Find Luxury Hotels in Santee, SC
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Pick from 5 Santee Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
8.0 out of 10, Very Good, (839)
The price is AED 457
AED 507 total
includes taxes & fees
4 Jun - 5 Jun
Baymont by Wyndham Santee
Baymont by Wyndham Santee
7.8 out of 10, Good, (1315)
The price is AED 275
AED 306 total
includes taxes & fees
4 Jun - 5 Jun
Red Roof Inn Santee
Red Roof Inn Santee
6.4 out of 10, (556)
The price is AED 257
AED 285 total
includes taxes & fees
26 May - 27 May
Econo Lodge
Econo Lodge
6.4 out of 10, (302)
The price is AED 240
AED 266 total
includes taxes & fees
18 Jun - 19 Jun
Rodeway Inn Santee I-95
Rodeway Inn Santee I-95
6.2 out of 10, (498)
The price is AED 330
AED 367 total
includes taxes & fees
25 May - 26 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent reviews of Santee hotelsExpedia verified reviews
5/5 Excellent
"Stopped in after a long day of work and driving. Perfect for what I needed. Shower, clean bed and quiet. Will stay again next time I pass through."
A verified traveler stayed at SureStay Hotel by Best Western Manning
Posted 2 days ago
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More Hotel Options in Santee
- Adventure Hotels (3)
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- Cheap Hotels (7)
- Family Hotels (10)
- Golf Hotels (5)
- Hotel with a Concierge (1)
- Hotels with Bars (6)
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- Hotels with Hot Tubs (3)
- Hotels with WiFi (13)
- Hotels with a Pool (10)
- Hotels with an Indoor Pool (1)
- Hotels with smoking rooms (1)
- Pet-friendly Hotels (10)
- Resorts & Hotels with Spas (2)
- Shopping Hotels (11)
More Accommodation Types in Santee
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- Resorts in South Carolina (1,024)
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Hotels near popular Santee Attractions
- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee Outlets
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near Lake Marion
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Wyboo Golf Club
- Hotels near Edisto Memorial Gardens
Santee Hotels by Star Rating
Explore more hotels
- Super 8 by Wyndham Santee
- Two Palms Lakehouse in Santee Just minutes from I95
- Rodeway Inn Santee I-95
- Executive 2 BR/2 BA Lakefront Corner Suite Condo
- Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
- Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
- Wyndham Vacation Resorts Lake Marion
- SureStay Hotel by Best Western Manning
- Days Inn by Wyndham St George
- Country Inn & Suites by Radisson, Orangeburg, SC
- Tru by Hilton Orangeburg
- Fairfield Inn by Marriott Orangeburg
- Travelodge by Wyndham Orangeburg
- SpringHill Suites by Marriott Orangeburg
- Holiday Inn Express & Suites Orangeburg
- Hampton Inn Manning
- Red Roof Inn St George, SC
- Baymont by Wyndham Manning
- Hampton Inn & Suites Orangeburg
- Baymont by Wyndham Orangeburg North