An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Find Business Hotels in Santee, SC

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Check availability on Santee Business Hotels

Tonight
6 Oct - 7 Oct
Tomorrow
7 Oct - 8 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Santee business-friendly hotels

A hotel entrance with a sign reading "Best Western PLISS."
A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.
A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.
A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

1. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
United States
Johnny
AED 481
AED 534 total
includes taxes & fees
14 Oct - 15 Oct
Best Western Plus Santee Inn
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.
A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.
A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.
A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

2. Baymont by Wyndham Santee

Baymont by Wyndham Santee
Santee
United States
Cindy
AED 294
AED 326 total
includes taxes & fees
7 Oct - 8 Oct
Baymont by Wyndham Santee
A water park with a pool, slides, and umbrellas.
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.
A reception desk with a wooden panel backdrop and a neon sign.
A modern lounge area with seating, tables, and a fireplace.

3. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
Santee
United States
roderick
AED 400
AED 444 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Santee by IHG
A dining area with multiple tables and chairs, a ceiling fan, and large windows.
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.
A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.
A reception area with a marble counter, a television, and a logo for 'Superstart breakfast'.

4. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
Santee
United States
William
AED 234
AED 260 total
includes taxes & fees
14 Oct - 15 Oct
Super 8 by Wyndham Santee/I-95
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.
A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.
A living room with a brown sofa set, a wooden coffee table, and a chandelier.
A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

5. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
Santee
United States
Mark
AED 200
AED 240 total
includes taxes & fees
26 Oct - 27 Oct
Quality Inn & Suites Santee I-95
A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.
A hotel room with a bed, bedside tables, a desk, a mirror, and a wall-mounted TV.
A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'
A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

6. Red Roof Inn Santee

Red Roof Inn Santee
Santee
United States
Tiffany
AED 231
AED 257 total
includes taxes & fees
11 Oct - 12 Oct
Red Roof Inn Santee
Lobby
A hotel room with two beds, a desk, and a chair.
A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.
A conference room with round tables, black chairs, and white tablecloths.

7. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
Santee
United States
Stevenson
AED 323
AED 359 total
includes taxes & fees
19 Oct - 20 Oct
Ramada by Wyndham Santee I-95
A two-story building with a sign reading "PachTree Inn".
A compact hotel room with a kitchenette, a television, a desk, and a chair.
A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.
A reception desk with a clock, framed certificates, and a window with a view.

8. Peach Tree Inn

Peach Tree Inn
St. George
United States
Linda
AED 214
AED 231 total
includes taxes & fees
8 Oct - 9 Oct
Peach Tree Inn
A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.
A workspace with two desks, each with a computer monitor, keyboard, and chair.
A corner market with a refrigerator stocked with beverages and snacks.
A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.

9. Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
Orangeburg
United States
Julie
AED 372
AED 412 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn by Marriott Orangeburg
A self-service kiosk with a beverage cooler, microwave, and various food items.
A breakfast counter with a sign reading 'TOP IT BREAKFAST,' a coffee machine, a yogurt dispenser, and various food items.
A modern hotel lobby with a reception desk, blue and gray seating, a TV screen, and unique pendant lighting.
A modern interior with a dining area, seating arrangements, and a reception desk.

10. Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
Orangeburg
United States
Deborah
AED 434
AED 482 total
includes taxes & fees
19 Oct - 20 Oct
Tru by Hilton Orangeburg
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Top Santee Hotel Reviews

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

10/10 Excellent
"Extremely good value for money, room was clean, tidy and very well appointed. Will absolutely come here again."
Robert 1-night trip
Posted 3 hours ago
Travelodge by Wyndham Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good
"Clean, comfortable and friendly."
Dorothy 1-night trip
Posted 1 day ago
Baymont by Wyndham Santee