A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Resorts & Hotels with Spas in Southern Indiana

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Resorts & Hotels with Spas

Tonight
2 Oct - 3 Oct
Tomorrow
3 Oct - 4 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Southern Indiana hotels with a spa

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.
A modern hotel room with a large window, a sofa, a red armchair, and a small table.
A balcony with a view of a river, a bridge, and a cityscape.

1. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
AED 520
AED 612 total
includes taxes & fees
31 Oct - 1 Nov
Galt House Hotel Trademark Collection by Wyndham
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A modern interior with a fireplace, bookshelves, and seating areas.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

2. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
  • Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
AED 933
AED 1,098 total
includes taxes & fees
30 Oct - 31 Oct
Omni Louisville Hotel
A restaurant with round tables, chairs, chandeliers, and a bar area.
A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.
A large hotel with a prominent 'Caesars' sign, multiple floors, and a symmetrical facade.
A casino with multiple gaming tables and slot machines, a red carpet, and ornate chandeliers.

3. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
Elizabeth
  • Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
AED 222
AED 320 total
includes taxes & fees
1 Nov - 2 Nov
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A modern bathroom with a shower, a sink, and a large mirror.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

4. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
AED 621
AED 749 total
includes taxes & fees
25 Oct - 26 Oct
21c Museum Hotel Louisville
A treatment room with a massage table, a desk with a computer, and a large mirror.
A large, multi-story hotel with a prominent dome and arched windows, featuring a well-lit entrance and landscaped gardens.
A golf course with a flag, a sand bunker, and a building in the background.
A luxurious bathroom with a large mirror, a bathtub, and a shower area.

5. Belterra Casino Resort

Belterra Casino Resort
Florence
  • Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
AED 466
AED 567 total
includes taxes & fees
15 Oct - 16 Oct
Belterra Casino Resort
A hotel lobby with a chandelier, wooden railings, a reception desk, and a large arched doorway.
A spacious indoor area with a staircase, a vending machine, and a business center sign.
A hotel room with a bed, desk, chair, and a green accent wall.
An indoor swimming pool with clear water, surrounded by lounge chairs and a small seating area.

6. Quality Inn Seymour I-65

Quality Inn Seymour I-65
Seymour
  • Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.
AED 297
AED 332 total
includes taxes & fees
1 Nov - 2 Nov
Quality Inn Seymour I-65
A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.
A modern bathroom with a shower, a vanity with a sink, and a toilet. There are wooden shelves and a vase with flowers on the vanity.
A living room with a sofa, coffee table, and a television mounted on the wall.
A porch with white rocking chairs and a table, a window with blinds, and a view of a green landscape.

7. Pillow and Paddock B&B

Pillow and Paddock B&B
La Grange
  • Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
AED 1,241
AED 1,368 total
includes taxes & fees
7 Oct - 8 Oct
Pillow and Paddock B&B
View all properties

Choose what matters most at spa hotels in Southern Indiana

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Southern Indiana Hotel Reviews

Drury Inn & Suites Evansville East

Drury Inn & Suites Evansville East

10/10 Excellent
"The manager was amazing and obviously really cares about his hotel. I saw him helping people find seats for kickback, working the front desk, helping with breakfast, and by the elevators talking with guests. He was pleasant and helpful at all times."
Deirdre 1-night trip
Posted 3 days ago
Drury Inn & Suites Evansville East