An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Find Business Hotels in Santee, SC

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Check availability on Santee Business Hotels

Tonight
21 Oct - 22 Oct
Tomorrow
22 Oct - 23 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Santee business-friendly hotels

A hotel entrance with a sign reading "Best Western PLISS."
A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.
A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.
A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

1. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
United States
Johnny
AED 481
AED 534 total
includes taxes & fees
18 Nov - 19 Nov
Best Western Plus Santee Inn
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.
A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.
A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.
A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

2. Baymont by Wyndham Santee

Baymont by Wyndham Santee
Santee
United States
Cindy
AED 294
AED 326 total
includes taxes & fees
25 Oct - 26 Oct
Baymont by Wyndham Santee
A water park with a pool, slides, and umbrellas.
A modern lounge area with seating, tables, and a fireplace.
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.
A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

3. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
Santee
United States
Traci
AED 404
AED 448 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Santee by IHG
A dining area with multiple tables and chairs, a ceiling fan, and large windows.
A two-story building with a beige facade, large windows, and a central entrance.
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.
A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

4. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
Santee
United States
William
AED 234
AED 260 total
includes taxes & fees
27 Oct - 28 Oct
Super 8 by Wyndham Santee/I-95
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.
A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.
A living room with a brown sofa set, a wooden coffee table, and a chandelier.
A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

5. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
Santee
United States
Louis
AED 200
AED 240 total
includes taxes & fees
10 Nov - 11 Nov
Quality Inn & Suites Santee I-95
A two-story building with a flat roof and a central entrance.
A kitchen with a long countertop, various appliances, and cabinets.
A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.
A hotel lobby with a reception desk, a dining area with tables and chairs, and a view of the outside.

6. Red Roof Inn Santee

Red Roof Inn Santee
Santee
United States
Sharyn
AED 231
AED 257 total
includes taxes & fees
25 Oct - 26 Oct
Red Roof Inn Santee
Lobby
Room
A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.
A gym with treadmills, an elliptical, dumbbells, and a bench.

7. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
Santee
United States
Stevenson
AED 291
AED 323 total
includes taxes & fees
27 Oct - 28 Oct
Ramada by Wyndham Santee I-95
A two-story building with a sign reading "PachTree Inn".
A reception desk with a clock, framed certificates, and a window with a view.
A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.
A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.

8. Peach Tree Inn

Peach Tree Inn
St. George
United States
Linda
AED 225
AED 243 total
includes taxes & fees
1 Nov - 2 Nov
Peach Tree Inn
A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.
A corner market with a refrigerator stocked with beverages and snacks.
A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.
A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.

9. Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
Orangeburg
United States
Julie
AED 372
AED 412 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn by Marriott Orangeburg
A hotel room with two beds, a desk, a chair, and a mirror.
A two-story building with a sign indicating it is a hotel.
A modern cafe with a stone backsplash, wooden cabinets, and yellow chairs.
A living room with a sofa, armchair, coffee table, and a flat-screen TV mounted on the wall.

10. SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning
Manning
United States
Bruce
AED 311
AED 345 total
includes taxes & fees
8 Nov - 9 Nov
SureStay Hotel by Best Western Manning
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Top Santee Hotel Reviews

Super 8 by Wyndham, Orangeburg

Super 8 by Wyndham, Orangeburg

10/10 Excellent
"Room was good. AC unit was modern and functioned well."
Robin 1-night trip
Posted 1 hour ago
Super 8 by Wyndham, Orangeburg
Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
"I have stayed here several times traveling to and from Florida and Virginia. The staff has always been courteous and helpful. My room was always very clean. I would highly recommend a stay here.."
Lee Ann 1-night trip
Posted 19 hours ago
Baymont by Wyndham Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

10/10 Excellent
"Excellent place to visit and friendly people"
Raymond 1-night trip
Posted 4 days ago
Hampton Inn Santee-I-95