The Best Resorts & Hotels with Spas in Southeast Iowa from AED 269 in 2026 | Expedia

A paved courtyard with a brick pathway, trees, and a distant view of a road and buildings.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Southeast Iowa Resorts & Hotels with Spas

Tonight

Tomorrow

10 Oct - 11 Oct

This weekend

Next weekend

16 Oct - 18 Oct

No exact matches found, but these alternatives could be just right

Recommended hotels in Southeast Iowa

A lobby with a stone fireplace, comfortable seating, and a flat-screen TV mounted on the wall.

A hotel room with two beds, a television, a desk with a lamp, and a chair.

A spacious lobby with a leather sofa, dining area, and a TV mounted on a stone wall.

A fire pit surrounded by outdoor furniture, including a sofa and chairs, in a patio area.

1. Cobblestone Inn & Suites - Fort Madison

Fort Madison

AED 349

AED 391 total

includes taxes & fees

14 Oct - 15 Oct

A spacious living area with a wooden staircase, a stone fireplace, and a reception desk.

A reception area with a stone wall, wooden reception desk, and a sign that reads "Quality".

A hotel room with a bed, a desk, a sofa, a lamp, and a mirror.

An indoor swimming pool with clear water, surrounded by a white fence, and equipped with multiple entry points and seating areas.

2. Quality Inn & Suites Fort Madison near Hwy 61

Fort Madison

AED 308

AED 345 total

includes taxes & fees

1 Nov - 2 Nov

A spacious living room with a large sofa, two armchairs, a coffee table, and a fireplace.

A modern kitchen with a granite countertop, wooden chairs, and a large painting of a colorful horse.

A hotel room with a bed, a TV, a desk, and a chair.

An indoor swimming pool with wooden walls and a balcony.

3. AmericInn by Wyndham Mount Pleasant

Mount Pleasant

AED 278

AED 311 total

includes taxes & fees

8 Nov - 9 Nov

A guest registration area with a counter, informational signs, and various items on shelves.

A hotel room with a bed, bedside lamps, a nightstand, a refrigerator, and a wooden headboard.

An indoor swimming pool with a wooden ceiling and walls, a bench, and a rack of towels.

A bathroom with a toilet, a shower, and a bathtub.

4. The Inn at Old Nauvoo

Nauvoo

AED 449

AED 508 total

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a wooden ceiling, grey tiled floor, and several lounge chairs and tables around the pool area.

A multi-story hotel with a central entrance, a parking lot, and a clear sky.

A spa area with a hot tub, wooden ceiling, and tiled walls.

A modern hotel lobby with blue and pink seating, a central coffee table, and a kitchen area in the background.

5. Quality Inn & Suites Keokuk North

Keokuk

AED 338

AED 379 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a sofa, a small table, a chair, a nightstand, and a painting on the wall.

A modern reception area with a dark granite counter, light-colored walls, and a seating area with a sofa and chairs.

A living room with a sofa, two armchairs, a coffee table with a plant, a lamp, and a TV on the wall.

A bathroom with a granite countertop sink, a mirror, a toilet, a shower with a beige curtain, and a marble wall.

6. Best Western Mt. Pleasant Inn

Mount Pleasant

AED 286

AED 321 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk, a chair, and a large window.

A bathroom with a bathtub, toilet, and sink.

A small, clean room with a kitchenette, a coffee machine, a microwave, and a TV mounted on the wall. There are two tables and chairs, and a window providing natural light.

A Super 8 motel with a brick facade, a covered entrance, and a parking lot with cars.

7. Super 8 by Wyndham Mt Pleasant

Mount Pleasant

AED 257

AED 288 total

includes taxes & fees

8 Nov - 9 Nov

A room with a large window, a sofa, and a chair.

A staircase with red carpeted steps leading to a landing with white doors and a red EXIT sign.

A living room with a flat-screen TV on a white console, a grey sofa, and a framed picture on the wall.

A brick building with a balcony, a staircase, and a sign reading "Zions Mercantile".

8. Nauvoo Temple House Hotel

Nauvoo

AED 363

AED 426 total

includes taxes & fees

31 Oct - 1 Nov

View all properties

Choose what matters most at spa hotels in Southeast Iowa

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Southeast Iowa Hotel Reviews

Quality Inn & Suites Keokuk North

Quality Inn & Suites Keokuk North

8/10 Good

"The Staff, both check in and then Mary during breakfast was so awesome! You will be well treated there!"

Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant

10/10 Excellent

"Good stay for the price. Clean and comfortable room."