A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo Luxury Hotels

Tonight
14 Oct - 15 Oct
Tomorrow
15 Oct - 16 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Key Largo luxury hotels

An aerial view of a resort with a large pool, palm trees, and a beach.
A beachside patio with lounge chairs, a table, and a view of the ocean.
A restaurant with wooden tables and chairs, a bar area, and a view of the sea.
A pool area with lounge chairs and umbrellas, a clear sky, and palm trees.

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
AED 966
AED 1,289 total
includes taxes & fees
1 Nov - 2 Nov
Playa Largo Resort & Spa, Autograph Collection
A dining area with tables set for two, overlooking a beach with palm trees and a sunset view.
A poolside area with blue chairs and a thatched-roof structure.
A spacious bar area with high ceilings and large windows, offering views of the ocean.
A spacious living room with large windows, comfortable seating, and decorative plants.

2. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
AED 804
AED 1,052 total
includes taxes & fees
15 Oct - 16 Oct
Reefhouse Resort & Marina
A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A spacious lobby with a seating area, a bar, and a large window providing a view of the outdoors.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.
A bar area with a thatched roof, wooden chairs, and a view of the ocean.

3. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
AED 614
AED 959 total
includes taxes & fees
19 Oct - 20 Oct
Cheeca Lodge & Spa
A balcony with a wooden table, two chairs, and a view of the ocean and palm trees.
A beachside patio with a thatched roof, two lounge chairs, and a view of the ocean.
A resort with multiple white buildings, each featuring balconies and surrounded by lush greenery and palm trees.
A pool area with clear blue water, white lounge chairs, and palm trees.

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
AED 1,917
AED 2,398 total
includes taxes & fees
15 Oct - 16 Oct
The Islands of Islamorada
View all properties

Top Key Largo Hotel Reviews

Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"The beach proximity was much better than most other hotels in the Keys. They have small walk-in sand beaches. Much better than coral or concrete barriers or rocks at other hotels along the Keys. This area has sea grass in the shallows. Not expecting to walk on grass, but it was fine. This location on the gulf side of the Keys had no Sargassum while the Atlantic side had significant decaying Sargassum in the summer. This is not your typical sandy gulf beach, but it was nice with no waves and calm warm water to lounge in. Watching the sunset while lounging in the water was a wonderful new experience. The pool area was very nice and convenient to the beach. Covered self parking was awesome considering the sunny climate. Nice bonus feature is the convenience of the onsite watersports business. We enjoyed a jet ski tour of the mangroves and Highway 1. Very convenient to restaurants and diving/snorkeling businesses."
Leonard 4-night trip
Posted 16 hours ago
Reefhouse Resort & Marina
Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent
"Fabulous resort, great arrangement with Snook bar next door. The bantams were intriguing. Room good, but, dirty pair of underpants left in a draw by a previous guest."
Rene 1-night trip
Posted 19 hours ago
Bayside Inn Key Largo
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"Muy bonito lugar"
Dayner 1-night trip
Posted 21 hours ago
Amoray Dive Resort
Gilbert's Resort

Gilbert's Resort

10/10 Excellent
"La habitación fue un éxito muy linda y limpia grande y no hay de que quejarse, la piscina súper limpia, la atención de los meseros muy amable y atención buena"
Reimundo 1-night trip
Posted 2 days ago
Gilbert's Resort
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"Everything was amazing!!! Beautiful hotel and great location."
Jorge 4-night trip
Posted 2 days ago
Playa Largo Resort & Spa, Autograph Collection
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Everything was wonderful, clean room, nice and cool. Beach area had floats and paddle boards for guest use. Enjoyed a short walk to a great restaurant."
Tracy 1-night trip
Posted 2 days ago
Sunset Cove Beach Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 4 restaurants and 3 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.