Find Luxury Hotels in Key Largo, FL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo Luxury Hotels

This weekend
Next weekend

Our top choices for Key Largo luxury hotels

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
The price is AED 1,319
AED 1,686 total
includes taxes & fees
20 May - 21 May
Playa Largo Resort & Spa, Autograph Collection

Reefhouse Resort & Marina

Reefhouse Resort & Marina
4.5 star property
Key Largo
9.4 out of 10, Exceptional, (1,408 reviews)
The price is AED 1,098
AED 1,382 total
includes taxes & fees
5 May - 6 May
Reefhouse Resort & Marina

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
4.0 star property
Key Largo
8.6 out of 10, Excellent, (1,055 reviews)
  • cleanliness
    Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
The price is AED 1,246
AED 1,604 total
includes taxes & fees
25 May - 26 May
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,317 reviews)
  • cleanliness
    Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
The price is AED 1,108
AED 1,515 total
includes taxes & fees
10 May - 11 May
Cheeca Lodge & Spa

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.8 out of 10, Exceptional, (74 reviews)
The price is AED 2,204
AED 2,682 total
includes taxes & fees
4 May - 5 May
The Islands of Islamorada

Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,009 reviews)
  • cleanliness
    Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
The price is AED 834
AED 1,186 total
includes taxes & fees
26 May - 27 May
Islander Resort

Amara Cay Resort

Amara Cay Resort
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1,267 reviews)
  • cleanliness
    Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
The price is AED 689
AED 1,044 total
includes taxes & fees
20 May - 21 May
Amara Cay Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
4.0 star property
Islamorada
9.0 out of 10, Wonderful, (192 reviews)
  • cleanliness
    Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
The price is AED 1,090
AED 1,470 total
includes taxes & fees
19 May - 20 May
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

La Siesta Resort & Villas

La Siesta Resort & Villas
4.0 star property
Matecumbe
8.6 out of 10, Excellent, (1,002 reviews)
The price is AED 616
AED 961 total
includes taxes & fees
12 May - 13 May
La Siesta Resort & Villas

Find Peace - Tiny House in Japanese Garden

Find Peace - Tiny House in Japanese Garden
4.0 star property
Homestead
9.2 out of 10, Wonderful, (11 reviews)
The price is AED 533
AED 1,184 total
includes taxes & fees
29 Apr - 30 Apr
Find Peace - Tiny House in Japanese Garden
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Key Largo Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
Known for its sunsets and boating, Key Largo also has some interesting things to see and do including Everglades National Park, so you may want to take in the local sights during your visit.
What's the best high-end place to stay in Key Largo?
Reefhouse Resort & Marina is a luxury hotel with a private beach and 3 restaurants, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Playa Largo Resort & Spa, Autograph Collection.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Everglades National Park, Jimmy Johnson's Big Chill, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.