Find hotels in South Main, Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,374 reviews)
"Room was clean and the staff was very nice."
Juan
The price is AED 337
AED 395 total
includes taxes & fees
2 Aug - 3 Aug
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,006 reviews)
"Friendly staff. Nice comfortable room at a very reasonable rate. Lobby area was very clean. The pool area however left much to be desired; it was small and not clean at all."
ken
The price is AED 365
AED 427 total
includes taxes & fees
29 Aug - 30 Aug
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Good parking"
joseph
The price is AED 309
AED 362 total
includes taxes & fees
2 Aug - 3 Aug
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"convenient to medical center"
Mike
The price is AED 217
AED 254 total
includes taxes & fees
29 Aug - 30 Aug
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (889 reviews)
"This place had"
Marvin
The price is AED 223
AED 261 total
includes taxes & fees
29 Aug - 30 Aug
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd32 km from South Main
9.2 out of 10, Wonderful, (1,008 reviews)
"Great location and excellent staff"
Brian William
The price is AED 282
AED 324 total
includes taxes & fees
9 Aug - 10 Aug
Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear LakeNassau Bay, 31.8 km from South Main
8.0 out of 10, Very Good, (1,019 reviews)
"I love this hotel!!"
Iliana
The price is AED 220
AED 258 total
includes taxes & fees
30 Jul - 31 Jul
Studio 6 Deer Park, TX
Studio 6 Deer Park, TX28.7 km from South Main
9.4 out of 10, Exceptional, (444 reviews)
"Management is great, clean rooms. A home away from home"
Martavian
The price is AED 292
AED 342 total
includes taxes & fees
31 Jul - 1 Aug
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (769 reviews)
"The staff was really attentive, rooms were clean and it was a good price for our stay"
MARIA
The price is AED 182
AED 210 total
includes taxes & fees
30 Jul - 31 Jul
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"It’s a very neat hotel very closer to Costco the rooms and the lobby and the lift everything is clean. I would highly recommend people to stay here."
Tarun Kumar
The price is AED 285
AED 333 total
includes taxes & fees
23 Aug - 24 Aug
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place, clean and modern."
Wei
The price is AED 328
AED 384 total
includes taxes & fees
9 Aug - 10 Aug
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (52 reviews)
"Great space"
Domingos
The price is AED 277
AED 324 total
includes taxes & fees
30 Jul - 31 Jul
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (188 reviews)
"Best choice I made was going here wish I had picked just this one to stay at while in houston"
William
The price is AED 371
AED 448 total
includes taxes & fees
30 Jul - 31 Jul
Houston Marriott South at Hobby Airport
Houston Marriott South at Hobby AirportSoutheast Houston, 15.7 km from South Main
8.8 out of 10, Excellent, (1,520 reviews)
"good breakfast clean room very friendly staff "
Abdellah
The price is AED 426
AED 512 total
includes taxes & fees
14 Aug - 15 Aug
Best Western Plus Hobby Airport Inn & Suites
Best Western Plus Hobby Airport Inn & Suites15.3 km from South Main
8.8 out of 10, Excellent, (1,620 reviews)
"Room clean, staff very polite."
Mari
The price is AED 281
AED 329 total
includes taxes & fees
5 Aug - 6 Aug
La Quinta Inn & Suites by Wyndham Houston Channelview
La Quinta Inn & Suites by Wyndham Houston ChannelviewNortheast Houston, 28.6 km from South Main
8.6 out of 10, Excellent, (969 reviews)
"Great stay staff friendly in general everything was great"
christopher
The price is AED 311
AED 364 total
includes taxes & fees
16 Aug - 17 Aug
Hilton Garden Inn Houston Hobby Airport, TX
Hilton Garden Inn Houston Hobby Airport, TX15 km from South Main
8.8 out of 10, Excellent, (1,001 reviews)
"Super close to Enterprise drop-point and Houston Hobby airport."
Dora
The price is AED 358
AED 419 total
includes taxes & fees
14 Aug - 15 Aug
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,033 reviews)
"Convenient to airport"
Daniel
The price is AED 328
AED 388 total
includes taxes & fees
15 Aug - 16 Aug
Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very Good, (1,252 reviews)
"Room was clean and early check in was very helpful and inexpensive"
Mary Eloise
The price is AED 238
AED 278 total
includes taxes & fees
11 Aug - 12 Aug
Holiday Inn Express & Suites Houston - Hobby Airport Area by IHG
Holiday Inn Express & Suites Houston - Hobby Airport Area by IHG16 km from South Main
8.4 out of 10, Very Good, (1,000 reviews)
"Friendly staff"
Martin
The price is AED 285
AED 333 total
includes taxes & fees
2 Aug - 3 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,006 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,374 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 889 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,002 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
Hilton Houston Plaza/Medical Center
10/10 Excellent
