Sam 1-night trip
Posted 23 hours ago
Quality Inn Cape Girardeau North
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Stayed here for a long weekend motorcycle trip. The hotel is conveniently located near many shopping and dining choices. The room was basic but clean and quiet, and lots of channels on the tv! Staff were super friendly and helpful. I will definitely stay here again the next time I am in Cape Girardeau."
Robert 3-night trip
Posted 1 day ago
Pear Tree Inn Cape Girardeau West
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

10/10 Excellent
"Overall very nice place clean excellent staff awesome breakfast and very good coffee bed very comfortable very nice updated rooms.. I plan on staying there again 😀"
Jeff 5-night trip
Posted 4 days ago
Comfort Suites Jackson-Cape Girardeau
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

8/10 Good
"."
karen 1-night trip
Posted 11 days ago
Days Inn by Wyndham Perryville