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South Main Vacations

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

South Main Hotel Deals

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,010 reviews)
"I checked in late at night. Unfortunately, the bathroom sink stopper was stuck closed, making the sink unusable. Staff said no other rooms were available and no one was available to fix it, leaving me to use the bathtub instead. Very frustrating and disappointing experience. I expected better room maintenance and customer service."
The price is AED 326
AED 381 total
includes taxes & fees
2 Dec - 3 Dec
Comfort Suites Houston near Medical Center- NRG Stadium
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.