The Best Business Hotels in Santee, SC from AED 231 in 2026 | Expedia

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Check availability on Santee Business Hotels

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16 Oct - 18 Oct

Our top choices for Santee business-friendly hotels

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A gym with treadmills, weight machines, and a wall of dumbbells.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

1. Hampton Inn Santee-I-95

Santee

United States

sandra

AED 404

AED 449 total

includes taxes & fees

11 Oct - 12 Oct

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

2. Fairfield Inn & Suites by Marriott Santee

Santee

United States

Melissa

AED 509

AED 565 total

includes taxes & fees

11 Oct - 12 Oct

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

A modern lobby with a blue sofa, teal chairs, and a wooden table.

3. Tru By Hilton Santee

Santee

United States

Connor

AED 372

AED 412 total

includes taxes & fees

11 Oct - 12 Oct

A hotel entrance with a sign reading "Best Western PLISS."

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

4. Best Western Plus Santee Inn

Santee

United States

Johnny

AED 481

AED 534 total

includes taxes & fees

14 Oct - 15 Oct

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

5. Baymont by Wyndham Santee

Santee

United States

Cindy

AED 294

AED 326 total

includes taxes & fees

5 Oct - 6 Oct

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

6. Comfort Inn & Suites Santee

Santee

United States

santa

AED 388

AED 431 total

includes taxes & fees

1 Nov - 2 Nov

A water park with a pool, slides, and umbrellas.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

A modern lounge area with seating, tables, and a fireplace.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

7. Holiday Inn Santee by IHG

Santee

United States

roderick

AED 378

AED 420 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

A kitchen with a countertop, cabinets, a microwave, and a sink.

8. Travelodge by Wyndham Santee

Santee

United States

Joshua

AED 235

AED 261 total

includes taxes & fees

18 Oct - 19 Oct

View all properties

Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good

"Property was great for quick overnight stay off of 95 withy my dog. Walking distance to Cracker Barrel. I would definitely stay here again"

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

8/10 Good

"Good cleaning room, good ac"