Weather is only one factor, but it can really affect your travel plans, especially when you are planning a longer stay in Santo Tomé. The hottest months are usually January and February with an average temp of 78°F, while the coldest months are July and June with an average of 60°F. The rainiest months in Santo Tomé are October, November, March, and January, with each month seeing an average of 8 inches of rainfall.