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Find Business Hotels in Santee, SC

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Check availability on Santee Business Hotels

Tonight
15 Oct - 16 Oct
Tomorrow
16 Oct - 17 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Santee business-friendly hotels

A hotel entrance with a sign reading "Best Western PLISS."
A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.
A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.
A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

1. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
United States
Johnny
AED 512
AED 568 total
includes taxes & fees
21 Oct - 22 Oct
Best Western Plus Santee Inn
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.
A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.
A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.
A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

2. Baymont by Wyndham Santee

Baymont by Wyndham Santee
Santee
United States
Cindy
AED 294
AED 326 total
includes taxes & fees
18 Oct - 19 Oct
Baymont by Wyndham Santee
A water park with a pool, slides, and umbrellas.
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.
A reception desk with a wooden panel backdrop and a neon sign.
A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

3. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
Santee
United States
roderick
AED 367
AED 408 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Santee by IHG
A dining area with multiple tables and chairs, a ceiling fan, and large windows.
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.
A two-story building with a beige facade, large windows, and a central entrance.
A reception area with a marble counter, a television, and a logo for 'Superstart breakfast'.

4. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
Santee
United States
William
AED 234
AED 260 total
includes taxes & fees
21 Oct - 22 Oct
Super 8 by Wyndham Santee/I-95
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.
A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.
A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.
A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

5. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
Santee
United States
Doug
AED 200
AED 240 total
includes taxes & fees
4 Nov - 5 Nov
Quality Inn & Suites Santee I-95
A two-story building with a flat roof and a central entrance.
A spacious kitchen with a dining area, wooden flooring, and a Red Roof Inn sign.
A hotel room with a large bed, a desk, a television, and a door.
A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

6. Red Roof Inn Santee

Red Roof Inn Santee
Santee
United States
Tiffany
AED 231
AED 257 total
includes taxes & fees
18 Oct - 19 Oct
Red Roof Inn Santee
Lobby
A conference room with round tables, black chairs, and white tablecloths.
A gym with treadmills, an elliptical, dumbbells, and a bench.
Room

7. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
Santee
United States
Stevenson
AED 291
AED 323 total
includes taxes & fees
19 Oct - 20 Oct
Ramada by Wyndham Santee I-95
A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.
A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.
A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.
A workspace with two desks, each with a computer monitor, keyboard, and chair.

8. Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
Orangeburg
United States
Julie
AED 372
AED 412 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn by Marriott Orangeburg
A two-story building with a sign reading "PachTree Inn".
A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.
A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.
A reception desk with a clock, framed certificates, and a window with a view.

9. Peach Tree Inn

Peach Tree Inn
St. George
United States
Linda
AED 214
AED 231 total
includes taxes & fees
18 Oct - 19 Oct
Peach Tree Inn
Exterior
A modern hotel building with a 'tru by Hilton' sign, multiple windows, and a parking lot.
A modern cafe with a long communal table, individual seating, and a large window.
A modern lounge area with seating, tables, and decorative lighting.

10. Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
Orangeburg
United States
Belinda
AED 403
AED 447 total
includes taxes & fees
1 Nov - 2 Nov
Tru by Hilton Orangeburg
View all properties

Top Santee Hotel Reviews

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

10/10 Excellent
"Staff is friendly and efficient!! Great place that we always come back to when heading on 95."
Stacey 1-night trip
Posted 10 hours ago
Holiday Inn Santee by IHG
Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
":)"
Robert 1-night trip
Posted 4 days ago
Baymont by Wyndham Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

10/10 Excellent
"Nice bed, water was very hot which is nice, and satellite TV with tons of channels."
Robert 1-night trip
Posted 4 days ago
Travelodge by Wyndham Santee
Super 8 by Wyndham, Orangeburg

Super 8 by Wyndham, Orangeburg

10/10 Excellent
"We stayed one night but it was clean, the bed was comfortable, and the breakfast provided was very good."
Melissa 1-night trip
Posted 6 days ago
Super 8 by Wyndham, Orangeburg