Photo by Southernmost Illinois Tourism Bureau

Search Villas in Southern Illinois

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Check prices for these dates

Next weekend
19 Dec - 21 Dec
In two weeks
26 Dec - 28 Dec
In one month
9 Jan - 11 Jan
In two months
6 Feb - 8 Feb

Our top choices for Southern Illinois villas

Exterior
Copperfield of Centralia - Unit 1 - Centralia, IL

Copperfield of Centralia - Unit 1 - Centralia, IL

Copperfield of Centralia - Unit 1 - Centralia, IL
Centralia
10.0 out of 10, Exceptional, (19)
"Great property and location! Rooms were comfortable and the living area and kitchen were great for large groups. "
United States
Q W.
The price is AED 749
AED 1,354 total
includes taxes & fees
11 Jan - 12 January 2026
Copperfield of Centralia - Unit 1 - Centralia, IL
Fridge, microwave, oven, stovetop
3BR Historic St. Charles, MO-Walking distance to Main Street

3BR Historic St. Charles, MO-Walking distance to Main Street

3BR Historic St. Charles, MO-Walking distance to Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (16)
"The location was perfect for a girls night out! Home was very well kept and comfy. "
United States
Rachel L.
The price is AED 724
AED 1,946 total
includes taxes & fees
15 Dec - 16 Dec
3BR Historic St. Charles, MO-Walking distance to Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Illinois Hotel Reviews

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

10/10 Excellent
"Always a nice clean room. "
ryan 1-night trip
Posted 2 days ago
La Quinta Inn & Suites by Wyndham Effingham

Frequently asked questions

How much do villas in Southern Illinois cost?
Villas in Southern Illinois cost between AED 1,354 and AED 1,946 per night. These getaways give you the privacy of your own space at a price that doesn't break the bank. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Why book your villa in Southern Illinois with Expedia?
We think that vacations shouldn't be hard, so if you're searching for villas at an affordable price, Expedia has your back. Save cash and opt for an all-inclusive stay, or splurge on a plush villa to surprise your loved ones. Use our handy search filters to find a place in Southern Illinois that matches your needs.
How can I find cheap villas in Southern Illinois?
With Expedia's handy filter tool, scoring cheap villas in Southern Illinois is a snap. To find accommodations that'll make your wallet happy, narrow your search by star rating, budget and amenities.