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Pick from Mytilene Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Frequently asked questions

Are you looking for a luxury hotel for your Mytilene vacation?
Mytilene has some interesting things to see and do including Port of Mytilene and Mytilini Castle, so you might want to take in the local sights during your visit.
What's the best time to vacation in Mytilene?
Planning for the weather is a good way to make your trip to Mytilene relaxing and enjoyable, especially when you’re splurging. The hottest months are usually August and July with an average temp of 77°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Mytilene is 34 inches.
What's there to see and do in Mytilene?
Take in the sights and attractions that Mytilene offers with a visit to Port of Mytilene, Mytilini Castle, and Roman Aqueduct at Moria. If you have a little extra time during your trip, you might want to make a stop at Museum of the Memorial of the Refugees of 1922 and Thermes Gera Hot Springs.