A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
20 Sep - 21 Sep
Tomorrow
21 Sep - 22 Sep
Next weekend
25 Sep - 27 Sep
In two weeks
2 Oct - 4 Oct

Our top choices for Key Largo luxury hotels

1. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
AED 804
AED 1,052 total
includes taxes & fees
21 Sep - 22 Sep
Reefhouse Resort & Marina

2. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
AED 966
AED 1,289 total
includes taxes & fees
4 Oct - 5 Oct
Playa Largo Resort & Spa, Autograph Collection

3. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
AED 870
AED 1,182 total
includes taxes & fees
29 Sep - 30 Sep
Baker's Cay Resort Key Largo, Curio Collection by Hilton

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
AED 1,521
AED 1,944 total
includes taxes & fees
1 Oct - 2 Oct
The Islands of Islamorada

5. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
AED 732
AED 1,092 total
includes taxes & fees
27 Sep - 28 Sep
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

6. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
AED 509
AED 841 total
includes taxes & fees
21 Sep - 22 Sep
Cheeca Lodge & Spa

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
AED 711
AED 1,048 total
includes taxes & fees
30 Sep - 1 Oct
Islander Resort

8. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
AED 488
AED 818 total
includes taxes & fees
22 Sep - 23 Sep
Amara Cay Resort
View all properties

Top Key Largo Hotel Reviews

Waterside Suites & Marina

Waterside Suites & Marina

8/10 Good
"Esther was so nice and helpful. The rooms are good but depending on the location you hear a lot of music from across the canal"
Alicia 2-night trip
Posted 4 hours ago
Waterside Suites & Marina
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Very pleasant stay would recommend to anyone looking for a fun get away"
Payton 2-night trip
Posted 4 hours ago
Sunset Cove Beach Resort
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"The property was clean and the staff very polite"
Ruddy 1-night trip
Posted 1 day ago
Hampton Inn Key Largo Manatee Bay
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"Clean room excellent staff good location recommend"
Tania 2-night trip
Posted 2 days ago
Playa Largo Resort & Spa, Autograph Collection
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"This is so peaceful. We have been 5x now and if you are looking for quaint and peaceful this is it. Very clean very nice people. Literally the only drawback is we cannot bring our jetskis, but get it."
kimberly 1-night trip
Posted 3 days ago
The Pelican Key Largo Cottages
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"Clean rooms and staff was nice. We really liked the place. Will come back"
Cathy 1-night trip
Posted 7 days ago
Amoray Dive Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.