Find Resorts & Hotels with Spas in Santee, SC

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Santee Resorts & Hotels with Spas

This weekend
Next weekend

Top Santee Resorts & Hotels with Spas

We don't have any properties that match your exact search
See all properties in Santee

Recommended hotels in Santee

Tru By Hilton Santee

2.5 star property
9.2 out of 10, Wonderful, (552)
"Great stay"
The price is AED 404
AED 448 total
includes taxes & fees
12 Oct - 13 Oct
Tru By Hilton Santee

Fairfield Inn by Marriott Orangeburg

2.5 star property
8.4 out of 10, Very Good, (648)
"Staff were very friendly, room was nice and clean and the hot breakfast was amazing!"
The price is AED 309
AED 342 total
includes taxes & fees
6 Oct - 7 Oct
Fairfield Inn by Marriott Orangeburg

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1345)
"A nice location, plenty of parking, nice that breakfast was included. "
The price is AED 275
AED 306 total
includes taxes & fees
5 Oct - 6 Oct
Baymont by Wyndham Santee

Best Inn of Manning

2.5 star property
The price is AED 272
AED 302 total
includes taxes & fees
12 Oct - 13 Oct
Best Inn of Manning

SureStay Hotel by Best Western Manning

2.5 star property
8.6 out of 10, Excellent, (1000)
"People were fantasticly friendly. "
The price is AED 419
AED 465 total
includes taxes & fees
5 Oct - 6 Oct
SureStay Hotel by Best Western Manning

Hampton Inn Santee-I-95

2.5 star property
9.6 out of 10, Exceptional, (1000)
"Staff was very friendly and accommodating. "
The price is AED 495
AED 549 total
includes taxes & fees
2 Nov - 3 Nov
Hampton Inn Santee-I-95

Fairfield Inn & Suites by Marriott Santee

2.5 star property
9.8 out of 10, Exceptional, (1000)
"Great stay for a quick weekend getaway!"
The price is AED 492
AED 546 total
includes taxes & fees
12 Oct - 13 Oct
Fairfield Inn & Suites by Marriott Santee

Comfort Inn & Suites Santee

2.5 star property
8.0 out of 10, Very Good, (1000)
"Great place to stay."
The price is AED 387
AED 430 total
includes taxes & fees
12 Oct - 13 Oct
Comfort Inn & Suites Santee

Best Western Plus Santee Inn

2.5 star property
8.8 out of 10, Excellent, (1000)
"We really enjoyed our stay and will be back!"
The price is AED 431
AED 478 total
includes taxes & fees
12 Oct - 13 Oct
Best Western Plus Santee Inn

Holiday Inn Santee by IHG

3.0 star property
8.2 out of 10, Very Good, (950)
"Nice clean, great location "
The price is AED 433
AED 481 total
includes taxes & fees
2 Nov - 3 Nov
Holiday Inn Santee by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Santee Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Santee?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Travelers recommend the gourmet restaurants in Santee. Be sure to enjoy activities like fishing and golfing during your stay. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Santee?
Enjoy all that Santee has to offer when you visit Santee Cooper Country Club, Santee National Golf Club, and Santee State Park. If you have a bit of extra time while you're in the area, you might want to check out Lake Marion and Santee Town Hall.
What is a Santee spa hotel?
Spa hotels in Santee provide lodging and have an on-site spa offering services such as facials and beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.