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Compare 1,659 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Central Hotel Panama Casco Viejo

4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1001)
"Great location. Lovely lobby. Wonderful and abundant breakfast. Only drawback for us was our room -- it was a family room on the top floor and window was low, hard to see outside. Also a little loud from room next door. "
United States
Sara
Central Hotel Panama Casco Viejo

La Concordia Boutique Hotel

4.0 star property
Casco Viejo
9.6 out of 10, Exceptional, (194)
"The staff was very friendly and supportive. The room was spectacular! It was beautifully decorated and very clean. It was just a delight to stay in this lovely hotel!"
United States
Madelaine
La Concordia Boutique Hotel

Hotel Coral Suites

3.5 star property
Bella Vista
9.0 out of 10, Wonderful, (1006)
"Great place for the price. "
United States
Ryan
The price is AED 255
AED 280 total
includes taxes & fees
5 Dec - 6 Dec
Hotel Coral Suites

Waldorf Astoria Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1011)
"I loved everything about my stay "
United States
Stephanie
The price is AED 660
AED 726 total
includes taxes & fees
15 Dec - 16 Dec
Waldorf Astoria Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very Good, (1013)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is AED 611
AED 672 total
includes taxes & fees
16 Dec - 17 Dec
The Westin Playa Bonita Panama

TRYP by Wyndham Panamá Centro

3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1018)
"Staff was helpful, room was clean and I enjoyed my stay. "
United States
Lystra
The price is AED 293
AED 322 total
includes taxes & fees
2 Jan - 3 January 2026
TRYP by Wyndham Panamá Centro

Riande Aeropuerto Hotel & Casino

4.0 star property
Tocumen
8.6 out of 10, Excellent, (1856)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
The price is AED 459
AED 505 total
includes taxes & fees
4 Dec - 5 Dec
Riande Aeropuerto Hotel & Casino

Gamboa Rainforest Reserve

3.5 star property
Colon
7.8 out of 10, Good, (660)
"We had a lovely stay, the views and tranquility of the place was my favorite part."
United States
Rebecca
The price is AED 377
AED 423 total
includes taxes & fees
11 Dec - 12 Dec
Gamboa Rainforest Reserve

Principe Hotel and Suites

3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1590)
"Great hotel, location, food. Highly recommend the sushi restaurant next door.. One of the best ever. "
United States
Lakshmin
The price is AED 184
AED 202 total
includes taxes & fees
20 Dec - 21 Dec
Principe Hotel and Suites

Ramada Panama Centro Via Argentina

3.0 star property
Bella Vista
7.4 out of 10, Good, (267)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is AED 219
AED 240 total
includes taxes & fees
17 Dec - 18 Dec
Ramada Panama Centro Via Argentina

Aloft Panama

3.5 star property
San Francisco
8.8 out of 10, Excellent, (889)
"The staff was very friendly, rooms were clean and modern."
United States
Greg
The price is AED 406
AED 446 total
includes taxes & fees
7 Dec - 8 Dec
Aloft Panama

Novotel Panama City

4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1026)
"Room very clean, nice staffs and good location "
United States
Hayden
The price is AED 334
AED 367 total
includes taxes & fees
9 Dec - 10 Dec
Novotel Panama City

Bristol Panama, a Registry Collection Hotel

5.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1010)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is AED 661
AED 727 total
includes taxes & fees
19 Dec - 20 Dec
Bristol Panama, a Registry Collection Hotel

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (634)
"Beautiful property. Excellent lunch, fish tacos were amazing. "
United States
Marc
The price is AED 686
AED 755 total
includes taxes & fees
6 Dec - 7 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Hospedium Princess Hotel Panama

3.5 star property
Bella Vista
7.6 out of 10, Good, (689)
"The breakfast was great, I love the pool."
United States
Estefani
The price is AED 204
AED 224 total
includes taxes & fees
4 Dec - 5 Dec
Hospedium Princess Hotel Panama

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1018)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is AED 403
AED 443 total
includes taxes & fees
18 Dec - 19 Dec
Courtyard by Marriott Panama Metromall

Hotel La Compañía Casco Antiguo

4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (256)
"Many shops and restaurants nearby and the hotel is located in a beautiful area "
United States
Jerry
The price is AED 1,152
AED 1,267 total
includes taxes & fees
6 Dec - 7 Dec
Hotel La Compañía Casco Antiguo

Mahogany Suites

2.0 star property
Rousseau
10.0 out of 10, Exceptional, (1)
"Todo ok"
Colombia
Juan
The price is AED 334
AED 368 total
includes taxes & fees
26 Dec - 27 Dec
Mahogany Suites

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very Good, (1242)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
The price is AED 508
AED 559 total
includes taxes & fees
23 Dec - 24 Dec
Megapolis Hotel Panamá

Hampton by Hilton Panama

3.0 star property
Bella Vista
7.8 out of 10, Good, (1008)
"The hotel is good for the price , the lobby didn’t have any air conditioning,also the rooms where clean but needed to be updated , the breakfast buffet had multiple choices and it was very good . The hotel is in great location near walking distance to restaurants and stores . I will stay again. "
United States
Yusneilys amores
The price is AED 264
AED 291 total
includes taxes & fees
13 Dec - 14 Dec
Hampton by Hilton Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Clara attractions

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Santa Clara awaits: its natural setting, monuments, history, and more!

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Frequently asked questions

What's the best place for a stay in Santa Clara?
Located 15.8 mi (25.5 km) from the heart of Santa Clara, Hotel Riu Plaza Panama is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Las Americas Golden Tower Panama and Waldorf Astoria Panama. See all available top hotels, or vacation rentals in Santa Clara.
What's the top vacation rental in Santa Clara?
Panama View House – A Hilltop Retreat with Stunning Canal Views: This vacation home rental outside of Santa Clara has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Santa Clara.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about rescheduling or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What's the best place to stay near Culebra Cut?
Gamboa Rainforest Reserve is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers a marina and a full-service spa. It's located 2.9 mi (4.7 km) from Culebra Cut. Other good options within 5 miles include Canopy Bed & Breakfast and Casa en Gamboa al lado Canal de Panama.
What is staying in Santa Clara like?
Visitors can enjoy all that Santa Clara has to offer including its monuments. A top sight in the area is Albrook Shopping Mall. There are 1611 hotels and other accommodations in the surrounding area. Find out more about Santa Clara.
What is there to see in Santa Clara?
A favorite place to visit is Culebra Cut. Additionally, you'll find Albrook Shopping Mall in the area. Check out what more to see and do in Expedia's Santa Clara guide.
What's the seasonal weather like in Santa Clara?
The hottest months are usually April and March with an average temp of 79°F, while the coldest months are January and February with an average of 78°F. The rainiest months in Santa Clara are July, August, November, and October, with each month seeing an average of 11 inches of rainfall.

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