The Best Business Hotels in Jackson, MO from AED 247 in 2026 | Expedia

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Our top choices for Jackson business-friendly hotels

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A hotel room with two beds, a nightstand, a lamp, and a chair.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

1. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

United States

Elaine

AED 297

AED 321 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

A hotel room with two beds, a brick wall, and a wooden headboard.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

2. Drury Inn & Suites Jackson MO

Jackson

United States

Thomas

AED 301

AED 318 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

3. Comfort Suites Jackson-Cape Girardeau

Jackson

United States

VICTORIA

AED 278

AED 301 total

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

United States

Sandra

AED 367

AED 414 total

includes taxes & fees

5 Oct - 6 Oct

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

5. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

United States

ELAINE

AED 364

AED 414 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

6. Pear Tree Inn Cape Girardeau West

Cape Girardeau

United States

Elizabeth

AED 264

AED 298 total

includes taxes & fees

11 Oct - 12 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

United States

Carlos

AED 372

AED 419 total

includes taxes & fees

8 Oct - 9 Oct

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

8. Drury Inn & Suites Cape Girardeau

Cape Girardeau

United States

Teresa

AED 331

AED 373 total

includes taxes & fees

5 Oct - 6 Oct

View all properties

Top Jackson Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"No complaints"

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent

"One of the best hotels I have stayed in."

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

10/10 Excellent

"Great place great breakfast great room staff was great"

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"trodo estubo excelente gracias por sus servicios"

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Upgraded to a 2 room suite. Rey nice room lots of storage. Would definitely stay here again."