A river, a large white building, and a cityscape.

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Check availability on Jackson Business Hotels

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for Jackson business-friendly hotels

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

1. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,004 reviews)
"Clean room affordable and great breakfast I would definitely go back!"
United States
Lyn
The price is AED 294
AED 311 total
includes taxes & fees
1 Nov - 2 Nov
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (885 reviews)
"Breakfast was good."
United States
J
The price is AED 293
AED 318 total
includes taxes & fees
1 Nov - 2 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

3. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.0 out of 10, Very good, (785 reviews)
"Overall very nice place clean excellent staff awesome breakfast and very good coffee bed very comfortable very nice updated rooms.. I plan on staying there again 😀"
United States
Jeff
The price is AED 278
AED 301 total
includes taxes & fees
17 Nov - 18 Nov
Comfort Suites Jackson-Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,009 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is AED 367
AED 414 total
includes taxes & fees
31 Oct - 1 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

5. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,004 reviews)
"The food was excellent"
United States
DENNIS
The price is AED 331
AED 373 total
includes taxes & fees
1 Nov - 2 Nov
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

6. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is AED 349
AED 397 total
includes taxes & fees
26 Nov - 27 Nov
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,003 reviews)
"Room was clean and staff was very friendly"
United States
Troy
The price is AED 264
AED 298 total
includes taxes & fees
1 Nov - 2 Nov
Pear Tree Inn Cape Girardeau West
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

8. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.0 out of 10, Good, (814 reviews)
"Clean rooms, nice staff"
United States
Dayanita
The price is AED 218
AED 246 total
includes taxes & fees
8 Nov - 9 Nov
Quality Inn Cape Girardeau North
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

9. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (237 reviews)
"Great hotel…!!"
United States
Carlos
The price is AED 372
AED 419 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

10. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (855 reviews)
"Stayed here overnight for a wedding. Room was clean and they allowed us to check in early with no fee. Location is ideal, being walking distance from a Cracker Barrel and a breakfast place. Stores like Target and Walmart are only about a 5 minute drive."
United States
Brittany
The price is AED 343
AED 387 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Cape Girardeau I 55 East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Jackson Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Clean and tidy, friendly staff. Pet friendly. Easy access from the highway. In and out with a good night's sleep and no hassle"
eugene 1-night trip
Posted 3 hours ago
Drury Inn & Suites Cape Girardeau