Santa Cruz Vacations

Book a Hotel + Flight together to unlock savings

Photo by Vivian Rennó
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    Better together

    Save up to AED 148 when you book a flight and hotel together*
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    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Santa Cruz Vacation Packages

Santa Cruz Hotel Deals

Santa Cruz Plaza

Santa Cruz Plaza

4 out of 5
Plaza De Armas 286, Santa Cruz, O'Higgins
Fully refundableReserve now, pay when you stay
The price is AED 433 per night from Jul 29 to Jul 30
AED 433
AED 433 total
29 Jul - 30 Jul
8.6/10 Excellent! (311 reviews)
"The hotel truly shines with its exceptional cleanliness and a refined design that takes inspiration from the Chilean countryside"

Reviewed on 6 June 2025

Santa Cruz Plaza
Hotel Vendimia Parador

Hotel Vendimia Parador

3 out of 5
Camino Los Boldos SN, Santa Cruz, O'Higgins
Fully refundableReserve now, pay when you stay
The price is AED 328 per night from Aug 8 to Aug 9
AED 328
AED 328 total
8 Aug - 9 Aug
9.4/10 Exceptional! (76 reviews)
"Great place for a weekend of wines and relax. My gf and I really enjoyed the facilities, good breakfast, owners provide great customer service."

Reviewed on 24 March 2025

Hotel Vendimia Parador
La Perla Hotel

La Perla Hotel

3.5 out of 5
El Rosal, Parcela 4, Lote A, Capellanía, Santa Cruz, O'Higgins
9/10 Wonderful! (94 reviews)
"Nice stay"

Reviewed on 13 April 2025

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La Perla Hotel
See all 52 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Cruz

Lapostolle Clos Apalta Winery

5/5(3 reviews)

You can enjoy a tasting or tour at Lapostolle Clos Apalta Winery during your travels to Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants.

Lapostolle Clos Apalta Winery

Casino Colchagua

Why not roll the dice with a visit to Casino Colchagua during your visit to Santa Cruz? While in this relaxing area, you can savor the wineries and restaurants.

Casino Colchagua

Colchagua Campo y Vino

5/5(1 review)

Enjoy an outing to Colchagua Campo y Vino during your stay in Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants.

Colchagua Campo y Vino

Frequently asked questions

How much does a Santa Cruz vacation package cost?
You can grab a vacation package to this destination on Expedia. However, how much your vacation to Santa Cruz costs will depend on the season, hotel choice and length of stay.
What are the cheapest months to go to Santa Cruz?
You can usually find reduced prices and better availability in May, July and September. Browse our cheap Santa Cruz vacation packages and you could get some great off-season discounts.
How to find the best Santa Cruz package deals?
Start your search for a Santa Cruz package deal by entering your destination and preferred travel dates under our "Packages" tab. Then add some filters, like "Popular locations" and "Amenities," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with huge savings. If you don't find the ideal Santa Cruz package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Santa Cruz escape underway.
Is it cheaper to book a Santa Cruz vacation as a package?
You can enjoy significant savings on your Santa Cruz getaway by booking a tailored vacation package. Check the "Package" heading, then select your destination and travel dates to browse some great hotel prices and airfares. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may land a better deal.
When to book a vacation package to Santa Cruz?
Enjoy amazing discounts by booking your flights ahead of time with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for an impromptu Santa Cruz trip.
How to plan a trip to Santa Cruz?

  1. Choose when to get away: Check your schedule and pack your bags. Your favorite season and the available activities will also help you decide when to vacation in Santa Cruz.
  2. Figure out your budget: Make sure you have enough money to pay for everything from food and transportation to airfares and activities. Your accommodations will probably be the largest expense during your trip to Santa Cruz.
  3. Work out your trip length: Consider how much time you'd like to spend discovering Santa Cruz. Plan your itinerary so you can get to all the activities and attractions you're interested in at a leisurely pace.
  4. Combine your accommodations and airfare: Once you've nailed down your trip dates and duration, book the perfect Santa Cruz vacation package for you.