Southern Indiana Vacations

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Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
The entrance to the Kentucky Science Center with a large circular structure in the foreground.

West Main Historic District

Boasting the largest collection of cast iron faƧades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southern Indiana Vacation Packages

Southern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
The price is AEDĀ 244 per night from Jul 20 to Jul 21
AEDĀ 244
AEDĀ 276 total
20 Jul - 21 Jul
includes taxes & fees
7/10 Good! (3,235 reviews)
"Great room for a fantastic midweek price with a view over a man-made lake. Convenient location en route to Louisville across the non-toll bridge into downtown. Clean. Up to date. Comfortable. The deposit aspect was done in a way that was a bit confusing. But the stay itself could not have been ..."

Reviewed on 16 July 2026

Radisson Hotel Louisville North
Santas Lodge and Resort

Santas Lodge and Resort

2.5 out of 5
91 W CHRISTMAS BLVD Santa Claus IN
Fully refundableReserve now, pay when you stay
The price is AEDĀ 379 per night from Aug 16 to Aug 17
AEDĀ 379
AEDĀ 425 total
16 Aug - 17 Aug
includes taxes & fees
Santas Lodge and Resort
Derby Hotel & Suites

Derby Hotel & Suites

2 out of 5
505 K Marriot Dr Clarksville IN
Fully refundable
The price is AEDĀ 210 per night from Jul 23 to Jul 24
AEDĀ 210
AEDĀ 238 total
23 Jul - 24 Jul
includes taxes & fees
Derby Hotel & Suites
See all 1,579 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southern Indiana attractions

A water slide with a yellow and green inflatable raft carrying three people.
Photo by Indiana Office of Tourism Development
Open Photo by Indiana Office of Tourism Development

Holiday World and Splashin' Safari

9.4/10 (294 reviews)
Holiday World features themed holiday areas with thrilling coasters and water attractions. Enjoy complimentary soft drinks and sunscreen while experiencing the world's longest water coaster, Wildebeest.
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