Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Santa Cruz de Toledo. The hottest months are usually August and September with an average temp of 53°F, while the coldest months are July and August with an average of 53°F. The rainiest months in Santa Cruz de Toledo are March, February, December, and January, with each month seeing an average of 10 inches of rainfall.