The Best Business Hotels in Southeast Iowa from AED 288 in 2026 | Expedia

A paved courtyard with a brick pathway, trees, and a distant view of a road and buildings.

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Check availability on Southeast Iowa Business Hotels

Tonight

17 Oct - 18 Oct

Tomorrow

18 Oct - 19 Oct

Next weekend

23 Oct - 25 Oct

In two weeks

Our top choices for Southeast Iowa business-friendly hotels

A lobby with a stone fireplace, comfortable seating, and a flat-screen TV mounted on the wall.

A reception area with a reception desk, a plant, and a sign for Boulders Inn & Suites.

A hotel room with two beds, a television, a desk with a lamp, and a chair.

A spacious lobby with a leather sofa, dining area, and a TV mounted on a stone wall.

1. Cobblestone Inn & Suites - Fort Madison

Fort Madison

United States

Hunter

AED 349

AED 391 total

includes taxes & fees

18 Oct - 19 Oct

A spacious living area with a wooden staircase, a stone fireplace, and a reception desk.

An indoor swimming pool with clear water, surrounded by a white fence, and equipped with multiple entry points and seating areas.

A hotel room with a bed, a desk, a sofa, a lamp, and a mirror.

A hotel room with two beds, a large window, a standing lamp, and a patterned carpet.

2. Quality Inn & Suites Fort Madison near Hwy 61

Fort Madison

United States

Sharon

AED 300

AED 336 total

includes taxes & fees

15 Nov - 16 Nov

A spacious living room with a large sofa, two armchairs, a coffee table, and a fireplace.

An indoor swimming pool with wooden walls and a balcony.

A hotel room with a bed, a TV, a desk, and a chair.

A modern kitchen with a granite countertop, wooden chairs, and a large painting of a colorful horse.

3. AmericInn by Wyndham Mount Pleasant

Mount Pleasant

United States

brian

AED 278

AED 311 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a wooden ceiling, grey tiled floor, and several lounge chairs and tables around the pool area.

A multi-story hotel with a central entrance, a parking lot, and a clear sky.

A modern hotel lobby with blue and pink seating, a central coffee table, and a kitchen area in the background.

A hotel room with a large bed, a desk with a computer, a chair, a window with curtains, and a view of the city.

4. Quality Inn & Suites Keokuk North

Keokuk

United States

Bradley

AED 337

AED 377 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a bed, a sofa, a small table, a chair, a nightstand, and a painting on the wall.

A home gym with a treadmill, elliptical, and stationary bike, a large mirror, and a framed picture on the wall.

A modern reception area with a dark granite counter, light-colored walls, and a seating area with a sofa and chairs.

A living room with a sofa, two armchairs, a coffee table with a plant, a lamp, and a TV on the wall.

5. Best Western Mt. Pleasant Inn

Mount Pleasant

United States

Paul

AED 286

AED 321 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a chair, and a large window.

A bathroom with a bathtub, toilet, and sink.

A Super 8 motel with a brick facade, a covered entrance, and a parking lot with cars.

A small, clean room with a kitchenette, a coffee machine, a microwave, and a TV mounted on the wall. There are two tables and chairs, and a window providing natural light.

6. Super 8 by Wyndham Mt Pleasant

Mount Pleasant

United States

JOSE

AED 257

AED 288 total

includes taxes & fees

8 Nov - 9 Nov

A large indoor swimming pool with a lifeguard chair, poolside chairs, and a view of the outside through large windows.

A breakfast buffet area with a sign reading "EAT HERE" and various food items like cereal and pastries.

A modern hotel room with a large bed, two bedside tables with lamps, a small sofa, and a desk.

A reception desk with a "Welcome to the Hawk Eye State" sign, a digital kiosk, and a "Manager On Duty" sign.

7. Hampton Inn Keokuk

Keokuk

United States

Kristopher

AED 372

AED 416 total

includes taxes & fees

1 Nov - 2 Nov

A patio area with Adirondack chairs and a central fire pit.

A spacious dining area with multiple tables and chairs, a television on a shelf, and a large chandelier.

A modern hotel with a brick facade, large windows, and a covered entrance.

A hotel room with a bed, a desk, a chair, and a TV.

8. Hampton Inn & Suites Burlington

Burlington

United States

Susan

AED 450

AED 536 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Top Southeast Iowa Hotel Reviews

Cobblestone Inn & Suites - Fort Madison

Cobblestone Inn & Suites - Fort Madison

10/10 Excellent

"The inn was wonderful in every way. The only problem I did not forsee is that the bridge crossing the Mississippi river was out of commission for two months. That made us take a very long trip down to Keokuk to cross the river with the very high price of gasoline."

Super 8 by Wyndham Burlington

Super 8 by Wyndham Burlington

8/10 Good

"Nice place to stay off the highway Coffee is good and the people are nice Next to restaurants and the gym 😊"

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk

8/10 Good

"I didn’t have any issues with the staff, the cleanliness, or the amenities, however, I did find what looked like a mouse that chewed into one of the breakfast items."