An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Find Business Hotels in Santee, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee Business Hotels

Tonight
3 Oct - 4 Oct
Tomorrow
4 Oct - 5 Oct
Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

Our top choices for Santee business-friendly hotels

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.
A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.
A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.
A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

1. Baymont by Wyndham Santee

Baymont by Wyndham Santee
Santee
United States
Cindy
AED 275
AED 306 total
includes taxes & fees
4 Oct - 5 Oct
Baymont by Wyndham Santee
A hotel entrance with a sign reading "Best Western PLISS."
A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.
A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.
A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

2. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
United States
Johnny
AED 481
AED 534 total
includes taxes & fees
14 Oct - 15 Oct
Best Western Plus Santee Inn
A dining area with multiple tables and chairs, a ceiling fan, and large windows.
A two-story building with a beige facade, large windows, and a central entrance.
A reception area with a marble counter, a television, and a logo for 'Superstart breakfast'.
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

3. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
Santee
United States
William
AED 234
AED 260 total
includes taxes & fees
11 Oct - 12 Oct
Super 8 by Wyndham Santee/I-95
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.
A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.
A living room with a brown sofa set, a wooden coffee table, and a chandelier.
A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

4. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
Santee
United States
Mark
AED 200
AED 242 total
includes taxes & fees
25 Oct - 26 Oct
Quality Inn & Suites Santee I-95
A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.
A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'
A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.
A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

5. Red Roof Inn Santee

Red Roof Inn Santee
Santee
United States
Tiffany
AED 231
AED 257 total
includes taxes & fees
6 Oct - 7 Oct
Red Roof Inn Santee
Lobby
A gym with treadmills, an elliptical, dumbbells, and a bench.
A conference room with round tables, black chairs, and white tablecloths.
A hotel room with two beds, a desk, and a chair.

6. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
Santee
United States
Stevenson
AED 316
AED 351 total
includes taxes & fees
4 Oct - 5 Oct
Ramada by Wyndham Santee I-95
A two-story building with a sign reading "PachTree Inn".
A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.
A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.
A reception desk with a clock, framed certificates, and a window with a view.

7. Peach Tree Inn

Peach Tree Inn
St. George
United States
Linda
AED 237
AED 256 total
includes taxes & fees
5 Oct - 6 Oct
Peach Tree Inn
A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.
A corner market with a refrigerator stocked with beverages and snacks.
A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.
A workspace with two desks, each with a computer monitor, keyboard, and chair.

8. Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
Orangeburg
United States
Percy
AED 372
AED 412 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn by Marriott Orangeburg
A self-service kiosk with a beverage cooler, microwave, and various food items.
A breakfast counter with a sign reading 'TOP IT BREAKFAST,' a coffee machine, a yogurt dispenser, and various food items.
A modern hotel lobby with a reception desk, blue and gray seating, a TV screen, and unique pendant lighting.
A pool table in a room with a colorful mural, chairs, and a sofa.

9. Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
Orangeburg
United States
Deborah
AED 434
AED 482 total
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Orangeburg
A hotel room with two beds, a desk, a chair, and a mirror.
A living room with a sofa, armchair, coffee table, and a flat-screen TV mounted on the wall.
A modern cafe with a stone backsplash, wooden cabinets, and yellow chairs.
A wooden pergola with a bench, a well-maintained lawn, and a parking area with buildings in the background.

10. SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning
Manning
United States
Bruce
AED 349
AED 387 total
includes taxes & fees
4 Oct - 5 Oct
SureStay Hotel by Best Western Manning
View all properties

Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good
"Property was great for quick overnight stay off of 95 withy my dog. Walking distance to Cracker Barrel. I would definitely stay here again"
Patricia 1-night trip
Posted 1 day ago
Baymont by Wyndham Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

8/10 Good
"Good cleaning room, good ac"
Benjamin 2-night trip
Posted 4 days ago
Travelodge by Wyndham Santee