Find Resorts & Hotels with Spas in Little Italy, CA

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Check availability on Little Italy Resorts & Hotels with Spas

Our top choices for Little Italy hotels with a spa

Body treatments, aromatherapy, body wraps, body scrubs, facials
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1857)
"Enjoyed my stay"
United States
Brandon
The price is AED 366
AED 605 total
includes taxes & fees
4 Jan - 5 January 2026
Hilton San Diego Bayfront
3 outdoor pools, cabanas (surcharge), pool umbrellas
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1570)
"Loved our stay "
United States
Jeremy
The price is AED 430
AED 688 total
includes taxes & fees
17 Dec - 18 Dec
Hyatt Regency Mission Bay Spa and Marina
Facials, 2 treatment rooms, massages
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1061)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is AED 497
AED 682 total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Hot stone massages, prenatal massages, sports massages, body scrubs
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1309)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is AED 432
AED 662 total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
Couples treatment rooms, sauna, hot tub, steam room, body treatments
Loews Coronado Bay Resort

Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1066)
"My stay was wonderful! "
United States
Jeanine
The price is AED 657
AED 908 total
includes taxes & fees
14 Dec - 15 Dec
Loews Coronado Bay Resort
Couples treatment rooms, body treatments, hot stone massages
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2946)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is AED 559
AED 642 total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Water view
Kona Kai San Diego

Kona Kai San Diego

Kona Kai San Diego
4.0 star property
Point Loma
8.2 out of 10, Very Good, (1000)
"had a wonderful time for our honey moon here "
United States
Anna
The price is AED 553
AED 856 total
includes taxes & fees
10 Jan - 11 January 2026
Kona Kai San Diego
Exterior
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
Point Loma
8.8 out of 10, Excellent, (1554)
"Every time i have stayed here everything is always clean...no complaints!"
United States
Joseline
The price is AED 420
AED 483 total
includes taxes & fees
4 Jan - 5 January 2026
Best Western Plus Island Palms Hotel & Marina
5 outdoor pools, a heated pool, pool umbrellas, sun loungers
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay
8.6 out of 10, Excellent, (2351)
"Great stay, top tier service and excellent customer care "
Canada
Meriem
The price is AED 475
AED 740 total
includes taxes & fees
15 Dec - 16 Dec
Paradise Point Resort & Spa
Dinner served
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2049)
"It was an amazing stay "
United States
Alejandra
The price is AED 684
AED 959 total
includes taxes & fees
4 Jan - 5 January 2026
Omni San Diego Hotel at the Ballpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Little Italy Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"excellent hotel pre-cruise. great appetizers at Happy Hour! Very nice room."
Patricia 1-night trip
Posted 1 day ago
Sheraton San Diego Resort

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Frequently asked questions

Looking to vacation at a spa hotel in Little Italy?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend the restaurants in Little Italy. Enjoy the museums and cafes during your vacation. Spa hotels are a great way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Little Italy?
When you're in Little Italy, enjoy exploring the sights and attractions here including Maritime Museum of San Diego, San Diego Bay, and Star of India. If you have a little extra time during your trip, you might want to make a stop at San Diego Zoo and Port of San Diego.
What is a Little Italy spa hotel?
Spa hotels in Little Italy feature full on-site spas and offer services such as couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.