A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Find Resorts & Hotels with Spas in Mytilene

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mytilene Resorts & Hotels with Spas

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Mytilene hotels with a spa

A modern bathroom with a glass-enclosed shower, a bench, and a bed with towels.
A buffet with various food items including fruits, vegetables, and desserts.
A multi-story hotel with a central courtyard, balconies, and a rooftop terrace.
A hotel room with a large bed, a desk, a chair, a small refrigerator, a staircase, and a nightstand with a lamp.

1. Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
Lesvos
  • Escape to a boutique spa retreat with hot springs and massage therapy in the heart of Mytilene.
AED 450
AED 505 total
includes taxes & fees
9 Nov - 10 Nov
Theofilos Paradise Boutique Hotel
A person standing on a balcony overlooking a pool and a modern building with a clear view of the sea.
A person standing by a glass railing, holding a cup, with a view of the sea and mountains in the background.
A modern hotel with a swimming pool, outdoor seating, and a view of the sea.
A sauna with a glass enclosure, wooden benches, and a control panel.

2. Elysion Hotel

Elysion Hotel
Lesvos
  • Immerse in a rejuvenating Greek island escape with tennis courts, seasonal pools, and serene balconied rooms overlooking Lesvos.
AED 358
AED 454 total
includes taxes & fees
14 Oct - 15 Oct
Elysion Hotel
Two wicker chairs with cushions, a decorative plant, and a small round table with candles and a tray.
A resort with a pool, outdoor seating, and a view of the sea at dusk.
A dining area with a table and chairs, a vase with a flower, and a view of the sea through large windows.
A modern hotel room with a large bed, a dining area with a view of the sea, and a balcony with a table and chairs.

3. Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
Lesvos
  • Relax in a coastal spa haven with hydrotherapy, hot springs, and three indoor pools for ultimate rejuvenation.
AED 322
AED 415 total
includes taxes & fees
31 Oct - 1 Nov
Mythical Coast Wellness Retreat
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.
A woman sitting on a lounge chair under a large umbrella, with other lounge chairs and umbrellas in the background.
A residential area with a swimming pool, outdoor seating, and a view of the sea.
A modern house with a stone facade, a covered patio, and a swimming pool.

4. Elies Residences

Elies Residences
Lesvos
  • Relax in premium villas with spa treatments and outdoor pool in this serene getaway.
AED 361
AED 404 total
includes taxes & fees
21 Oct - 22 Oct
Elies Residences
A balcony with a view of the sea, a seating area, and a bed with pillows.
A modern outdoor seating area with a view of the sea, featuring a sofa, a wooden table, and a potted plant.
A balcony with a view of the sea, a white pitcher with plants, and a building with a red roof.
A modern bathroom with a large, round vessel sink, a mirror, and a potted plant.

5. Olive Green Studios and Apartments

Olive Green Studios and Apartments
Lesvos
  • Rejuvenating seaside retreat offers in-room massages and a tranquil garden sanctuary, perfect for a wellness escape by the beach.
AED 259
AED 292 total
includes taxes & fees
16 Oct - 17 Oct
Olive Green Studios and Apartments
View all properties

Choose what matters most at spa hotels in Mytilene

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Mytilene Hotel Reviews

Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel

8/10 Good
"Staff was nice. Large breakfast spread. Location is great."
Caroline 1-night trip
Posted 2 months ago
Theofilos Paradise Boutique Hotel

Frequently asked questions

Looking to vacation at a spa hotel in Mytilene?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the museums and churches in Mytilene—your cultural tour starts here. Enjoy the architecture and sea views during your vacation. Spa hotels are a great way to break out of your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Mytilene?
Mythical Coast Wellness Retreat is a top beach spa hotel featuring 5 restaurants, 5 bars, 3 indoor pools, and 5 cafes. Treat yourself to a facial, body scrub, or Swedish massage at Mythical Coast Spa. Another popular spa hotel in Mytilene is Theofilos Paradise Boutique Hotel.
How many spa hotels are there in Mytilene?
Among Expedia's 88 accommodation options in Mytilene, there are 2 spa hotels.
What's there to see and do in Mytilene?
When you're in Mytilene, enjoy exploring the sights and attractions here including Port of Mytilene, Mytilini Castle, and Roman Aqueduct at Moria. If you have a bit of extra time while you're in the area, you might want to check out Thermes Gera Hot Springs and St Hermogenes Charamida Lesvos.
What is a Mytilene spa hotel?
Spa hotels in Mytilene feature full on-site spas offering services like facials and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.