The Best Business Hotels in Southeast Iowa from AED 288 in 2026 | Expedia

A paved courtyard with a brick pathway, trees, and a distant view of a road and buildings.

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Check availability on Southeast Iowa Business Hotels

Tonight

18 Oct - 19 Oct

Tomorrow

19 Oct - 20 Oct

Next weekend

23 Oct - 25 Oct

In two weeks

Our top choices for Southeast Iowa business-friendly hotels

A lobby with a stone fireplace, comfortable seating, and a flat-screen TV mounted on the wall.

A spacious lobby with a leather sofa, dining area, and a TV mounted on a stone wall.

A hotel room with two beds, a television, a desk with a lamp, and a chair.

A fire pit surrounded by outdoor furniture, including a sofa and chairs, in a patio area.

1. Cobblestone Inn & Suites - Fort Madison

Fort Madison

United States

Hunter

AED 349

AED 391 total

includes taxes & fees

22 Oct - 23 Oct

A spacious living area with a wooden staircase, a stone fireplace, and a reception desk.

A hotel room with two beds, a large window, a standing lamp, and a patterned carpet.

A reception area with a stone wall, wooden reception desk, and a sign that reads "Quality".

An indoor swimming pool with clear water, surrounded by a white fence, and equipped with multiple entry points and seating areas.

2. Quality Inn & Suites Fort Madison near Hwy 61

Fort Madison

United States

Sharon

AED 300

AED 336 total

includes taxes & fees

15 Nov - 16 Nov

A spacious living room with a large sofa, two armchairs, a coffee table, and a fireplace.

A hotel room with a bed, a TV, a desk, and a chair.

A modern kitchen with a granite countertop, wooden chairs, and a large painting of a colorful horse.

A cozy living room with a grey sofa, two patterned armchairs, a wooden coffee table, and a brick accent wall.

3. AmericInn by Wyndham Mount Pleasant

Mount Pleasant

United States

brian

AED 278

AED 311 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a wooden ceiling, grey tiled floor, and several lounge chairs and tables around the pool area.

A spa area with a hot tub, wooden ceiling, and tiled walls.

A modern hotel lobby with blue and pink seating, a central coffee table, and a kitchen area in the background.

A multi-story hotel with a central entrance, a parking lot, and a clear sky.

4. Quality Inn & Suites Keokuk North

Keokuk

United States

Bradley

AED 337

AED 377 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a bed, a sofa, a small table, a chair, a nightstand, and a painting on the wall.

A modern kitchen with a dining area, featuring a central island, built-in appliances, and a large window with blinds.

A living room with a sofa, two armchairs, a coffee table with a plant, a lamp, and a TV on the wall.

A modern reception area with a dark granite counter, light-colored walls, and a seating area with a sofa and chairs.

5. Best Western Mt. Pleasant Inn

Mount Pleasant

United States

Paul

AED 286

AED 321 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a chair, and a large window.

A Super 8 motel with a brick facade, a covered entrance, and a parking lot with cars.

A reception area with a white sofa, a potted plant, and a framed picture on the wall.

A small, clean room with a kitchenette, a coffee machine, a microwave, and a TV mounted on the wall. There are two tables and chairs, and a window providing natural light.

6. Super 8 by Wyndham Mt Pleasant

Mount Pleasant

United States

JOSE

AED 257

AED 288 total

includes taxes & fees

8 Nov - 9 Nov

A neatly made bed with patterned bedding and pillows, a wooden headboard, bedside lamps, and framed pictures on the wall.

A compact kitchen with wooden cabinets, a microwave, a coffee maker, and a dishwasher.

A bedroom with a large bed, a bedside table with a lamp, a window with blinds, and a framed picture on the wall.

A living room with a sofa, a patterned armchair, a dining table with chairs, a kitchen area with wooden cabinets and a refrigerator, and a television on a stand.

7. Nauvoo Vacation Villas & Condos

Nauvoo

United States

Renae

AED 508

AED 538 total

includes taxes & fees

26 Oct - 27 Oct

A Holiday Inn Express hotel with a covered entrance, multiple windows, and a well-lit facade.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A hotel room with a bed, a desk, a chair, a window, and a bathtub.

A modern bathroom with a white sink, a mirror, and a coffee maker on a shelf.

8. Holiday Inn Express Hotel & Suites Burlington by IHG

Burlington

United States

Samantha

AED 492

AED 567 total

includes taxes & fees

15 Nov - 16 Nov

View all properties

Top Southeast Iowa Hotel Reviews

Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant

8/10 Good

"The room was spotless"

Super 8 by Wyndham Burlington

Super 8 by Wyndham Burlington

8/10 Good

"Nice place to stay off the highway Coffee is good and the people are nice Next to restaurants and the gym 😊"

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk

8/10 Good

"I didn’t have any issues with the staff, the cleanliness, or the amenities, however, I did find what looked like a mouse that chewed into one of the breakfast items."