Serra Mesa Vacations

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Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Serra Mesa Hotel Deals

Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 625 per night from May 27 to May 28
AED 625
AED 899 total
includes taxes & fees
27 May - 28 May
9/10 Wonderful! (2,760 reviews)
"Everything was wonderful. Just enjoy a good weekend."

Reviewed on 16 May 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 657 per night from May 21 to May 22
AED 657
AED 756 total
includes taxes & fees
21 May - 22 May
8.8/10 Excellent! (3,405 reviews)
"It’s was okay just don’t like the carpet"

Reviewed on 17 May 2025

The Dana on Mission Bay
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AED 841 per night from May 26 to May 27
AED 841
AED 1,132 total
includes taxes & fees
26 May - 27 May
8.2/10 Very Good! (1,236 reviews)
"We got upgraded to literally the best room possible. Floor level, fire pit, steps away from the shoreline. So happy and so grateful. Such a beautiful room inside and out."

Reviewed on 20 May 2025

San Diego Mission Bay Resort
See all 8,676 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Serra Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

Why not visit the animals who live at San Diego Zoo and see why this is a favorite attraction in San Diego? Stroll along the area's beautiful beaches or experience its fascinating museums.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the beautiful beaches in this family-friendly area, or check out its top-notch restaurants.

Mission Bay