A forested valley with autumn foliage, a rocky cliff, and a sunset.

Search Vacation Homes in Southern Illinois

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Southern Illinois vacation homes

1. Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64

Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64
Ina
9.8 out of 10, Exceptional, (29 reviews)
"Very clean, host was very helpful, comfortable beds, fishing was great! Would stay again!"
United States
Contina S.
The price is AED 386
AED 779 total
includes taxes & fees
19 Nov - 20 Nov
Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64

2. Pigs Ina Blanket - Minutes from Rend Lake and I-64/I-57

Pigs Ina Blanket - Minutes from Rend Lake and I-64/I-57
Ina
8.8 out of 10, Excellent, (38 reviews)
"Great place. Clean and comfortable!"
United States
Bill M.
The price is AED 393
AED 1,086 total
includes taxes & fees
11 Nov - 12 Nov
Pigs Ina Blanket - Minutes from Rend Lake and I-64/I-57

3. Vintage Charmer on Main Street

Vintage Charmer on Main Street
Greenup
10.0 out of 10, Exceptional, (79 reviews)
"Great stay !"
United States
chris H.
The price is AED 324
AED 487 total
includes taxes & fees
3 Nov - 4 Nov
Vintage Charmer on Main Street

4. Terrific 1-bedroom Loft with Balcony in Mount Vernon. 1.2 mile Hiking trail.

Terrific 1-bedroom Loft with Balcony in Mount Vernon. 1.2 mile Hiking trail.
Mount Vernon
10.0 out of 10, Exceptional, (4 reviews)
"Cute little place to stay for a nice weekend away."
United States
Kendra K.
The price is AED 354
AED 519 total
includes taxes & fees
4 Nov - 5 Nov
Terrific 1-bedroom Loft with Balcony in Mount Vernon. 1.2 mile Hiking trail.

5. Brickway Retreat

Brickway Retreat
Mattoon
9.8 out of 10, Exceptional, (53 reviews)
"Great place for a stay. Nice amenities and very clean. Would absolutely stay again"
United States
Kevin F.
The price is AED 404
AED 607 total
includes taxes & fees
4 Nov - 5 Nov
Brickway Retreat

6. The Clark: Where Superheroes Sleep!

The Clark: Where Superheroes Sleep!
Metropolis
9.8 out of 10, Exceptional, (18 reviews)
"This property is amazing and the attention to detail is fantastic. We had a super stay and hope to come back soon!"
United States
Mallory H.
The price is AED 367
AED 533 total
includes taxes & fees
3 Nov - 4 Nov
The Clark: Where Superheroes Sleep!

7. Fish, boat, grill, chill, pets, relax

Fish, boat, grill, chill, pets, relax
Sullivan
9.4 out of 10, Exceptional, (72 reviews)
"The house was clean. Beds and couches were very comfortable. Great for our dogs."
United States
Vince S.
The price is AED 441
AED 860 total
includes taxes & fees
1 Dec - 2 Dec
Fish, boat, grill, chill, pets, relax

8. Soothing bungalow in charming Joppa

Soothing bungalow in charming Joppa
Joppa
The price is AED 360
AED 747 total
includes taxes & fees
4 Nov - 5 Nov
Soothing bungalow in charming Joppa

9. The Vault / Historical 1800s Bank 7min Off I-64. Downtown Main street

The Vault / Historical 1800s Bank 7min Off I-64. Downtown Main street
Fairfield
10.0 out of 10, Exceptional, (19 reviews)
"Just in town for a celebration. Very comfortable, clean and fun place to stay. "
United States
John D.
The Vault / Historical 1800s Bank 7min Off I-64. Downtown Main street

10. The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping

The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping
Harrisburg
10.0 out of 10, Exceptional, (33 reviews)
"It was convenient having a garage for our car and luckily our car is small, because it barely fit. Nonetheless, a great feature. The place was clean, quaint, and adequate for the two of us. It was decorated to feel very homey. I recommend this as an option to stay if you are in the Harrisburg, Shawnee National Forest area."
United States
Shirley
The price is AED 331
AED 564 total
includes taxes & fees
9 Nov - 10 Nov
The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping

11. Soothing 1-bedroom house in lovely Madison perfect for relaxing stays

Soothing 1-bedroom house in lovely Madison perfect for relaxing stays
Madison
The price is AED 294
AED 358 total
includes taxes & fees
7 Nov - 8 Nov
Soothing 1-bedroom house in lovely Madison perfect for relaxing stays

12. Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Kevil
9.8 out of 10, Exceptional, (83 reviews)
"Very nice and quiet place to stay while we went to the AQS quilt show in Paducah. "
United States
Curt K.
The price is AED 430
AED 537 total
includes taxes & fees
3 Nov - 4 Nov
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

13. Secluded treehouse with indoor fireplace

Secluded treehouse with indoor fireplace
Makanda
10.0 out of 10, Exceptional, (31 reviews)
"Very nice place. We enjoyed it."
United States
Gregory M.
The price is AED 441
AED 681 total
includes taxes & fees
5 Nov - 6 Nov
Secluded treehouse with indoor fireplace

14. In the Country a Beautiful 2-bedroom house with its own private lake

In the Country a Beautiful 2-bedroom house with its own private lake
Waterloo
10.0 out of 10, Exceptional, (42 reviews)
"Wonderful place!"
United States
Tina S.
The price is AED 579
AED 878 total
includes taxes & fees
15 Nov - 16 Nov
In the Country a Beautiful 2-bedroom house with its own private lake

15. Cozy country setting minutes from Rend Lake

Cozy country setting minutes from Rend Lake
Benton
10.0 out of 10, Exceptional, (53 reviews)
"Great place to stay very clean and comfortable "
United States
Thomas M.
Cozy country setting minutes from Rend Lake

16. Charming 1-bedroom house in terrific Harrisburg with AC, WiFi

Charming 1-bedroom house in terrific Harrisburg with AC, WiFi
Harrisburg
10.0 out of 10, Exceptional, (21 reviews)
"We stay here often perfect size and location. "
United States
Cher C.
The price is AED 426
AED 697 total
includes taxes & fees
1 Dec - 2 Dec
Charming 1-bedroom house in terrific Harrisburg with AC, WiFi

17. Charming 3 bedroom retreat

Charming 3 bedroom retreat
Herrin
10.0 out of 10, Exceptional, (4 reviews)
"Great property, very clean and had everything you could possibly need. We were in town for a wedding and this worked perfect for my group!!! Would definitely recommend!"
United States
Christina H.
Charming 3 bedroom retreat

18. Peter Ray House

Peter Ray House
Maeystown
10.0 out of 10, Exceptional, (77 reviews)
"This house was incredible. Loved the history and ambience of the town. Peter was one of the nicest homes I’ve stayed in over the years. I would highly recommend it."
United States
Eric
The price is AED 496
AED 782 total
includes taxes & fees
3 Nov - 4 Nov
Peter Ray House

19. Kindlewood ♡ Romantic 2BD Cozy Retreat & Tub with Fireplace, and Outdoor Living

Kindlewood ♡ Romantic 2BD Cozy Retreat & Tub with Fireplace, and Outdoor Living
Bluford
10.0 out of 10, Exceptional, (7 reviews)
"The property was absolutely gorgeous, very clean, exactly as beautiful as the pictures in a quiet nice neighborhood. The host was incredible as well! Highly recommend!"
United States
Brianna W.
The price is AED 606
AED 1,172 total
includes taxes & fees
15 Nov - 16 Nov
Kindlewood ♡ Romantic 2BD Cozy Retreat & Tub with Fireplace, and Outdoor Living

20. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (15 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
United States
Dylan
The price is AED 505
AED 1,007 total
includes taxes & fees
10 Nov - 11 Nov
Stunning 2 bedroom in town, close to Shawnee National Forest
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Southern Illinois Hotel Reviews

Explore a world of travel with Expedia