Find Resorts & Hotels with Spas in Southern Illinois, IL
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southern Illinois Resorts & Hotels with Spas
Tonight
18 Sep - 19 SepTomorrow
19 Sep - 20 SepThis weekend
18 Sep - 20 SepNext weekend
25 Sep - 27 SepOur top choices for Southern Illinois hotels with a spa
1. Walker's Bluff Casino Resort
Walker's Bluff Casino ResortCarterville
- Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
AED 622
AED 690 total
includes taxes & fees
21 Sep - 22 Sep
2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
- Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
AED 371
AED 422 total
includes taxes & fees
27 Sep - 28 Sep
3. 1895 Washington Hotel
1895 Washington HotelPaducah
- Unwind in a Victorian sanctuary with relaxing reflexology and soothing hydrotherapy treatments for total rejuvenation.
AED 181
AED 245 total
includes taxes & fees
24 Sep - 25 Sep
4. Ameristar Casino Resort and Spa
Ameristar Casino Resort and SpaSt. Charles
- Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
AED 548
AED 702 total
includes taxes & fees
12 Oct - 13 Oct
AED 617
AED 749 total
includes taxes & fees
20 Sep - 21 Sep
AED 441
AED 489 total
includes taxes & fees
20 Sep - 21 Sep
7. 21C Museum Hotel St Louis
21C Museum Hotel St LouisDowntown West
- Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
AED 528
AED 635 total
includes taxes & fees
11 Oct - 12 Oct
8. Four Seasons Hotel St Louis
Four Seasons Hotel St LouisDowntown St. Louis
- Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
AED 1,377
AED 1,611 total
includes taxes & fees
21 Sep - 22 Sep
View all properties
Top Southern Illinois Hotel Reviews
Quality Inn O'Fallon - St. Louis - Shiloh
10/10 Excellent
"I stay here often when in the Metro area. The hotel is older but clean and affordable. Great location from St Louis and plenty of shopping and dining close by. Staff is always nice and gives good service. My room was clean and comfortable. I recommend this for an easy stay in the area."
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
"Well maintained facility; friendly, helpful staff; breakfast and the 'Kick-Back' offered excellent variety and was very tasty. Stayed there before and plan to stay again!"
Country Inn & Suites by Radisson, Effingham, IL
10/10 Excellent
"This place was very clean. The bed was super comfortable and the sheets were silky soft."
Drury Inn & Suites St. Louis Fairview Heights
10/10 Excellent
"Clean rooms awesome breakfast and staff"
Comfort Suites Mount Vernon
10/10 Excellent
"Very nice new/updated hotel. Good breakfast. Sausage gravy both days we were there. It’s a good location with several restaurants walkable. The BBQ place across the street was great. My only complaint is the room air conditioning was very loud and had a rattling sound. It kept my wife and me up during the night."
Explore a world of travel with Expedia
- Hotels near Dix Village Hall
- Hilton Hotels in Opdyke
- Cabin Rentals in Hoyleton
- 5 Star Hotels in Salem
- Farmstay in Southern Illinois
- Best Western Hotels in Mulkeytown
- 2 Star Hotels in Belle Rive
- Family Hotels in Okawville
- Pet-Friendly Hotels in West Frankfort
- Aimbridge Hospitality Hotels in Sesser
- Hotels with a Pool in Carlyle
- 3 Star Hotels in Keenes
- America's Best Inns Hotels in Ewing
- America's Best Inns Hotels in Dix
- Wyndham Hotels in Centralia
- Resorts in Mulkeytown
- 5 Star Hotels in Benton
- Cottages in Whittington
- Hotels with Free Parking in Marion
- Hotels near Pheasant Hollow Winery
- Aimbridge Hospitality Hotels in Centralia
- Best Western Hotels in Mount Vernon
- Wyndham Hotels in Keenes
- Independent Hotels in Sims
- 3 Star Hotels in McLeansboro
- Wyndham Hotels in Sesser
- Cabin Rentals in Ewing
- 5 Star Hotels in Bluford
- Wyndham Hotels in Benton
- Resorts & Hotels with Spas in Mount Vernon
- Historic Hotels in Carbondale
- Red Roof Inn Hotels in Centralia
- Benton Hotels
- Wyndham Hotels in Odin
- Condo Rentals in Benton
- 4 Star Hotels in Keenes
- Pet-Friendly Hotels in Carlyle
- Romantic Hotels in Marion
- Motels in Centralia
- 4 Star Hotels in Mount Vernon
- Wyndham Hotels in Opdyke
- Aimbridge Hospitality Hotels in Belle Rive
- Motel 6 Hotels in Opdyke
- Rv Parks in Christopher
- Aimbridge Hospitality Hotels in Ewing
- Marriott Hotels & Resorts in Centralia
- Cabin Rentals in Southern Illinois
- 3 Star Hotels in Hoyleton
- Motel 6 Hotels in Centralia
- Motel 6 Hotels in Odin
- Motels in Tamaroa
- Hotels with WiFi in Mount Vernon
- Red Roof Inn Hotels in Opdyke
- Romantic Hotels in Southern Illinois
- Hotels with Hot Tubs in Salem
- Golf Hotels in Flora
- Cabin Rentals in Mulkeytown
- Pet-Friendly Hotels in Carterville
- Opdyke Hotels
- Pet-Friendly Hotels in Whittington
- Marriott Hotels & Resorts in Christopher
- Apartments in Benton
- Lodges in Salem
- 3 Star Hotels in Sesser
- Independent Hotels in Salem
- Waltonville Hotels
- Family Hotels in Southern Illinois
- 3 Star Hotels in Opdyke
- 3 Star Hotels in Sims
- Hotels with Free Parking in Okawville
- Hotels with WiFi in Flora
- 2 Star Hotels in Keenes
- 4 Star Hotels in McLeansboro
- Pet-Friendly Hotels in Mount Vernon
- 5 Star Hotels in McLeansboro
- 4 Star Hotels in Sims
- Independent Hotels in Ewing
- Adventure Hotels in Mount Vernon
- Cabin Rentals in Salem
- Hotels with Free Parking in Albion
- Resorts & Hotels with Spas in Carbondale
- Marriott Hotels & Resorts in Ina
- Aimbridge Hospitality Hotels in Benton
- Motels in Odin
- 5 Star Hotels in Odin
- Hotels near I-57 Drag Strip
- Hilton Hotels in Centralia
- Flights from Hoyleton
- Flights from Benton
- Flights from Dix
- Flights from Mulkeytown
- Flights from Ewing
- Flights from Waltonville
- Flights from McLeansboro
- Flights from Southern Illinois
- Flights from Mount Vernon Outland
- Flights from Whittington
- Flights from Mount Vernon
- Flights to Mount Vernon
- Flights from Christopher