Santa Fe Vacations

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  • Plan, book, travel with confidence

  • Better together

    Save up to AED 148 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Find the Best Santa Fe Vacation Packages

Santa Fe Hotel Deals

La Qhia Eco Retreat

La Qhia Eco Retreat

2.5 out of 5
Barriada el Cerro A 100 Mts De Santa Fe Veraguas
7.8/10 Good! (18 reviews)
Nice stay in Santa Fe
Our room had some drawbacks, like many gaps between the roof and walls that enable insects to go inside, but we used our own mosquito net and we were safe to sleep quietly. The second night ants invaded our room, we were offered to be moved to another room, but we were ok with the solution to spray ...

Reviewed on 17 March 2025

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La Qhia Eco Retreat
Hotel Anachoreo

Hotel Anachoreo

3 out of 5
Calle Chinita Santa Fe Veraguas Province
Fully refundableReserve now, pay when you stay
9.4/10 Exceptional! (36 reviews)
Wonderful location with absolutely breathing taking views! Room was quite large with a seating area. Beds comfortable but could use slightly better pillows.

Reviewed on 14 November 2025

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Hotel Anachoreo
Cabana Vergara Santa Fe

Cabana Vergara Santa Fe

2 out of 5
Provincia de Veraguas, Panama Panama
The price is AED 367 per night from Dec 31 to Jan 1
AED 367
AED 588 total
31 Dec - 1 January 2026
includes taxes & fees
Cabana Vergara Santa Fe
See all 15 properties in Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Fe

Alto de Piedra Waterfall

Commune with nature and explore the great outdoors at Alto de Piedra Waterfall during your travels in Santa Fe. While you're in the area, wander around the natural setting.

Alto de Piedra Waterfall

Town Square

You can find out about the history of Santa Fe with a stop at Town Square. Amble around the area's riverfront or visit its churches.

Town Square

Quebrada Las Trancas Spa

Commune with nature and explore the great outdoors at Quebrada Las Trancas Spa during your travels in Santa Fe. While you're in the area, wander around the natural setting.

Quebrada Las Trancas Spa

Frequently asked questions

How do I find cheap flights to Santa Fe that have flexible change policies?
We understand that travel schedules can change from one day to the next, so reserving a flexible ticket with Expedia is always a clever idea. Just check the "No change fee" box underneath the "Flexible change policies" filter. Your low-cost, flexible flight to Santa Fe is only a few clicks away.
Which airlines fly to Santa Fe?
With a good range of airlines operating flights into or near Santa Fe, you have plenty of choice:

  • Copa Airlines - 915 flights to or near Santa Fe each month, including 915 flights to Tocumen Intl. Airport (PTY) per month.
  • United Airlines - 152 flights to or near Santa Fe each month, including 152 flights to Tocumen Intl. Airport (PTY) per month.
  • American Airlines - 30 flights to or near Santa Fe each month, including 30 flights to Tocumen Intl. Airport (PTY) per month.

How can I find cheap tickets to Santa Fe?
One of the best ways to nab cheap tickets to Santa Fe is to be flexible with your travel dates. Search for your flights, then click "flexible dates" at the top of your results. It will reveal the cheapest prices for nearby days. The best price for a flight to Santa Fe in the last seven days was . Booking well ahead of time will usually help you get an even bigger bargain.
How much is a flight to Santa Fe?
You could have nabbed a round-trip ticket to Santa Fe from anywhere between and in the last seven days. For one-way journeys departing from (), the lowest amount paid during this period was just .
What are the most popular airports to fly into in Santa Fe?
The main entryway to Santa Fe, about 1,097 flights taxi into Tocumen Intl. Airport (PTY) each month. Look for a great deal, reserve your fare and prepare to experience this renowned region.
When is the cheapest time to fly to Santa Fe?
If you'd prefer to spend your vacation dollars on having fun in Santa Fe rather than on your trip there, depart earlier in the week. The most economical day to fly is generally Tuesday, with Monday running a close second. With many folks keeping their travel to weekends, Saturday typically has the costliest fares.
How much is a plane ticket to Santa Fe?
Plane tickets to Santa Fe varied from to in the last seven days. Generally, the sooner you make a reservation, the better the price.
What months are the cheapest to book a flight to Santa Fe?
The top month to book low-cost airfares to Santa Fe is February. Remember that in the USA, the most expensive time to secure a ticket is the busy month of December.
How long is a flight to Santa Fe?
The time it takes will all depend on the place you're traveling from. This list of the most popular routes to Santa Fe will give you a better idea of what to expect:

  • Miami, FL (MIA-Miami Intl.) to Tocumen Intl. Airport (PTY) - 3 hours and 13 minutes
  • Orlando, FL (MCO-Orlando Intl.) to Tocumen Intl. Airport (PTY) - 3 hours and 30 minutes
  • Los Angeles, CA (LAX-Los Angeles Intl.) to Tocumen Intl. Airport (PTY) - 6 hours and 23 minutes