Southeast Missouri Vacations
Book a Hotel + Flight together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to AEDĀ 5,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Find the Best Southeast Missouri Vacation Packages
Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AEDĀ 367 per night from Nov 15 to Nov 16
AEDĀ 367
AEDĀ 414 total
15 Nov - 16 Nov
includes taxes & fees
Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
The price is AEDĀ 328 per night from Nov 29 to Nov 30
AEDĀ 328
AEDĀ 367 total
29 Nov - 30 Nov
includes taxes & fees
9.4/10 Exceptional! (1,020 reviews)
"Everything was great, especially the room which was nicely decorated and the bath was very nice. The only thing that makes me reluctant to come again is that I saw someone going out with their dog. Makes me wonder if I am sleeping in a bed where a dog has slept or walking on carpet where a pet has ..."
Reviewed on 11 November 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is AEDĀ 200 per night from Nov 18 to Nov 19
AEDĀ 200
AEDĀ 228 total
18 Nov - 19 Nov
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
