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10 Nov - 11 Nov
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11 Nov - 12 Nov
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13 Nov - 15 Nov
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Our top choices for Science Center of Iowa hotels

A spacious lobby with high ceilings, large windows, and a chandelier.

1. Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton
4.5 star property
Western Gateway, 0.8 km from Science Center of Iowa
9.6 out of 10, Exceptional, (1,422 reviews)
"Love the Bar and Restaurant also the Rooms were perfect with great staff in all locations."
United States
Christopher
The price is AEDĀ 458
AEDĀ 513 total
includes taxes & fees
15 Nov - 16 Nov
Hotel Fort Des Moines, Curio Collection by Hilton
A luxurious living room with a stone fireplace, a large mirror, and two blue armchairs.

2. Des Lux Hotel

Des Lux Hotel
3.5 star property
Court District, 0.7 km from Science Center of Iowa
9.6 out of 10, Exceptional, (1,119 reviews)
"Great place to stay!"
United States
Bryan
The price is AEDĀ 592
AEDĀ 663 total
includes taxes & fees
11 Nov - 12 Nov
Des Lux Hotel
A modern bar with wooden shelves and a long counter.

3. Surety Hotel, Autograph Collection

Surety Hotel, Autograph Collection
4.0 star property
Court District, 0.5 km from Science Center of Iowa
9.4 out of 10, Exceptional, (1,002 reviews)
"Conveniently located well appointed property. Staff were very helpful."
Australia
Brett
The price is AEDĀ 558
AEDĀ 625 total
includes taxes & fees
26 Nov - 27 Nov
Surety Hotel, Autograph Collection
A modern building with a sign that reads 'Staybridge Suites.' It features a mix of glass and brick facades, large windows, and a flat roof.

4. Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG
3.0 star property
Historic East Village, 0.8 km from Science Center of Iowa
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean great stay!!!"
United States
Emily
The price is AEDĀ 356
AEDĀ 399 total
includes taxes & fees
7 Dec - 8 Dec
Staybridge Suites Des Moines Downtown by IHG
An indoor swimming pool with clear water, a no diving sign, and a pool ladder.

5. Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG
2.5 star property
Downtown Des Moines, 0.8 km from Science Center of Iowa
9.2 out of 10, Wonderful, (1,006 reviews)
"Very nice hotel. Staff was very friendly. And the room was very clean and comfy."
United States
CaSandra
The price is AEDĀ 389
AEDĀ 436 total
includes taxes & fees
8 Dec - 9 Dec
Holiday Inn Express & Suites Des Moines Downtown by IHG
A modern lobby with a central bar area, seating arrangements, and a distinctive ceiling design.

6. Hilton Des Moines Downtown

Hilton Des Moines Downtown
3.5 star property
Downtown Des Moines, 0.9 km from Science Center of Iowa
9.0 out of 10, Wonderful, (1,005 reviews)
"It was my second time staying and will definitely always choose this hotel. It was a very pleasant, beautiful, and the perfect spot downtown. Staff were also great!"
United States
Leanna
The price is AEDĀ 509
AEDĀ 587 total
includes taxes & fees
23 Nov - 24 Nov
Hilton Des Moines Downtown
An outdoor patio area with tables and chairs, a fire pit, and string lights.

7. Fairfield Inn & Suites by Marriott Des Moines Downtown

Fairfield Inn & Suites by Marriott Des Moines Downtown
4.0 star property
Downtown Des Moines, 1.2 km from Science Center of Iowa
9.0 out of 10, Wonderful, (543 reviews)
"Great location to all of downtown"
United States
CINDY
The price is AEDĀ 417
AEDĀ 467 total
includes taxes & fees
16 Nov - 17 Nov
Fairfield Inn & Suites by Marriott Des Moines Downtown
A modern kitchen with a central island, bar stools, stainless steel appliances, and pendant lighting.

8. Kasa Downtown Des Moines

Kasa Downtown Des Moines
4.0 star property
Downtown Des Moines, 0.8 km from Science Center of Iowa
9.0 out of 10, Wonderful, (129 reviews)
"Cute little area, close to downtown. Parking is close - do not risk parking on the road!"
United States
Courtnie
The price is AEDĀ 215
AEDĀ 487 total
includes taxes & fees
28 Nov - 29 Nov
Kasa Downtown Des Moines
A modern hotel with a prominent 'AC' sign, large windows, and a street view with traffic lights and a crosswalk.

9. AC Hotel Des Moines East Village

AC Hotel Des Moines East Village
3.0 star property
Historic East Village, 1 km from Science Center of Iowa
9.0 out of 10, Wonderful, (451 reviews)
"Clean updated hotel , lobby was great bar was nice . Shuttle ride to airport which was convenient"
United States
Marcia
The price is AEDĀ 520
AEDĀ 582 total
includes taxes & fees
22 Nov - 23 Nov
AC Hotel Des Moines East Village
A spacious hotel lobby with a blue sofa, a grey armchair, and a flat-screen TV mounted on a textured wall.

10. Comfort Inn & Suites Event Center

Comfort Inn & Suites Event Center
2.5 star property
Downtown Des Moines, 1.2 km from Science Center of Iowa
8.8 out of 10, Excellent, (1,012 reviews)
"One of the nicest comfort inns Iā€™ve stayed at it was very quiet for being in a busy spot of town"
United States
Ana
The price is AEDĀ 340
AEDĀ 381 total
includes taxes & fees
25 Nov - 26 Nov
Comfort Inn & Suites Event Center
A spacious lobby with a bar area, seating arrangements, and a high ceiling with recessed lighting.

11. Des Moines Marriott Downtown

Des Moines Marriott Downtown
3.5 star property
Downtown Des Moines, 0.7 km from Science Center of Iowa
8.8 out of 10, Excellent, (1,005 reviews)
"Love the location of this hotel! Close to all things downtown and the shuddle is an added bonus!"
United States
Benjamin
The price is AEDĀ 496
AEDĀ 555 total
includes taxes & fees
16 Nov - 17 Nov
Des Moines Marriott Downtown
An outdoor seating area with a circular fire pit, wicker furniture, and string lights.

12. Residence Inn Des Moines Downtown

Residence Inn Des Moines Downtown
3.0 star property
Court District, 0.2 km from Science Center of Iowa
8.8 out of 10, Excellent, (695 reviews)
"Good location"
United States
Jill
The price is AEDĀ 385
AEDĀ 431 total
includes taxes & fees
29 Nov - 30 Nov
Residence Inn Des Moines Downtown
A modern dining area with a large island table, multiple chairs, and a chandelier.

13. Hampton Inn & Suites Des Moines Downtown

Hampton Inn & Suites Des Moines Downtown
2.5 star property
Court District, 0.2 km from Science Center of Iowa
8.6 out of 10, Excellent, (1,006 reviews)
"Friendly staff and decent breakfast."
United States
Kristy
The price is AEDĀ 389
AEDĀ 435 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites Des Moines Downtown
Living room

14. Renaissance Des Moines Savery Hotel

Renaissance Des Moines Savery Hotel
3.5 star property
Downtown Des Moines, 0.6 km from Science Center of Iowa
8.6 out of 10, Excellent, (1,000 reviews)
"Good location for downtown events. Clean room but Incredibly small bathroom. Attempted to grab a bite and drink at the Revelry Room but they were very understaffed."
United States
Amy
The price is AEDĀ 434
AEDĀ 486 total
includes taxes & fees
24 Nov - 25 Nov
Renaissance Des Moines Savery Hotel
An outdoor dining area with a table set for two, a city skyline in the background, and a Ferris wheel illuminated against the evening sky.

15. Embassy Suites by Hilton Des Moines Downtown

Embassy Suites by Hilton Des Moines Downtown
3.5 star property
Historic East Village, 0.7 km from Science Center of Iowa
8.4 out of 10, Very good, (1,000 reviews)
"First time at this hotel in Des Moines downtown. Entire experience was wonderful. The morning breakfast was the best we have ever had from a hotel stay. Within walking distance of everything we wanted to do downtown."
United States
Patty
The price is AEDĀ 479
AEDĀ 536 total
includes taxes & fees
16 Nov - 17 Nov
Embassy Suites by Hilton Des Moines Downtown
A multi-story hotel with a classic brick facade, large windows, and a prominent Liberty Building sign.

16. Hyatt Place Des Moines/Downtown

Hyatt Place Des Moines/Downtown
3.0 star property
Downtown Des Moines, 0.7 km from Science Center of Iowa
8.2 out of 10, Very good, (1,007 reviews)
"I stayed for 2 nights. It was quiet, clean, the staff was friendly and helpful, and the breakfast was very nice."
United States
Valerie
The price is AEDĀ 403
AEDĀ 451 total
includes taxes & fees
12 Nov - 13 Nov
Hyatt Place Des Moines/Downtown
A hotel room with a large bed, two bedside tables, a headboard, and a wall-mounted light fixture.

17. Cozy Rest Motel

Cozy Rest Motel
2.0 star property
Indianola Hills, 2.7 km from Science Center of Iowa
7.8 out of 10, Good, (694 reviews)
"Great location and helpful staff."
United States
Junette
The price is AEDĀ 256
AEDĀ 286 total
includes taxes & fees
9 Dec - 10 Dec
Cozy Rest Motel
A Holiday Inn hotel with a prominent green sign, a flagpole with an American flag, and a landscaped garden area.

18. Holiday Inn Downtown - Mercy Area by IHG

Holiday Inn Downtown - Mercy Area by IHG
3.0 star property
Downtown Des Moines, 1.6 km from Science Center of Iowa
7.6 out of 10, Good, (1,001 reviews)
"Rooms were clean. Enjoyed the bar on first floor and availability of morning breakfast Sunday."
United States
Mark
The price is AEDĀ 474
AEDĀ 531 total
includes taxes & fees
11 Nov - 12 Nov
Holiday Inn Downtown - Mercy Area by IHG
A building with a sign reading "WILDWOOD LODGE."

19. Wildwood Lodge

Wildwood Lodge
3.0 star property
13 km from Science Center of Iowa
9.6 out of 10, Exceptional, (1,236 reviews)
"Great place for family"
United States
Akacia
The price is AEDĀ 328
AEDĀ 368 total
includes taxes & fees
22 Nov - 23 Nov
Wildwood Lodge
An outdoor seating area with yellow chairs and a colorful sofa, a fire pit, and a wooden ceiling with hanging lights.

20. Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University
3.0 star property
Drake, 3.3 km from Science Center of Iowa
9.4 out of 10, Exceptional, (1,012 reviews)
"We enjoyed our stay. The staff are fantastic, the room was great, and the breakfast was delicious. We loved the large, spacious room, and the bed was very comfortable."
United States
Diane
The price is AEDĀ 340
AEDĀ 381 total
includes taxes & fees
25 Nov - 26 Nov
Home2 Suites by Hilton Des Moines at Drake University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Science Center of Iowa

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spacious lobby with high ceilings, large windows, and a chandelier.
Hotel Fort Des Moines, Curio Collection by Hilton
4.5 star property
9.6
Exceptional
1,422 reviews
View
A luxurious living room with a stone fireplace, a large mirror, and two blue armchairs.
Des Lux Hotel
3.5 star property
9.6
Exceptional
1,119 reviews
View
A modern bar with wooden shelves and a long counter.
Surety Hotel, Autograph Collection
4.0 star property
9.4
Exceptional
1,002 reviews
View
A modern building with a sign that reads 'Staybridge Suites.' It features a mix of glass and brick facades, large windows, and a flat roof.
Staybridge Suites Des Moines Downtown by IHG
3.0 star property
9.2
Wonderful
1,001 reviews
View
An indoor swimming pool with clear water, a no diving sign, and a pool ladder.
Holiday Inn Express & Suites Des Moines Downtown by IHG
2.5 star property
9.2
Wonderful
1,006 reviews
View

Other attractions near Science Center of Iowa

Principal Park

8.6/10 (133 reviews)
Catch an event at Principal Park during your trip to Des Moines. Experience the area's lively festivals and great live music.
See properties

Top Science Center of Iowa Hotel Reviews

A spacious lobby with high ceilings, large windows, and a chandelier.
Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton
Downtown Des Moines

10/10 Excellent

This is one of the nicest hotels Iā€™ve ever stayed at. Absolutely beautiful historic building with a grand scale and fully updated modern rooms. The design and comfort is impeccable. Large room and bathroom, but not so large that it isnā€™t cozy. Perfect in my opinion. The onsite dining options are fantastic for world class breakfast lunch and dinner at very reasonable prices. And the coffee is amazing. There were a couple of quirks in the roomā€”the sound of trickling water whenever the ac turned...
United States
David Morrow
Reviewed July 28, 2025
Hotel Fort Des Moines, Curio Collection by Hilton

Frequently Asked Questions

What's the area like around Science Center of Iowa?

Science Center of Iowa is located in an area of Des Moines known for its lively festivals. If you're looking for a convenient place to stay, check out the 141 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay close to Science Center of Iowa?

Adjacent to Science Center of Iowa, Hampton Inn & Suites Des Moines Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Other good options close by include Hotel Fort Des Moines, Curio Collection by Hilton and Des Lux Hotel.

How many hotels will I be able to find near Science Center of Iowa?

Expedia has 141 hotels and other accommodations within a mile from Science Center of Iowa.

If I need to cancel the hotel reservation for my stay near Science Center of Iowa, will I receive a refund?

Yes! The majority of hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to get the best deals available near Science Center of Iowa.

Where can I learn more about changing or cancelling my trip in the area near Science Center of Iowa?

To access more information about rescheduling or cancelling your stay near Science Center of Iowa, click here.

What can I see and do near Science Center of Iowa?

World Food Prize Hall of Laureates, Des Moines Art Center, and Pappajohn Sculpture Park feature a variety of fascinating exhibits to see while you're in town. Salisbury House, Valley Junction, and Walnut Street Bridge are some of the notable landmarks to see in the area. You can check out the local talent at Wooly's, Hoyt Sherman Place, and Lauridsen Amphitheater.