A wooden cart with large wheels in a desert landscape with ancient, earthen structures in the background.

Search Vacation Homes in Mesilla

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
25 Sep - 27 Sep
In two months
6 Nov - 8 Nov
In three months
4 Dec - 6 Dec
In four months
1 Jan - 3 Jan

Our top choices for Mesilla vacation homes

Property grounds

1. Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian

Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian
Mesilla
10.0 out of 10, Exceptional, (95 reviews)
"Outstanding. Will definitely stay again."
United States
Glenn N.
Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian
Exterior detail

2. 2 bed, yard, pet friendly in Historic Mesilla.

2 bed, yard, pet friendly in Historic Mesilla.
Las Cruces
10.0 out of 10, Exceptional, (2 reviews)
"We liked the location and homey feeling. Nice to have a yard and chiminea, though we didn't use it this trip."
United States
Tom K.
The price is AED 404
AED 960 total
includes taxes & fees
12 Sep - 13 Sep
2 bed, yard, pet friendly in Historic Mesilla.
Interior

3. Charming 2-bedroom Casita In Mesilla Park Casita Conway #5

Charming 2-bedroom Casita In Mesilla Park Casita Conway #5
Las Cruces
9.8 out of 10, Exceptional, (10 reviews)
"Amazing place. Perfect for our stay! "
United States
Douglas N.
Charming 2-bedroom Casita In Mesilla Park Casita Conway #5
Coffee/tea maker, fridge, microwave, oven

4. Charming 1-bedroom house with WiFi, AC Mesilla Park Las Cruces Casita Conway 2

Charming 1-bedroom house with WiFi, AC Mesilla Park Las Cruces Casita Conway 2
Las Cruces
9.2 out of 10, Wonderful, (16 reviews)
"Great property and host - I wish we had reasons to return to Las Cruces!"
United States
Lori L.
The price is AED 275
AED 597 total
includes taxes & fees
13 Sep - 14 Sep
Charming 1-bedroom house with WiFi, AC Mesilla Park Las Cruces Casita Conway 2
Dining

5. Unique 1-bedroom casita in Mesilla Park with hot tub

Unique 1-bedroom casita in Mesilla Park with hot tub
Las Cruces
9.8 out of 10, Exceptional, (30 reviews)
"The kitchen was fully equippedLaundry room met are needsVery affordableHost very accessible for questions"
United States
angie r.
The price is AED 331
AED 597 total
includes taxes & fees
14 Sep - 15 Sep
Unique 1-bedroom casita in Mesilla Park with hot tub
Coffee/tea maker, fridge, microwave, oven

6. 1 bedroom near NMSU. W/D in unit/pets welcome.

1 bedroom near NMSU. W/D in unit/pets welcome.
Las Cruces
10.0 out of 10, Exceptional, (2 reviews)
"This property was a perfect stop over for a couple of nights. What made it so perfect is that we could bring our fur babies with us. We especially appreciated the fenced in back yard. The house itself had all the modern conveniences of home. The fresh eggs and muffins were a wonderful surprise."
United States
Debbie B.
1 bedroom near NMSU. W/D in unit/pets welcome.
TV, fireplace

7. 3 bed 2 bath Hacienda near Downtown and NMSU.

3 bed 2 bath Hacienda near Downtown and NMSU.
Las Cruces
10.0 out of 10, Exceptional, (1 review)
"Such an adorable place to stay! We stopped through for one night on our way to our destination. The beds were comfortable and the house was so unique. We loved the fresh eggs for breakfast!"
United States
Sarah E.
3 bed 2 bath Hacienda near Downtown and NMSU.
TV

8. 2 bd/2bth near NMSU and Memorial Medical Center

2 bd/2bth near NMSU and Memorial Medical Center
Las Cruces
10.0 out of 10, Exceptional, (4 reviews)
"Delightful and felt welcome there. All as promoted and responses were totally on point. Location is comforting as well."
United States
Wendy W.
The price is AED 389
AED 1,013 total
includes taxes & fees
12 Sep - 13 Sep
2 bd/2bth near NMSU and Memorial Medical Center
TV

9. Cozy and Modern Home w/ King Bed and more!

Cozy and Modern Home w/ King Bed and more!
Las Cruces
9.8 out of 10, Exceptional, (30 reviews)
"We only stayed for a short visit but we had a great time. The Casita is deceptively big with plenty of room to relax. Comfy bed. The Wifi is excellent, too!"
United States
Megan H.
Cozy and Modern Home w/ King Bed and more!
Coffee/tea maker, fridge, microwave, stovetop

10. Modern New Mexico Loft in the heart of Las Cruces.

Modern New Mexico Loft in the heart of Las Cruces.
Las Cruces
Modern New Mexico Loft in the heart of Las Cruces.
Interior

11. Payne Place 1

Payne Place 1
Las Cruces
9.4 out of 10, Exceptional, (3 reviews)
"Clean, clean and clean! Great communication "
United States
Diana P.
Payne Place 1
Coffee/tea maker, fridge, microwave, oven

12. 2 king bds/2.5 bathrooms in the heart of Downtown

2 king bds/2.5 bathrooms in the heart of Downtown
Las Cruces
10.0 out of 10, Exceptional, (1 review)
"Great communication with host, perfect location centrally located, quiet neighborhood. Beautiful home!"
United States
Veronica M.
2 king bds/2.5 bathrooms in the heart of Downtown
Coffee/tea maker, fridge, microwave, oven

13. Historical 1940s Bungalow Near NMSU & Mesilla

Historical 1940s Bungalow Near NMSU & Mesilla
Las Cruces
Historical 1940s Bungalow Near NMSU & Mesilla
Coffee/tea maker, fridge, microwave, oven

14. 4 Bedroom Contemporary Model Home

4 Bedroom Contemporary Model Home
Las Cruces
9.0 out of 10, Wonderful, (36 reviews)
"Great stay. "
United States
Caroline M.
The price is AED 275
AED 924 total
includes taxes & fees
14 Sep - 15 Sep
4 Bedroom Contemporary Model Home
Exterior detail

15. Step into a newly renovated two-bed, one-bath haven in Mesilla Casita Conway #4

Step into a newly renovated two-bed, one-bath haven in Mesilla Casita Conway #4
Las Cruces
10.0 out of 10, Exceptional, (6 reviews)
"Lovely Casita, close to everything, yet has a country feel."
United States
Anonymous traveler
The price is AED 312
AED 633 total
includes taxes & fees
27 Sep - 28 Sep
Step into a newly renovated two-bed, one-bath haven in Mesilla Casita Conway #4
Dining

16. 2 bed with W/D, pets ok, 5 min to Farmers Market

2 bed with W/D, pets ok, 5 min to Farmers Market
Las Cruces
8.0 out of 10, Very Good, (1 review)
"Was a bit difficult to get into the house on first. Told the key pad numbers but didn't tell us to press KWIKSET. Then, to go leave, we didn't know that we just press KWICKSET. It would have been hpful to know all of that in the initial email. In addition, the key pad is at the front door NOT the back door. "
United States
Elaine
2 bed with W/D, pets ok, 5 min to Farmers Market
Terrace/patio

17. The Ritz serene spa sanctuary hot tub, mountain view, patio for the whole family

The Ritz serene spa sanctuary hot tub, mountain view, patio for the whole family
Las Cruces
9.6 out of 10, Exceptional, (52 reviews)
"Everything was as advertised, enjoyed our stay."
United States
Ashley M.
The Ritz serene spa sanctuary hot tub, mountain view, patio for the whole family
Interior

18. Charming 2 bedroom retreat at the end of the street equipped for any length stay

Charming 2 bedroom retreat at the end of the street equipped for any length stay
Las Cruces
10.0 out of 10, Exceptional, (13 reviews)
"Great little spot - close to town but super quiet neighborhood. Would def stay here again"
United States
Heather
Charming 2 bedroom retreat at the end of the street equipped for any length stay
Outdoor dining

19. 2 bd w/lrg fenced yard 3 mins from farmers market

2 bd w/lrg fenced yard 3 mins from farmers market
Las Cruces
10.0 out of 10, Exceptional, (2 reviews)
"Excellent little house with an amazing back yard!! This house has been completely refurbished with new furniture and appliances! If you’re looking for something with southwest style, you’ll appreciate the tile work in the kitchen and decorations throughout. The neighborhood has lots of culture with art and murals on walls and buildings. Make sure to go to the park nearby and visit The Bean coffee shop (got a red chile latte) and La Nueva Casita Café for a good local New Mexican meal. "
United States
Angelina M.
The price is AED 389
AED 943 total
includes taxes & fees
15 Sep - 16 Sep
2 bd w/lrg fenced yard 3 mins from farmers market
TV, fireplace

20. 2 bed/1 bath near NMSU, pets welcome

2 bed/1 bath near NMSU, pets welcome
Las Cruces
10.0 out of 10, Exceptional, (7 reviews)
"Host was responsive and worked with me to add an additional day after we arrived. Home is so clean and beautiful, was a great place for my family to relax and unwind halfway through our cross country drive. Would love to stay again when I’m in the area"
United States
Jennifer H.
2 bed/1 bath near NMSU, pets welcome
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mesilla Hotel Reviews

Days Inn by Wyndham Las Cruces

Days Inn by Wyndham Las Cruces

10/10 Excellent
"Clean rooms. Helpful staff. Breakfast was sufficient to start the day."
Aristides 1-night trip
Posted 4 hours ago
Days Inn by Wyndham Las Cruces