Poplar Bluff, MO Vacation Homes from AED 481

A sunset over a calm lake with red autumn leaves on the right.

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Our top choices for Poplar Bluff vacation homes

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Poplar Bluff

Brian

AED 1,044 total

includes taxes & fees

22 Jul - 23 Jul

Coffee/tea maker, fridge, microwave, oven

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

Dexter

AED 571 total

includes taxes & fees

28 Jul - 29 Jul

Get Away Acres 1/2 mile off highway 60 extra sanitized

Ellsinore

Anonymous traveler

AED 481 total

includes taxes & fees

22 Jul - 23 Jul

Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Wappapello

Shea E.

AED 970 total

includes taxes & fees

28 Jul - 29 Jul

Doc's Cottage - A-Frame in Piggott, AR

Piggott

Michael M.

AED 872 total

includes taxes & fees

11 Aug - 12 Aug

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter

AED 789 total

includes taxes & fees

26 Jul - 27 Jul

Hunting / Fishing Cabin at Lake Wappapello

Williamsville

AED 1,354 total

includes taxes & fees

22 Jul - 23 Jul

The Morning Glory - Country Cottage

Piggott

Justin C.

AED 936 total

includes taxes & fees

20 Aug - 21 Aug

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Top Poplar Bluff Hotel Reviews

Super 8 by Wyndham Poplar Bluff Missouri

10/10 Excellent

"The rooms was clean ,staff friendly and for breakfast they have waffle, cereals, toast bread, yogurt and coffee."

Holiday Inn Poplar Bluff by IHG

8/10 Good

"The hotel was clean and the staff were great. We did have an issue with the room door right at the start. The door would unlock, but not open! The desk clerk attempted to help, but the problem reoccurred. Maintenance came to look and said that that room door was quirky due t weather and showed us how to easily open it. No further issues with the door! The curtains in the room did not fully close and there was a lot of light from near-by businesses. The room's toilet was very slow to flush, and then it stopped up. I had to get a plunger to fix it. The toilets in the lobby's men's room did not flush. The breakfast choices were good and the service was great."

Home Sweet Home, Spacious Sunroom & Fun Deck!

10/10 Excellent

"It's always a pleasure staying at this house. Clean comfortable and convenient. My family has stayed here a half a dozen times and and will continue to stay here as long as it available on Vrbo. Thank you for providing a comfortable and well maintained property. Five stars I would get 10 if I could. Thank you"

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Poplar Bluff vacation homes

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

Get Away Acres 1/2 mile off highway 60 extra sanitized